Mucosal Interleukin‐10 depletion in steroid‐refractory Crohn's disease patients

Autor: Anna Carrasco, Eva Tristán, Fernando Fernández‐Bañares, Albert Martín‐Cardona, Montserrat Aceituno, Yamile Zabana, Lourdes Fluvià, José María Hernández, Violeta Lorén, Josep Manyé, Antonio Salas, Xavier Andújar, Carme Loras, Maria Esteve

Publikováno v: Immunity, Inflammation and Disease, Vol 10, Iss 10, Pp n/a-n/a (2022)

Abstract Background Previous studies suggested that Interleukin‐10 (IL‐10) depletion in Crohn's disease (CD) could predict outcome. Aim: To determine IL‐10 in blood and at different intestinal locations in patients with active CD and to assess

Externí odkaz: https://doaj.org/article/8e9bc48e94a8473f96d8e1e27cda2a7f

Response Variability to Drug Testing in Two Models of Chemically Induced Colitis

Autor: Roger Suau, Anna Garcia, Carla Bernal, Mariona Llaves, Katharina Schiering, Eva Jou-Ollé, Alex Pertegaz, Arce Garcia-Jaraquemada, Ramon Bartolí, Violeta Lorén, Patri Vergara, Míriam Mañosa, Eugeni Domènech, Josep Manyé

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6424

The lack of knowledge regarding the pathogenesis of IBD is a challenge for the development of more effective and safer therapies. Although in vivo preclinical approaches are critical for drug testing, none of the existing models accurately reproduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a253576731a6c3e9b937f5a4ba75440
https://ddd.uab.cat/record/274413

Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn’s disease

Autor: Antonio Julià, Adrià Aterido, Yamile Zabana, Juan Jose Lozano, Elisabet Pedrosa, Maria Rosa Sarrias, Violeta Lorén, Eduard Cabré, Arce Garcia-Jaraquemada, María Vicario, Míriam Mañosa, J. Manyé, Eugeni Domènech, José Troya, Miriam Ferreiro

Publikováno v: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Crohn's disease (CD) is a complex and multifactorial illness. There are still considerable gaps in our knowledge regarding its pathophysiology. A transcriptomic approach could shed some light on little-known biological alterations of the disease. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f61877c688abff32a4fd7854cf83eb
https://doi.org/10.1152/ajpgi.00027.2020

Comparison of lymphocyte isolation methods for endoscopic biopsy specimens from the colonic mucosa

Autor: Montserrat Forné, Judith Vidal, Rebeca Santaolalla, Fernando Fernández-Bañares, Elisabet Pedrosa, Mercè Rosinach, Xavier Andújar, Maria Esteve, Josep Mañé, Marco Fernández, Josefina Mallolas, Violeta Lorén, Carme Loras, Josep Maria Viver, Anna Carrasco

Publikováno v: Journal of Immunological Methods. 389:29-37

An ideal method of immune cell isolation should provide maximum cell yield without disturbing functional properties. Intestinal endoscopic biopsies, in contrast to surgical samples, allow the study of all disease stages but have the drawback of a min

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba33f4c081d0fbf565f1193ca8a6a28
https://doi.org/10.1016/j.jim.2012.12.006

Bacteria and spontaneous experimental colitis: immunological changes

Autor: Isabel Ojanguren, Violeta Lorén, E. Domènech, Miquel A. Gassull, Elisabet Pedrosa, E. Cabré, Josep Mañé

Publikováno v: European Journal of Clinical Investigation. 41:1047-1053

Eur J Clin Invest 2011; 41 (10): 1047–1053 Abstract Background Intestinal commensal flora seems to be a requisite for both human and experimental intestinal inflammation. Our aim was to assess the immunological changes in the colon of IL-10(−/−

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13d989c8ad8692cee0f2e8701e33d980
https://doi.org/10.1111/j.1365-2362.2011.02499.x