Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Violeta L. Marin"'
Autor:
Andrea G. Shergalis, Violeta L. Marin, David Y. Rhee, Sameera Senaweera, Rebecca L. McCloud, Judith A. Ronau, Charles W. Hutchins, Shaun McLoughlin, Kevin R. Woller, Scott E. Warder, Anil Vasudevan, Justin M. Reitsma
Publikováno v:
ACS Chemical Biology. 18:331-339
Autor:
Anup K. Upadhyay, Ron Pithawalla, Rodger F. Henry, Russell A. Judge, Chaohong Sun, Justin A. Simanis, Leiming Li, Violeta L. Marin, Andrew M. Petros, Pierre M. Bodelle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1708-1713
The tandem TUDOR domains present in the non-catalytic C-terminal half of the KDM4A, 4B and 4C enzymes play important roles in regulating their chromatin localizations and substrate specificities. They achieve this regulatory role by binding to differ
Autor:
Aleksandra Baranczak, Paul L. Richardson, Anil Vasudevan, Jasmina Marjanovic, Henning Stöckmann, Violeta L. Marin
Publikováno v:
MedChemComm. 8:789-795
Determination of target engagement following drug administration under physiological conditions is essential for understanding clinical outcomes of therapeutic candidates. While the list of potential techniques that enable studies of target engagemen
Autor:
Min Cheng, Peter Kovar, Patricia E. Bacon-Trusk, Julie L. Wilsbacher, Paul L. Richardson, Anil Vasudevan, Aleksandra Baranczak, Todd Hopkins, Sandra T. Haman, Stormy L. Koeniger, Violeta L. Marin
Publikováno v:
MedChemComm. 10(6)
Phenotypic screening provides compounds with very limited target cellular localization data. In order to select the most appropriate target identification methods, determining if a compound acts at the cell-surface or intracellularly can be very valu
Autor:
Leyu Wang, Viktor Todorović, Ramkrishna Sadhukhan, C. Gerstein, Anil Vasudevan, Henning Stöckmann, Violeta L. Marin, Victoria E. Scott, Marc R. Lake, Paul L. Richardson
Publikováno v:
Journal of the American Chemical Society. 139(46)
Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry. Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which have low temporal and spatial resolution and entail
Autor:
Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal func
Autor:
András Herner, Qing Lin, Laura Miesbauer, Violeta L. Marin, Melanie J. Patterson, Damien B. Ready, Jasmina Marjanovic, Jon D. Williams, Tracey M. Lewandowski, Anil Vasudevan
Publikováno v:
Journal of the American Chemical Society
Photoaffinity labels are powerful tools for dissecting ligand–protein interactions, and they have a broad utility in medicinal chemistry and drug discovery. Traditional photoaffinity labels work through nonspecific C–H/X–H bond insertion reacti
Autor:
Paul L. Richardson, Henning Stöckmann, Donald J. Davidson, Paul Nimmer, Anil Vasudevan, Violeta L. Marin, Corina Balut
Publikováno v:
Chembiochem : a European journal of chemical biology. 17(2)
Membrane-bound proteins are important pharmaceutical drug targets, yet few strategies exist for the identification of small-molecule-targeted membrane proteins in live-cell systems. By exploiting metabolic glycan engineering of cell membrane proteins
Autor:
Shannon Duggan, Hua Tang, Paul L. Richardson, Shaun M. McLoughlin, Scott E. Warder, Violeta L. Marin
Publikováno v:
Journal of biomolecular screening. 21(2)
The pharmaceutical industry has been continually challenged by dwindling target diversity. To obviate this trend, phenotypic screens have been adopted, complementing target-centric screening approaches. Phenotypic screens identify drug leads using cl
Autor:
Violeta L. Marin, Bruce A. Armitage, David G. Whitten, Kirsten Bradford, Chris Suhrada, Duncan Mcbranch, Stuart A. Kushon
Publikováno v:
Langmuir. 19:6456-6464
An improved assay for the detection of a 20-mer DNA sequence coding for the Anthrax Lethal Factor sequence that utilizes fluorescence superquenching and peptide nucleic acids (PNAs) is reported. The basis for this assay is a microsphere sensor that i