The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling.

Autor: Smail Messaoudi, An Di Zhang, Violaine Griol-Charhbili, Brigitte Escoubet, Junichi Sadoshima, Nicolette Farman, Frederic Jaisser

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30156 (2012)

Experimental and clinical studies have shown that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system; however, the signalling pathways involved in the pathophysiological effects of aldosterone/

Externí odkaz: https://doaj.org/article/b89b461687e94da88897642bde4e2bc2

Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia

Autor: Patrick Bruneval, Chantal Mandet, Nadine Bouby, John H. Krege, Violaine Griol-Charhbili, Erij Messadi, Oliver Smithies, Marie Pascale Vincent, Juliana Almada Colucci, Christine Richer, François Alhenc-Gelas

Publikováno v: The FASEB Journal. 24:4691-4700

Angiotensin I-converting enzyme (ACE; kininase II) levels in humans are genetically determined. ACE levels have been linked to risk of myocardial infarction, but the association has been inconsistent, and the causality underlying it remains undocumen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498f772bc40b27c35406a0db0a09e529
https://doi.org/10.1096/fj.10-165902

Tissue Kallikrein Is Involved in the Cardioprotective Effect of AT1-Receptor Blockade in Acute Myocardial Ischemia

Autor: François Alhenc-Gelas, Christine Richer, Pierre Meneton, Violaine Griol-Charhbili, E Messadi-Laribi, Anne Pizard, Didier Heudes, Marie-Pascale Vincent

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 323:210-216

Angiotensin-converting enzyme inhibitors limit infarct size in animal models of myocardial ischemia reperfusion injury. This effect has been shown to be due to inhibition of bradykinin degradation rather than inhibition of angiotensin II formation. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64c8c8bf40f0dd27075e49e24c6a7ae
https://doi.org/10.1124/jpet.107.124859

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure

Autor: Laura E. Benjamin, Daniel Henrion, Carlos Labat, Aurelie Nguyen Dinh Cat, Frederic Jaisser, Laurent Loufrani, Patrick Lacolley, Violaine Griol-Charhbili, Nicolette Farman

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2010, 24 (7), pp.2454-2463. ⟨10.1096/fj.09-147926⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2010, 24 (7), pp.2454-63. ⟨10.1096/fj.09-147926⟩

International audience; Pathophysiological aldosterone (aldo)/mineralocorticoid receptor (MR) signaling has significant effects on the cardiovascular system, resulting in hypertension and cardiovascular remodeling; however, the specific contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424e61bcbc282bc1923bf678d1d41552
https://hal.archives-ouvertes.fr/hal-02510516

Tissue kallikrein deficiency and renovascular hypertension in the mouse

Autor: Jean-Luc Elghozi, Marie-Pascale Vincent, François Alhenc-Gelas, Laurent Sabbah, Nicholas Picard, Patrick Bruneval, Véronique Baudrie, Pierre Meneton, Dominique Laude, Violaine Griol-Charhbili, Christine Richer, Juliana Almada Colucci

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 296(5)

The kallikrein kinin system (KKS) is involved in arterial and renal functions. It may have an antihypertensive effect in both essential and secondary forms of hypertension. The role of the KKS in the development of two-kidneys, one-clip (2K1C) hypert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71f519b656e92d84d0039654dd8c113
https://pubmed.ncbi.nlm.nih.gov/19244588