Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Viola Trentinaglia"'
Autor:
Daniel Vitt, Kristina Wolf, Roland Baumgartner, Nobumitsu Tajima, Tokuyuki Yamashita, Viola Trentinaglia, Marcus Blisse, Andrea Aschenbrenner, Tanja Wieber, Martin Lang, Markus H.J. Seifert, Hitoshi Noda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5417-5422
We report on a hit generation and hit-to-lead program of a novel class of glucokinase activators (GKAs). Hit compounds, activators at low glucose concentration only were identified by vHTS. Scaffold modification reliably afforded activators also at h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246fbaca25d058c145ef45696be1693c
https://doi.org/10.1016/j.bmcl.2011.06.128
https://doi.org/10.1016/j.bmcl.2011.06.128
Autor:
Kristina Wolf, Jan Mies, Johann Leban, Markus H.J. Seifert, Sandra Rath, Viola Trentinaglia, Marcel Baierl, Astrid Gotschlich, Kerstin Kronthaler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5858-5862
A novel class of NF-kappaB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-kappaB signaling in a whole cell reporter gene assay in the micro-molar rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b793f9a96141d771760a6445545b9e
https://doi.org/10.1016/j.bmcl.2007.08.022
https://doi.org/10.1016/j.bmcl.2007.08.022
Autor:
Stefan Hecht, Klaus Kis, Felix Rohdich, Viola Trentinaglia, Sabine Amslinger, Petra Adam, Johann Jauch, Adelbert Bacher, Wolfgang Eisenreich
Publikováno v:
Tetrahedron Letters. 43:8929-8933
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0ddbfd1b3091c352376905909ad23d
https://doi.org/10.1016/s0040-4039(02)02195-0
https://doi.org/10.1016/s0040-4039(02)02195-0