Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Viola Seitz"'
Autor:
Melih Özgür Celik, Viola Seitz, Fatih Yergöz, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typical
Externí odkaz:
https://doaj.org/article/d24edb3270114fefa997af4d5bc07964
Autor:
Antonio Pellegrino, Sandra Mükusch, Viola Seitz, Christoph Stein, Friedrich W. Herberg, Harald Seitz
Publikováno v:
Medical Sciences, Vol 10, Iss 4, p 63 (2022)
The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli. The Ankyrin-rich mem
Externí odkaz:
https://doaj.org/article/d1350019d9ae443eb9975b4fd90a1a70
Autor:
Melih Celik, Viola Seitz, Fatih Yergoz, Sandeep Dembla, Nina Blum, Stefan Schulz, Christoph Stein
Background and Purpose NFEPP is a newly-designed pain killer selectively activating G-protein coupled mu opioid receptors in injured tissues, and therefore devoid of central side effects. However, the cellular mechanisms underlying NFEPP’s antinoci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7cec252eb2e21e488cc28c701d333c
https://doi.org/10.22541/au.165702074.41843063/v1
https://doi.org/10.22541/au.165702074.41843063/v1
Publikováno v:
J Neurosci
Interleukin-4 (IL-4) is an anti-inflammatory cytokine, which can be protective in inflammatory and neurologic disorders, and can alleviate pain. Classically, IL-4 diminishes pain by blocking the production of proinflammatory cytokines. Here, we uncov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5b33278107307fd5957945ec55c7f5
https://pubmed.ncbi.nlm.nih.gov/33593854
https://pubmed.ncbi.nlm.nih.gov/33593854
Autor:
Halina Machelska, Ana Lastra, Sara González-Rodríguez, Luis Menéndez, Ana Baamonde, Christoph Stein, Viola Seitz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f8fa099a4b66b0f8d951ccd99b776d
https://doi.org/10.1038/s41598-020-75509-4
https://doi.org/10.1038/s41598-020-75509-4
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608838
Patch clamp is an electrophysiological technique that allows to analyze the activity of ion channels in neurons. In this chapter, we provide a detailed description of patch clamp protocol to measure the effect of a μ-opioid receptor agonist on the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c274e6ea3ed631178f2c5e5e5ca0a2e5
https://doi.org/10.1007/978-1-0716-0884-5_12
https://doi.org/10.1007/978-1-0716-0884-5_12
Autor:
Marcus Weber, Dominika Labuz, Michael Kloner, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Roger Negrete, Viola Seitz, Halina Machelska, Julia Temp
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17aa5edf8436bfdf00a0f12c0c143b1c
https://doi.org/10.1038/s41598-019-55886-1
https://doi.org/10.1038/s41598-019-55886-1
Autor:
Halina Machelska, Viola Seitz, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Marcus Weber, Michael Kloner, Roger Negrete, Dominika Labuz, Julia Temp
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a9ceb3cec5fd05b709fbc6f747bb4e
http://link.springer.com/article/10.1038/s41598-020-61224-7
http://link.springer.com/article/10.1038/s41598-020-61224-7
Publikováno v:
British Journal of Pharmacology
Background and Purpose: Adverse side effects of conventional opioids can be avoided if ligands selectively activate peripheral opioid receptors in injured tissue. Injury and inflammation are typically accompanied by acidification. In this study, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba99b6f33fdab75bfce787d1328822c