Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Viola Ruddat"'
Autor:
Lise Lamoureux, Sharon L R Simon, Margot Plews, Viola Ruddat, Simone Brunet, Catherine Graham, Stefanie Czub, J David Knox
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64044 (2013)
The difficulty in developing a diagnostic assay for Creutzfeldt - Jakob disease (CJD) and other transmissible spongiform encephalopathies (TSEs) stems in part from the fact that the infectious agent is an aberrantly folded form of an endogenous cellu
Externí odkaz:
https://doaj.org/article/cf2172f98b0b417dbf9e4fc873b06156
Autor:
Wladek Minor, Jing Zhou, Aaron T. Wecksler, Michael L. Neidig, Edward I. Solomon, Theodore R. Holman, Maksymilian Chruszcz, Erika N. Segraves, Viola Ruddat
Publikováno v:
Biochemistry. 45:10233-10242
In wild-type soybean LO-1 (WT sLO-1), Asn694 is a weak sixth ligand that is thought to becritical for enzymatic catalysis. In this investigation, N694G sLO-1 was studied to probe its contributionat this sixth ligand position to the kinetic and spectr
Publikováno v:
The Prostate. 64:128-138
BACKGROUND. Prostate cancer (PCa) is the leading cancer related death in America. Gleasongradingiscurrentlythepredominantmethodforprediction,withonlyfewbiomarkers available. More biomarkers, especially as they relate to cancer progression are desirab
Autor:
Theodore R Holman, Ilya Chorny, Stephanie Whitman, Victor Kenyon, Noah Perrin, Matthew P. Jacobson, Claude F. Bernasconi, Rakesh Mogul, Viola Ruddat, Cameron Chen
Publikováno v:
Biochemistry. 43:13063-13071
There is much debate whether the fatty acid substrate of lipoxygenase binds "carboxylate-end first" or "methyl-end first" in the active site of soybean lipoxygenase-1 (sLO-1). To address this issue, we investigated the sLO-1 mutants Trp500Leu, Trp500
Publikováno v:
The Journal of Organic Chemistry. 69:5232-5239
The deprotonation of pentacarbonyl[(3-diethylamino-2,4-dimethyl)cyclobut-2-ene-1-ylidene]chromium (1d) and pentacarbonyl[(3-diethylamino-4-methyl-2-phenyl)cyclobut-2-ene-1-ylidene]chromium (1e) leads to antiaromatic conjugate anions by virtue of thei
Publikováno v:
Biochemistry. 42:4172-4178
Herein, we report on the role of the allosteric site in the activation mechanism of soybean lipoxygenase-1 utilizing stopped-flow inhibition kinetic studies. The K(D) for the activation was determined to be 25.9 +/- 2.3 microM and the rate constant f
Autor:
Stefanie Czub, Margot Plews, Lise Lamoureux, Simone Brunet, Sharon L.R. Simon, J. David Knox, Viola Ruddat, Catherine Graham
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64044 (2013)
PLoS ONE
PLoS ONE
The difficulty in developing a diagnostic assay for Creutzfeldt - Jakob disease (CJD) and other transmissible spongiform encephalopathies (TSEs) stems in part from the fact that the infectious agent is an aberrantly folded form of an endogenous cellu
Autor:
Viola Ruddat, Claude F. Bernasconi
Publikováno v:
Journal of the American Chemical Society. 124(50)
A kinetic study of the reversible deprotonation of substituted (methylthiophenylcarbene)pentacarbonyltungsten(0) ((CO)(5)W=C(SC(6)H(4)Z)CH(3)) and of substituted (benzoxymethylcarbene)pentacarbonyltungsten(0) ((CO)(5)W=C(OCH(2)C(6)H(4)Z)CH(3)) by pri
Autor:
Margot Plews, Catherine Graham, J. David Knox, Sharon L.R. Simon, Stefanie Czub, Lise Lamoureux, Viola Ruddat
Publikováno v:
Proteome Science
Proteome Science, Vol 9, Iss 1, p 6 (2011)
Proteome Science, Vol 9, Iss 1, p 6 (2011)
Background Transmissible spongiform encephalopathy diseases are untreatable, uniformly fatal degenerative syndromes of the central nervous system that can be transmitted both within as well as between species. The bovine spongiform encephalopathy (BS