Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Viola Previtali"'
Autor:
Beatrice Balboni, Francesco Rinaldi, Viola Previtali, Andrea Ciamarone, Stefania Girotto, Andrea Cavalli
Publikováno v:
Cancers, Vol 15, Iss 6, p 1817 (2023)
In recent years, the RAD52 protein has been highlighted as a mediator of many DNA repair mechanisms. While RAD52 was initially considered to be a non-essential auxiliary factor, its inhibition has more recently been demonstrated to be synthetically l
Externí odkaz:
https://doaj.org/article/87d642d97e9e4b0c8dbe64f3ff2f6ede
Autor:
Viola Previtali, Ulrik Bering Keiding, Asger Hegelund Olsen, Jorge Peiró Cadahía, Anne Skovsbo Clausen, Andreas Kjaer, Thomas Lars Andresen, Anders Elias Hansen, Mads Hartvig Clausen
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100019- (2022)
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from i
Externí odkaz:
https://doaj.org/article/287cda2a79ce492082e2d346cf4a50cb
Autor:
Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen
Publikováno v:
Molecules, Vol 27, Iss 2, p 521 (2022)
Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus,
Externí odkaz:
https://doaj.org/article/9ff3f2753c5f422ebf7d0272b8ae2f5e
Autor:
Viola Previtali, Helene B. Mihigo, Rebecca Amet, Anthony M. McElligott, Daniela M. Zisterer, Isabel Rozas
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 485 (2020)
We previously identified a guanidinium-based lead compound that inhibited BRAF through a hypothetic type-III allosteric mechanism. Considering the pharmacophore identified in this lead compound (i.e., “lipophilic group”, “di-substituted guanidi
Externí odkaz:
https://doaj.org/article/901b9fe61d644a439840a7484ae0cc01
Autor:
Mohamed, Shaaban, Ahmed S, Abdel-Razek, Viola, Previtali, Mads Hartvig, Clausen, Charlotte H, Gotfredsen, Hartmut, Laatsch, Ling, Ding
Publikováno v:
Natural product research.
The fungal endophyte
Autor:
Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy, Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Anthony M. McElligott, Daniela M. Zisterer
Publikováno v:
Life sciences. 290
We have recently described a novel guanidinium-based compound, VP79s, which induces cytotoxicity in various cancer cell lines. Here, we aim to investigate the activity of VP79s and associated mechanisms of action in multiple myeloma (MM) cells in vit
Autor:
Mads Hartvig Clausen, Asger Hegelund Olsen, Ulrik Bering Keiding, Andreas Kjaer, Jorge Peiró Cadahía, Anders Elias Hansen, Viola Previtali, Anne Skovsbo Clausen, Thomas Lars Andresen
Publikováno v:
Previtali, V, Keiding, U B, Olsen, A H, Peiró Cadahía, J, Clausen, A S, Kjaer, A, Andresen, T L, Hansen, A E & Clausen, M H 2022, ' Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs ', European Journal of Medicinal Chemistry Reports, vol. 4, 100019 . https://doi.org/10.1016/j.ejmcr.2021.100019
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from i
Autor:
Mohamed Shaaban, Ahmed S. Abdel-Razek, Viola Previtali, Mads Hartvig Clausen, Charlotte H. Gotfredsen, Hartmut Laatsch, Ling Ding
The fungal endophyte Aspergillus sp. strain FVL2, isolated from the traditional medicinal fennel plant, Foeniculum vulgare, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation delivered three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a2fd4857cc406c973ab59b6d823389
Autor:
Isabel Rozas, Daniela M. Zisterer, Anthony M. McElligott, Helene B. Mihigo, Viola Previtali, Rebecca Amet
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 13, Iss 485, p 485 (2020)
Volume 13
Issue 12
Pharmaceuticals, Vol 13, Iss 485, p 485 (2020)
Volume 13
Issue 12
We previously identified a guanidinium-based lead compound that inhibited BRAF through a hypothetic type-III allosteric mechanism. Considering the pharmacophore identified in this lead compound (i.e., &ldquo
lipophilic group&rdquo
&ldquo
lipophilic group&rdquo
&ldquo
Autor:
Nikolaj Sten Troelsen, Katarina Petrovic, Mads Hartvig Clausen, Jorge Peiró Cadahía, Viola Previtali
Publikováno v:
Previtali, V, Petrovic, K, Peiro Cadahía, J, Troelsen, N S & Clausen, M H 2020, ' Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis ', Bioorganic & Medicinal Chemistry, vol. 28, no. 2, 115247 . https://doi.org/10.1016/j.bmc.2019.115247
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes severe joints damage and other extra-articular alterations. Despite the efficacy of low-dose methotrexate (LD-MTX) in RA treatment, adverse effects are the predominant reasons fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea98a1a47932017a4e0443dab3c071a
https://orbit.dtu.dk/en/publications/cd3d973c-2256-473f-bd20-589287736b18
https://orbit.dtu.dk/en/publications/cd3d973c-2256-473f-bd20-589287736b18