Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Viola Introini"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/c3108bc1c62c4be687a85e52facb9e80
Autor:
Prasun Kundu, Deboki Naskar, Shannon J. McKie, Sheena Dass, Usheer Kanjee, Viola Introini, Marcelo U. Ferreira, Pietro Cicuta, Manoj Duraisingh, Janet E. Deane, Julian C. Rayner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family found in all Plasmodium species, but are significantly expanded in P. vivax and closely related parasites. We show that multiple P. vivax TRAgs are expressed on the merozoit
Externí odkaz:
https://doaj.org/article/1d5db4ca321d48589e92ba6963931162
Autor:
Viola Introini, Gururaj Rao Kidiyoor, Giancarlo Porcella, Pietro Cicuta, Marco Cosentino Lagomarsino
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract The nucleus plays a central role in several key cellular processes, including chromosome organisation, DNA replication and gene transcription. Recent work suggests an association between nuclear mechanics and cell-cycle progression, but many
Externí odkaz:
https://doaj.org/article/9d09cc520b4449ccbf38b9c49187eba3
Autor:
Viola Introini, Alejandro Marin-Menendez, Guilherme Nettesheim, Yen-Chun Lin, Silvia N. Kariuki, Adrian L. Smith, Letitia Jean, John N. Brewin, David C. Rees, Pietro Cicuta, Julian C. Rayner, Bridget S. Penman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be
Externí odkaz:
https://doaj.org/article/e6afa95052a148bb94000f442cc19fc0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Forces and mechanical properties of cells and tissues set constraints on biological functions, and are key determinants of human physiology. Changes in cell mechanics may arise from disease, or directly contribute to pathogenesis. Malaria gives many
Externí odkaz:
https://doaj.org/article/b8c324a1d57945af87b137e665c56645
Autor:
Janna Ehlert, Arne Alder, Viola Introini, Julia Weder, Pietro Cicuta, Tim W. Gilberger, Matthias Preller
Publikováno v:
Proceedings, Vol 22, Iss 1, p 9 (2019)
Malaria remains a devastating disease with nearly half a million deaths per year. The WHO reports a stagnating number of new infections every year without a significant decline, as a result of insufficient access to antimalarials in endemic regions a
Externí odkaz:
https://doaj.org/article/ed33126c845d49a7a3316f80cb189213
Autor:
Prasun Kundu, Deboki Naskar, Shannon McKie, Sheena Dass, Usheer Kanjee, Viola Introini, Marcelo U. Ferreira, Manoj Duraisingh, Janet Deane, Julian C. Rayner
Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family in all Plasmodium species, significantly expanded in P. vivax, but their function is not currently known. We show that multiple P. vivax TRAgs are expressed on the merozoite surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c1261ab3b406ca10a89863c89f815b
https://doi.org/10.1101/2022.09.30.510049
https://doi.org/10.1101/2022.09.30.510049
Autor:
Hugo Belda, Moritz Treeck, Benoit Gamain, Viola Introini, Claudine Bisson, Malgorzata Broncel, Heledd Davies, Marta Tibúrcio, Dominique Dorin-Semblat, Jean-Philippe Semblat, Xingda Ye, Myrsini Kaforou
Publikováno v:
Nature microbiology
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2020, 5 (6), pp.848-863. ⟨10.1038/s41564-020-0702-4⟩
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2020, 5 (6), pp.848-863. ⟨10.1038/s41564-020-0702-4⟩
Summary The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is closely linked to the increase in rigidity of infected erythrocytes and their adhesion to endothelial receptors, obstructing blood flow to vital organs
Autor:
Dominic P. Kwiatkowski, Yen-Chun Lin, Thomas N. Williams, Johnstone Makale, Alex Macharia, Julian C. Rayner, Benjamin J. Ravenhill, Wilfred Nyamu, Manuela Carrasquilla, Michael P. Weekes, Pietro Cicuta, Kirk A. Rockett, Alejandro Marin-Menendez, Jurij Kotar, Viola Introini, Metrine Tendwa, J. Alexandra Rowe, Silvia N. Kariuki
Publikováno v:
Kariuki, S, Marin-Menendez, A, Introini, V, Ravenhill, B J, Lin, Y C, Macharia, A, Makale, J, Tendwa, M, Nyamu, W, Kotar, J, Carrasquilla, M, Rowe, A J, Rockett, K A, Kwiatkowski, D P, Weekes, M P, Cicuta, P, Williams, T N & Rayner, J C 2020, ' Red blood cell tension protects against severe malaria in the Dantu blood group ', Nature, vol. 585, no. 7826, pp. 579-583 . https://doi.org/10.1038/s41586-020-2726-6
Nature
Nature
Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19654963f2d00c404ce3c5e3ff314214
Autor:
Matthias Preller, Julia Weder, Pietro Cicuta, Tim W. Gilberger, Viola Introini, Janna Ehlert, Arne Alder
Publikováno v:
Proceedings, Vol 22, Iss 1, p 9 (2019)
Malaria remains a devastating disease with nearly half a million deaths per year. The WHO reports a stagnating number of new infections every year without a significant decline, as a result of insufficient access to antimalarials in endemic regions a