Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Autor: Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored

Externí odkaz: https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9

Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics

Autor: Viola D’Ambrosio, Pietro Manuel Ferraro, Gianmarco Lombardi, Simonetta Friso, Giovanni Gambaro

Publikováno v: Nutrients, Vol 14, Iss 23, p 4961 (2022)

Nephrolithiasis is an increasingly prevalent condition, especially in high income countries, and is associated with high morbidity. Extraordinary progress in genetics made the identification of genetic forms of nephrolithiasis possible. These genetic

Externí odkaz: https://doaj.org/article/bb2101f617d84d4d896b0f743906c3f9

Lumasiran in the Management of Patients with Primary Hyperoxaluria Type 1: From Bench to Bedside

Autor: Viola, D'Ambrosio, Pietro Manuel, Ferraro

Publikováno v: International Journal of Nephrology and Renovascular Disease. 15:197-206

Primary hyperoxaluria (PH) is a rare genetic disease caused by excessive hepatic production and elevated urinary excretion of oxalate that leads to recurrent nephrolithiasis, nephrocalcinosis and, eventually, kidney failure. As glomerular filtration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce700fdb9652196001825f3c7e27ddc4
https://doi.org/10.2147/ijnrd.s293682

Trajectories of Kidney Function in Patients with ATTRv Treated with Gene Silencers

Autor: Marco Luigetti, Valeria Guglielmino, Angela Romano, Maria Ausilia Sciarrone, Francesca Vitali, Viola D’Ambrosio, Pietro Manuel Ferraro

Publikováno v: Genes. 13(12)

Hereditary transthyretin amyloidosis (ATTRv; v for “variant”) is the most common form of hereditary amyloidosis, with an autosomal dominant inheritance and a variable penetrance. This disease has a significant variability in clinical presentation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63d7dd50d08335decaac530a684a08d
https://pubmed.ncbi.nlm.nih.gov/36553503

Hyperoxaluric acute kidney injury and frontotemporal dementia

Autor: Viola D'Ambrosio, Elizabeth R Wan, Gerlineke Hawkins-van der Cingel, Keith Siew, Mark Hawthorne, Colley Crawford, Stephen B Walsh

Publikováno v: The Lancet. 401:1530

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04bfef7478ac741e0c2722d6beb84329
https://doi.org/10.1016/s0140-6736(22)02601-0