Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Viola Bordunov"'
Autor:
Ramesha Chakk S, Jin-Hai Wang, Russell Stephen Stabler, Paul Weller, Bong F. Sanpablo, Armando G. Villaseñor, Campbell Jeffrey Allen, Tara Mirzadegan, Viola Bordunov, Chris Allen Broka, Patricia Takahara, James M. Kress, Michelle F. Browner, Keith A. M. Walker, Mary Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4741-4745
The introduction of 3-arylmethyl, 3-aryloxy and 3-arylthio moieties into a 6-methylsulfonylindole framework using rational drug design led to potent, selective COX-2 inhibitors having efficacy in a rat carrageenan air pouch model. Incorporation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b4b4fb3a2267e70d53ca55e5ce32ea
https://doi.org/10.1016/j.bmcl.2004.06.075
https://doi.org/10.1016/j.bmcl.2004.06.075
Autor:
Gill Adrian Liam, Csaba Lehel, Mcintosh Joel, Francisco Xavier Talamas, Roland J. Billedeau, Holger Wesche, David Clark, Eric Brian Sjogren, Matt Wright, Nigel Walker, Stacie A. Dalrymple, Sharada Shenvi Labadie, Camran Parast, Timothy D. Cushing, George Tonn, Michelle F. Browner, Keith A. M. Walker, Viola Bordunov, Pu-Ping Lu, Marie-Louise Smith, Chris Whitehead, Xiao He, Mario G. Cardozo, Juan C. Jaen, Chris Allen Broka, Peng Cheng, Youngsook Shin, Karen Berry, Vijay Baichwal, Shichang Miao, Ronald Charles Hawley, Xiaolin Hao, Michael DeGraffenreid, Marc Labelle
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our early efforts at optimization of the quinoline core, the imidazole and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc82bc82b7e7cf09330f7c5b4a3deba2
https://pubmed.ncbi.nlm.nih.gov/21074993
https://pubmed.ncbi.nlm.nih.gov/21074993
Autor:
Karen Berry, Viola Bordunov, Shichang Miao, David Clark, George Tonn, Timothy D. Cushing, Ronald Charles Hawley, Gill Adrian Liam, Marc Labelle, Csaba Lehel, Pu-Ping Lu, Francisco Xavier Talamas, Vijay Baichwal, Roland J. Billedeau, Mario G. Cardozo, Mcintosh Joel, Peng Cheng, Marie-Louise Smith, Michael DeGraffenreid, Chris Whitehead, Stacie A. Dalrymple, Xiao He, Nigel Walker, Camran Parast, Xiaolin Hao, Holger Wesche, Matt Wright, Eric Brian Sjogren, Keith A. M. Walker, Juan C. Jaen, Chris Allen Broka, Sharada Shenvi Labadie, Michelle F. Browner, Youngsook Shin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our efforts at further optimization of this series, culminating in 2 with su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf43c755172d814362bce5fc139f29d9
https://pubmed.ncbi.nlm.nih.gov/21074992
https://pubmed.ncbi.nlm.nih.gov/21074992
Autor:
J. W. Dankwardt, Robert Than Hendricks, Keith A. M. Walker, Chris Allen Broka, James M. Kress, Jin-Hai Wang, Viola Bordunov, Campbell Jeffrey Allen
Publikováno v:
ChemInform. 35
The 3-arylmethylation of indoles using TMSOTf/Et 3 SiH with a wide variety of substituted benzaldehydes has been accomplished. Under these mild Lewis acid mediated reductive conditions, it was demonstrated that indoles bearing both 6-MeSO 2 and 2-met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be011f9c8d0873f0a1afd80401d8641b
https://doi.org/10.1002/chin.200434125
https://doi.org/10.1002/chin.200434125
Autor:
Campbell Jeffrey Allen, Robert Than Hendricks, Chris Allen Broka, J. W. Dankwardt, Jin-Hai Wang, Keith A. M. Walker, James M. Kress, Viola Bordunov
Publikováno v:
Tetrahedron Letters. 45:4587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adeb71350a87612d0ba5759ffc1d92a8
https://doi.org/10.1016/j.tetlet.2004.04.060
https://doi.org/10.1016/j.tetlet.2004.04.060