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THE GUT MICROBIOME REGULATES EFFICACY OF SULFASALAZINE THERAPY FOR SPONDYLOARTHRITIS IN INFLAMMATORY BOWEL DISEASE

Autor: Svetlana Lima, Amanda Rupert, Wenbing Jin, Monica Viladomiu, Silvia Pires, Viola Woo, Gregory Putzel, Andrew Marderstein, Gabriela Funez-dePagnier1, Wei Yang, Chun-Jun Guo, Ellen Scherl, Randy Longman

Publikováno v: Gastroenterology. 164:S93

Joint inflammation, or spondyloarthritis (SpA), is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD), but the specific role for therapies targeting SpA is not well defined. One of the earliest medications used for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c1168149c223feee53f459fe981a3c
https://doi.org/10.1053/j.gastro.2023.03.172

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Astrocytic junctional adhesion molecule-A regulates T-cell entry past the glia limitans to promote central nervous system autoimmune attack

Autor: Mario Amatruda, Candice Chapouly, Viola Woo, Farinaz Safavi, Joy Zhang, David Dai, Anthony Therattil, Chang Moon, Jorge Villavicencio, Alexandra Gordon, Charles Parkos, Sam Horng

Publikováno v: Brain Communications
Brain Communications, 2022, 4 (2), pp.fcac044. ⟨10.1093/braincomms/fcac044⟩

Contact-mediated interactions between the astrocytic endfeet and infiltrating immune cells within the perivascular space are underexplored, yet represent potential regulatory check-points against CNS autoimmune disease and disability. Reactive astroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab2233351e9c1f107da77421ce313fb
https://www.hal.inserm.fr/inserm-03627220/file/fcac044.pdf

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DEFINING THE ROLE FOR THE GUT MICROBIOME IN THE CLINICAL EFFICACY OF SULFASALAZINE THERAPY FOR IBD ASSOCIATED SPONDYLOARTHRITIS

Autor: Svetlana Ferreira Lima, Amanda Rupert, Monica Viladomiu, Andrew Marderstein, Silvia Pires, Gregory Putzel, Viola Woo, Gabriela Funez-dePagnier, Wen-Bing Jin, Chun-Jun Guo, Ellen Scherl, Randy S. Longman

Publikováno v: The Journal of Immunology. 208:174.01-174.01

Joint inflammation (spondyloarthritis, SpA), is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD), but the specific role for therapies targeting SpA is not well defined. Sulfasalazine (SAS) is a prodrug composed of tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4240517319b80ac603d46fd447c56604
https://doi.org/10.4049/jimmunol.208.supp.174.01

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Transferable Immune Reactive Microbiota Determine Clinical and Immunologic Outcome of FMT in UC

Autor: Svetlana Ferreira Lima, Lasha Gogokhia, Monica Viladomiu, Viola Woo, Andrew Marderstein, Gregory Putzel, Ellen J Scherl, Su-Ellen Brown, John Hambor, Melissa Rosenthal, Vinita Jacob, Carl Crawford, Lance Chou, Randy Longman

Publikováno v: The Journal of Immunology. 204:237.14-237.14

Background Over two million people worldwide suffer from ulcerative colitis (UC). Biologic therapy has significantly improved treatment, but nearly two-thirds of patients attenuate response. Fecal microbiota transplant (FMT) is an emerging therapy fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4fb6845c58c0a0054831f4a55132a62
https://doi.org/10.4049/jimmunol.204.supp.237.14

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Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis

Autor: Svetlana Ferreira Lima, Randy Longman, Amanda Rupert, Monica Viladomiu, Andrew Marderstein, Gregory Putzel, Gabriela Funez-dePagnier, Viola Woo, Maeva L Metz, Ellen J Scherl, Lance Chou

Publikováno v: The Journal of Immunology. 204:237.8-237.8

Spondyloarthritis (SpA) is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Sulfasalazine (SAS) is one of the earliest medications used in IBD and its efficacy in spondyloarthritis is thought to depend on its antiba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de59be40c3c325fd171df4a02424e0b
https://doi.org/10.4049/jimmunol.204.supp.237.8

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IgA-coated

Publikováno v: Science translational medicine. 9(376)

Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis, or synovitis of nonaxial joints. However, a mechanistic unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff169ed0a7786af5e56a6549f6acab5f
https://pubmed.ncbi.nlm.nih.gov/28228648

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Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

Autor: Stephan R. Targan, Alexendar R. Perez, Gretchen E. Diehl, David Q. Shih, Jorge Gandara, Gregory G. Putzel, Ellen Scherl, Svetlana Lima, David R. Withers, Monica Viladomiu, Viola Woo, Andrew R. Marderstein, Jim G. Castellanos, Randy S. Longman

Publikováno v: Immunity. 49:1077-1089.e5

Summary Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c3d05797b6d4a0bac15cd0b56015b1
https://doi.org/10.1016/j.immuni.2018.10.014

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