Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Vinzenz M. Unger"'
Autor:
Lelita T. Braiterman, Nesrin M. Hasan, Samuel Jayakanthan, Svetlana Lutsenko, Vinzenz M. Unger
Publikováno v:
Journal of Biological Chemistry. 292:18760-18774
ATP7B is a copper-transporting P1B-type ATPase (Cu-ATPase) with an essential role in human physiology. Mutations in ATP7B cause the potentially fatal Wilson disease, and changes in ATP7B expression are observed in several cancers. Despite its physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b065828af6abe0a8622e44baf4b6071c
https://doi.org/10.1074/jbc.m117.807263
https://doi.org/10.1074/jbc.m117.807263
Publikováno v:
Journal of Molecular Biology. 427:3921-3934
Members of the receptor tyrosine kinases (RTKs) regulate important cellular functions such as cell growth and migration, which are key steps in angiogenesis, in organ morphogenesis and in the unregulated states, cancer formation. One long-standing pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc33f4426f4264916d1c0f3f08d561
https://doi.org/10.1016/j.jmb.2015.10.003
https://doi.org/10.1016/j.jmb.2015.10.003
Atox1 Contains Positive Residues that Mediate Membrane Association and Aid Subsequent Copper Loading
Autor:
Vinzenz M. Unger, Adrian G. Flores
Publikováno v:
The Journal of Membrane Biology. 246:903-913
Copper chaperones bind intracellular copper and ensure proper trafficking to downstream targets via protein-protein interactions. In contrast to the mechanisms of copper binding and transfer to downstream targets, the mechanisms of initial copper loa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ee2086bfe4415be9aaf6f694a67d9a
https://doi.org/10.1007/s00232-013-9592-1
https://doi.org/10.1007/s00232-013-9592-1
Autor:
Thomas C. Marlovits, Gregory A. Voth, Carsten Mim, Vinzenz M. Unger, Mijo Simunovic, Guenter P. Resch
Publikováno v:
Biophysical Journal. 105:711-719
Key cellular processes are frequently accompanied by protein-facilitated shape changes in the plasma membrane. N-BAR-domain protein modules generate curvature by means of complex interactions with the membrane surface. The way they assemble and the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b02ec3770abb1357403a96264f2106b
https://doi.org/10.1016/j.bpj.2013.06.039
https://doi.org/10.1016/j.bpj.2013.06.039
Autor:
Oliver Daumke, Vinzenz M. Unger
Publikováno v:
Journal of structural biology. 196(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702c908beaaa9d7fb26a141d80ce177
https://pubmed.ncbi.nlm.nih.gov/27651183
https://pubmed.ncbi.nlm.nih.gov/27651183
Autor:
Christopher R. Pope, Vinzenz M. Unger
Publikováno v:
Current Opinion in Structural Biology. 22:514-519
Since its debut in the mid 1970s, electron crystallography has been a valuable alternative in the structure determination of biological macromolecules. Its reliance on single-layered or double-layered two-dimensionally ordered arrays and the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936d6b3276ecdfab7b8917a7d208ae84
https://doi.org/10.1016/j.sbi.2012.03.006
https://doi.org/10.1016/j.sbi.2012.03.006
Autor:
Tai Huang Huang, Krasimir A. Spasov, Yuh-Ju Sun, Vinzenz M. Unger, Yi Chung Chen, Gang Dong, Kuo Wei Hung, Jai Hui Chen, Edward T. Eng, Chwan Deng Hsiao, Yi-Wei Chang
Publikováno v:
Journal of Structural Biology. 170:501-512
FeoB is a G-protein coupled membrane protein essential for Fe(II) uptake in prokaryotes. Here, we report the crystal structures of the intracellular domain of FeoB (NFeoB) from Klebsiella pneumoniae (KpNFeoB) and Pyrococcus furiosus (PfNFeoB) with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b527c8874ddd94056ae41e967ae87a4a
https://doi.org/10.1016/j.jsb.2010.01.017
https://doi.org/10.1016/j.jsb.2010.01.017
Publikováno v:
The Journal of Membrane Biology
Membrane proteins of the CTR family mediate cellular copper uptake in all eukaryotic cells and have been shown to participate in uptake of platinum-based anticancer drugs. Despite their importance for life and the clinical treatment of malignancies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53014bf15d3dbed64456b2306025b85d
https://doi.org/10.1007/s00232-010-9239-4
https://doi.org/10.1007/s00232-010-9239-4
Autor:
Franziska Bleichert, Keith T. Gagnon, E. Stuart Maxwell, Bernard A. Brown, Andres E. Leschziner, Susan J. Baserga, Vinzenz M. Unger
Publikováno v:
Science. 325:1384-1387
Seeing Double A particular set of ubiquitous small (nucleolar) ribonucleoproteins are important for optimal ribosome function and protein synthesis. Bleichert et al. (p. 1384 ) used electron microscopy and single-particle analysis to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b64b166f7cf69a8de8ec9cdac58a402d
https://doi.org/10.1126/science.1176099
https://doi.org/10.1126/science.1176099
Autor:
Gary S. Ayton, Vinod Krishna, Richard D. Swenson, Edward Lyman, Gregory A. Voth, Vinzenz M. Unger, Carsten Mim
Publikováno v:
Biophysical Journal. 97(6):1616-1625
Mesoscopic simulations and electron microscopy of N-BAR domain-induced liposome remodeling are used to characterize the process of liposome tubulation and vesiculation. The overall process of membrane remodeling is found to involve complex couplings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731f16e7ab19952ac983921c0a22d20c