Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vinutha Ganapathy"'
Autor:
Hanyu Liang, Nattapol Sathavarodom, Claudia Colmenares, Jonathan Gelfond, Sara E. Espinoza, Vinutha Ganapathy, Nicolas Musi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Studies in cell cultures and rodents suggest that TLR4 is involved in the pathogenesis of insulin resistance, but direct data in humans are limited. We tested the hypothesis that pharmacologic blockade of TLR4 with the competitive inhibito
Externí odkaz:
https://doaj.org/article/5c0a8c34b5c440e4a56bdb13893b2b01
Publikováno v:
Diabetes. 69
Obese subjects have increased levels of free fatty acids (FFA) in plasma that may mediate the inflammation and insulin resistance seen in these individuals. Data generated mostly in cells and rodents suggest that toll like receptor 4 (TLR4) mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f498c144c82d5611058edff73c089a04
https://doi.org/10.2337/db20-1735-p
https://doi.org/10.2337/db20-1735-p
Autor:
Chiara Pascucci, Vinutha Ganapathy, Chen Pin Wang, Nicolas Musi, Sara E. Espinoza, Daniel J. MacCarthy, Jessica Lee
Publikováno v:
Diabetes. 69
Obesity leads to sarcopenia and poor physical function with aging. Evidence in animals and in middle-age humans suggests that the pituitary hormone oxytocin reduces appetite, promotes weight loss, and improves glucose tolerance while preserving lean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ffdb337be84ebd9562654216e3182b3
https://doi.org/10.2337/db20-1999-p
https://doi.org/10.2337/db20-1999-p
Autor:
Nattapol Sathavarodom, Sara E. Espinoza, Nicolas Musi, Chen Pin Wang, Eric Baeuerle, Vinutha Ganapathy, Roman Fernandez, Hanyu Liang
Publikováno v:
Diabetes. 69
The human gut and its microbial content (microbiome) may contribute to the pathogenesis of obesity, insulin resistance and type 2 diabetes. Possible mechanisms include altered bacterial profile, increased intestinal permeability, and elevated bacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a10bc95aa53585be98d96ab0be524f
https://doi.org/10.2337/db20-181-or
https://doi.org/10.2337/db20-181-or
Intranasal Oxytocin Improves Lean Muscle Mass in Older Adults With Sarcopenic Obesity: A Pilot Study
Autor:
Vinutha Ganapathy, Nicolas Musi, Sara E. Espinoza, Chiara Pascucci, Adetutu Odejimi, Chen Pin Wang, Elena Volpi, Jessica Lee
Publikováno v:
Innovation in Aging
Obese older adults often have sarcopenia with increased functional impairments. Unfortunately, conventional weight loss treatments can lead to further muscle mass loss. Increasing evidence from animal studies suggests that the pituitary hormone oxyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9a125141227afde10b291ed928628c
https://doi.org/10.1093/geroni/igaa057.436
https://doi.org/10.1093/geroni/igaa057.436
Autor:
Vinutha Ganapathy, Yan Li, Rozmin Jiwani, Becky Powers, Lauri C. Kelly, Nicolas Musi, Sara E. Espinoza, Chen Pin Wang, Darcy Bair-Kelps, Terry Romo, Joel E. Michalek, Alice Conde, Melody Moris, Tyson E. Jergensen, Beverly Orsak
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 75(1)
Background Frailty is a geriatric syndrome that leads to poor health outcomes with aging. Previous studies have demonstrated that insulin resistance and inflammation predict frailty onset. Metformin is a widely used, well-tolerated drug that improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15385de24b2e025bf46f516ce4bcc700
https://pubmed.ncbi.nlm.nih.gov/30888034
https://pubmed.ncbi.nlm.nih.gov/30888034
Autor:
Beverly Orsak, Nicolas Musi, Hanyu Liang, Claudia V. Colmenares, Nattapol Sathavarodom, Vinutha Ganapathy
Publikováno v:
Innovation in Aging
Older and obese subjects have increased levels of free fatty acids (FFA) in plasma that may mediate the inflammation and insulin resistance seen in these individuals. Data generated mostly in cells and rodents suggest that toll like receptor 4 (TLR4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48e7612fb948219bcfa3c4c2ec934c8
https://doi.org/10.1093/geroni/igz038.393
https://doi.org/10.1093/geroni/igz038.393
Autor:
Chen Pin Wang, Vinutha Ganapathy, Meghan I. Short, Helen P. Hazuda, Sudha Seshadri, Mitzi M. Gonzales, Mini E. Jacob, Claudia Satizabal Barrera
Publikováno v:
Innovation in Aging
Mexican Americans (MA) have higher morbidity compared to European Americans (EA); however, the mortality rate remains lower (Hispanic Paradox). The Healthy Aging Index (HAI) captures clinical and subclinical morbidity in older adults and is useful in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b413247802976f3d69c43733a60eabb
http://europepmc.org/articles/PMC6846529
http://europepmc.org/articles/PMC6846529