Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Vinothkumar, Rajan"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Zebrafish offer an excellent tool for studying the vertebrate hematopoietic system thanks to a highly conserved and rapidly developing hematopoietic program, genetic amenability, optical transparency, and experimental accessibility. Zebrafish studies
Externí odkaz:
https://doaj.org/article/458727eeb6d842619026bf7ef4c9c546
Publikováno v:
Re:GEN Open, Vol 1, Iss 1, Pp 53-67 (2021)
Background: Knock-in of precise point mutations into protein-coding genes is among the most important applications of Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9. Precise introduction of amino acid changes is crucial to interrog
Externí odkaz:
https://doaj.org/article/182893102dff4ee6bb624489a92450b8
Autor:
Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J.V. Campbell, Todd Druley, Jason N. Berman
Publikováno v:
Haematologica, Vol 105, Iss 10 (2019)
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lack specific cytokines that mimic the microenvironment
Externí odkaz:
https://doaj.org/article/732605c4586348e6ac1df48e0a742dd0
Autor:
Michelle Moksa, Mira Liebman, Vinothkumar Rajan, Martin Hirst, Rachel Woodside, Marcus Wong, Annaick Carles, Keon Collett, Jason N. Berman, Sergey V. Prykhozhij
Publikováno v:
Leukemia. 36:809-820
TET2 loss-of-function mutations are recurrent events in a wide range of hematological malignancies and a physiologic occurrence in blood cells of healthy older adults. It is currently unknown what determines if a person harboring a somatic TET2 mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f04afa7b753177aefebdb0eb45ca608
https://doi.org/10.1038/s41375-021-01427-7
https://doi.org/10.1038/s41375-021-01427-7
Autor:
Vinothkumar Rajan, Sergey V. Prykhozhij, Aditya Pandey, Alejandro M. Cohen, Jan K. Rainey, Jason N. Berman
Publikováno v:
British journal of haematologyREFERENCES.
KIT, a type III tyrosine kinase receptor, plays a crucial role in haematopoietic development. The KIT receptor forms a dimer after ligand binding; this activates tyrosine kinase activity leading to downstream signal transduction. The D816V KIT mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875bcc88f9fac0a6f6b4ee53889b9ff0
https://pubmed.ncbi.nlm.nih.gov/35245395
https://pubmed.ncbi.nlm.nih.gov/35245395
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119372 (2015)
Genome engineering has been revolutionized by the discovery of clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated system genes (Cas) in bacteria. The type IIB Streptococcus pyogenes CRISPR/Cas9 system functions in many
Externí odkaz:
https://doaj.org/article/675bfeecef6040c8a878fc837d602dad
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138634 (2015)
Externí odkaz:
https://doaj.org/article/ece386611eb94c04b6afb3e8ff580794
Autor:
Vinothkumar, Rajan, Keon, Collett, Rachel, Woodside, Sergey V, Prykhozhij, Michelle, Moksa, Annäick, Carles, Marcus, Wong, Mira, Liebman, Martin, Hirst, Jason N, Berman
Publikováno v:
Leukemia. 36(3)
TET2 loss-of-function mutations are recurrent events in a wide range of hematological malignancies and a physiologic occurrence in blood cells of healthy older adults. It is currently unknown what determines if a person harboring a somatic TET2 mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8cbf6783098cf6846834e3eb43ac349
https://pubmed.ncbi.nlm.nih.gov/34588613
https://pubmed.ncbi.nlm.nih.gov/34588613
Autor:
Nicole Melong, Clinton J. V. Campbell, Troy C. Lund, Wing Hing Wong, Todd E. Druley, Nitin Mahajan, Benjamin King, Vinothkumar Rajan, R. Spencer Tong, David Rittenberg, Daniel Gaston, Jason N. Berman, Graham Dellaire
Publikováno v:
Haematologica
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lacks specific cytokines that mimic the microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922a651c648d7839bca442c0d314559e
http://europepmc.org/articles/PMC7556680
http://europepmc.org/articles/PMC7556680
Publikováno v:
Zebrafish. 13:70-73
The development of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology for mainstream biotechnological use based on its discovery as an adaptive immune mechanism in bacteria has dramatically improved the ability of mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4744fb3ef01b1ebc015ff08b2799b639
https://doi.org/10.1089/zeb.2015.1158
https://doi.org/10.1089/zeb.2015.1158