Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Vinod Subramaniam"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
N-α-acetylation is a frequently occurring post-translational modification in eukaryotic proteins. It has manifold physiological consequences on the regulation and function of several proteins, with emerging studies suggesting that it is a global reg
Externí odkaz:
https://doaj.org/article/1ddb08617bef4ca19d9588ca67d9fd98
Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Although the function of biopolymer hydrogels in nature depends on structural anisotropy at mesoscopic length scales, the self-assembly of such anisotropic structures in vitro is challenging. Here we show that fibrils of the protein α-synuc
Externí odkaz:
https://doaj.org/article/1596bfc132534431bae186e64f01ebf2
Autor:
Gustavo A. Higuera, Hugo Fernandes, Tim W.G.M. Spitters, Jeroen van de Peppel, Nils Aufferman, Roman Truckenmueller, Maryana Escalante, Reinout Stoop, Johannes P van Leeuwen, Jan de Boer, Vinod Subramaniam, Marcel Karperien, Clemens van Blitterswijk, Anton van Boxtel, Lorenzo Moroni
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 84-94 (2015)
This data article contains seven figures and two tables supporting the research article entitled: spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo [1]. T
Externí odkaz:
https://doaj.org/article/4ebcdc6a2f7e428abdf4344794dfe859
Autor:
Mihaela M Apetri, Rolf Harkes, Vinod Subramaniam, Gerard W Canters, Thomas Schmidt, Thijs J Aartsma
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153020 (2016)
Aggregation of α-synuclein has been linked to both familial and sporadic Parkinson's disease. Recent studies suggest that α-synuclein aggregates may spread from cell to cell and raise questions about the propagation of neurodegeneration. While cont
Externí odkaz:
https://doaj.org/article/1a54ddfcb0ec41d7888d3f41e5d88474
Autor:
Marie Brázdová, Vlastimil Tichý, Robert Helma, Pavla Bažantová, Alena Polášková, Aneta Krejčí, Marek Petr, Lucie Navrátilová, Olga Tichá, Karel Nejedlý, Martin L Bennink, Vinod Subramaniam, Zuzana Bábková, Tomáš Martínek, Matej Lexa, Matej Adámik
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167439 (2016)
Triplex DNA is implicated in a wide range of biological activities, including regulation of gene expression and genomic instability leading to cancer. The tumor suppressor p53 is a central regulator of cell fate in response to different type of insul
Externí odkaz:
https://doaj.org/article/b3f101886c88485e8b58765be1c7d627
Autor:
Christian Blum, Frank Schleifenbaum, Martijn Stopel, Sébastien Peter, Marcus Sackrow, Vinod Subramaniam, Alfred J. Meixner
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 2, Iss 1, Pp 516-524 (2011)
We report a single molecule detection scheme to investigate excitation spectra of single emitters at room temperature. We demonstrate the potential of single emitter photoluminescence excitation spectroscopy by recording excitation spectra of single
Externí odkaz:
https://doaj.org/article/198dae9cf9834a5383a5eef71a29a102
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142795 (2015)
Binding of human α-Synuclein, a protein associated with Parkinson's disease, to natural membranes is thought to be crucial in relation to its pathological and physiological function. Here the binding of αS to small unilamellar vesicles mimicking th
Externí odkaz:
https://doaj.org/article/a8e74bee0e96432ead13645673c60bd4
Autor:
Andrea M Pereira, Cicerone Tudor, Philippe-Alexandre Pouille, Shashank Shekhar, Johannes S Kanger, Vinod Subramaniam, Enrique Martín-Blanco
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101963 (2014)
Cells display versatile responses to mechanical inputs and recent studies have identified the mitogen-activated protein kinase (MAPK) cascades mediating the biological effects observed upon mechanical stimulation. Although, MAPK pathways can act insu
Externí odkaz:
https://doaj.org/article/185f4056751e4bdd892d64f1a3b359e2
Autor:
Andrea Maria Pereira, Cicerone Tudor, Johannes S Kanger, Vinod Subramaniam, Enrique Martin-Blanco
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e26182 (2011)
Mechanical force is known to modulate the activity of the Jun N-terminal kinase (JNK) signaling cascade. However, the effect of mechanical stresses on JNK signaling activation has previously only been analyzed by in vitro detection methods. It still
Externí odkaz:
https://doaj.org/article/66ef3ec5833140b49d84f86e6d15abcf
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14292 (2010)
The question of how the aggregation of the neuronal protein α-synuclein contributes to neuronal toxicity in Parkinson's disease has been the subject of intensive research over the past decade. Recently, attention has shifted from the amyloid fibrils
Externí odkaz:
https://doaj.org/article/4a64d1945ed24396bbba0486107d6df3