Výsledky vyhledávání

Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies

Autor: Vishal Unadkat, Shishir Rohit, Paranjay Parikh, Kaushal Patel, Vinod Sanna, Sanjay Singh

Publikováno v: OncoTargets and therapy. 15

Vishal Unadkat,1,2 Shishir Rohit,1 Paranjay Parikh,3 Kaushal Patel,3 Vinod Sanna,4 Sanjay Singh2,5 1Kashiv Biosciences Pvt Ltd, Ahmedabad, 382210, Gujarat, India; 2Division of Biological & Life Sciences (Formerly Institute of Life Sciences), School o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace9393c88ba09040cb04dfb801d23a
https://pubmed.ncbi.nlm.nih.gov/35535170

Zobrazit plný text záznamu

Plný text ve formátu HTML

Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors

Autor: Vishal Unadkat, Sanjay Singh, Shishir Rohit, Paranjay Parikh, Vinod Sanna

Publikováno v: Bioorganic chemistry. 114

A molecular dynamics-based sampling of epidermal growth factor receptor tyrosine kinase (EGFR-TK) was carried out to search for energetically more stable protein, which was then used for molecular docking of a series of 1,2,4-oxadiazole derivatives p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b7da1cd5e8bc9c264a4a17b715054a
https://pubmed.ncbi.nlm.nih.gov/34768203

Zobrazit plný text záznamu

Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors

Autor: Takashi Kurohara, Piyush Gediya, Varalakshmi Raguraman, Debarpan Ghosh, Manjunath Ghate, Lucia Altucci, Vincenzo Carafa, Nikum D. Sitwala, Vinod Sanna, K. Suthindhiran, Angelita Poziello, Laura Della Torre, Dhiraj Bhatia, Takayoshi Suzuki, Vivek K. Vyas

Publikováno v: Bioorganic chemistry. 110

The discovery and development of isoform-selective histone deacetylase (HDAC) inhibitor is a challenging task because of the sequence homology among HDAC enzymes. In the present work, novel tetrahydro benzo[b]thiophene-3-carbonitrile based benzamides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdaffa6b43b33a9dcabbdd92a57c5a2
https://pubmed.ncbi.nlm.nih.gov/33756235

Zobrazit plný text záznamu

Corrigendum to 'Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors' [Bioorg. Chem. 114 (2021) 105124]

Autor: Kaushal P. Patel, Sanjay Singh, Vishal Unadkat, Paranjay Parikh, Vinod Sanna, Shishir Rohit

Publikováno v: Bioorganic Chemistry. 117:105459

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04f153efc6c977ca15ab4c667b968f59
https://doi.org/10.1016/j.bioorg.2021.105459

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání