Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Vinod K. Batra"'
Autor:
Vinod K. Batra, Samuel H. Wilson
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-4 (2020)
Communications Biology
Communications Biology
Adenine frequently pairs with the Hoogsteen edge of an oxidized guanine base (8OG) causing G to T transversions. The (syn)8OG:dA base pair is indistinguishable from the cognant base pair and can be extended by DNA polymerases with reduced efficiency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746accacade7924822037eb7072f7479
http://link.springer.com/article/10.1038/s42003-020-1080-4
http://link.springer.com/article/10.1038/s42003-020-1080-4
Autor:
Charles E. McKenna, Khadijeh S. Alnajjar, Vinod K. Batra, Myron F. Goodman, Samuel H. Wilson, Joann B. Sweasy
Publikováno v:
Biochemistry
The human DNA polymerase (pol) β cancer variant K289M has altered polymerase activity in vitro, and the structure of wild-type pol β reveals that the K289 side chain contributes to a network of stabilizing interactions in a C-terminal region of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8593501517968ab3e4754623f5b108
https://doi.org/10.1021/acs.biochem.9b01072
https://doi.org/10.1021/acs.biochem.9b01072
Autor:
Samuel H. Wilson, Boris A. Kashemirov, Myron F. Goodman, Keriann Oertell, William A. Beard, Charles E. McKenna, Vinod K. Batra
Publikováno v:
Biochemistry. 57:3934-3944
We report high-resolution crystal structures of DNA polymerase (pol) β in ternary complex with a panel of incoming dNTPs carrying acidity-modified 5'-triphosphate groups. These novel dNTP analogues have a variety of halomethylene substitutions repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ae10a7c760452562956ec07127955f
https://doi.org/10.1021/acs.biochem.8b00418
https://doi.org/10.1021/acs.biochem.8b00418
Autor:
William A. Beard, Vinod K. Batra, Nisha A. Cavanaugh, David D. Shock, Michael J. Howard, Samuel H. Wilson
Publikováno v:
J Biol Chem
DNA polymerase β has two DNA-binding domains that interact with the opposite sides of short DNA gaps. These domains contribute two activities that modify the 5' and 3' margins of gapped DNA during base excision repair. DNA gaps greater than 1 nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d86b0e11f91053f7d932430f16540
https://pubmed.ncbi.nlm.nih.gov/31801827
https://pubmed.ncbi.nlm.nih.gov/31801827
Publikováno v:
J Biol Chem
DNA methylation is an epigenetic mark that regulates gene expression in mammals. One method of methylation removal is through ten-eleven translocation-catalyzed oxidation and the base excision repair pathway. The iterative oxidation of 5-methylcytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe348380aa8b835e336e92a2a06a459
https://europepmc.org/articles/PMC6509498/
https://europepmc.org/articles/PMC6509498/
Autor:
Corinne Minard, Vinod K. Batra, Myron F. Goodman, Amirsoheil Negahbani, Boris A. Kashemirov, Joann B. Sweasy, Keriann Oertell, Khadijeh S. Alnajjar, William A. Beard, Samuel H. Wilson, Pouya Haratipour, Charles E. McKenna
Publikováno v:
Biochemistry. 57(26)
We examine the DNA polymerase β (pol β) transition state from a leaving group presteady-state kinetics perspective by measuring the rate of incorporation of dNTPs and corresponding novel β,γ-CXY-dNTP analogues, including individual β,γ-CHF and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccddb464b93e833250daed33346fdfff
https://pubmed.ncbi.nlm.nih.gov/29889506
https://pubmed.ncbi.nlm.nih.gov/29889506
Autor:
Lars C. Pedersen, Lee G. Pedersen, David D. Shock, Vinod K. Batra, Lalith Perera, Samuel H. Wilson, William A. Beard, Ping Lin
Publikováno v:
Journal of the American Chemical Society. 135:8078-8088
DNA polymerase β (pol β) is a bifunctional enzyme widely studied for its roles in base excision DNA repair where one key function is gap-filling DNA synthesis. In spite of significant progress in recent years, the atomic level mechanism of the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edfa8bb83004f88e8e97ceec9a1cd76
https://doi.org/10.1021/ja403842j
https://doi.org/10.1021/ja403842j
Publikováno v:
Structure (London, England : 1993). 24(11)
High-fidelity DNA synthesis requires that polymerases display a strong preference for right nucleotide insertion. When the wrong nucleotide is inserted, the polymerase deters extension from the mismatched DNA terminus. Twenty-three crystallographic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89922b531160427419207c73971156da
https://pubmed.ncbi.nlm.nih.gov/27806256
https://pubmed.ncbi.nlm.nih.gov/27806256
Publikováno v:
Molecular Biology. 45:536-550
The current “working model” for mammalian base excision repair involves two sub-pathways termed single-nucleotide base excision repair and long patch base excision repair that are distinguished by their repair patch sizes and the enzymes/co-facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a0518cc847147ce7fc64ef1ee2b6e5
https://doi.org/10.1134/s0026893311040091
https://doi.org/10.1134/s0026893311040091
Autor:
Boris A. Kashemirov, Myron F. Goodman, Thomas G. Upton, Charles E. McKenna, William A. Beard, Lars C. Pedersen, Vinod K. Batra, Samuel H. Wilson
Publikováno v:
Journal of the American Chemical Society. 132:7617-7625
β,γ-Fluoromethylene analogues of nucleotides are considered to be useful mimics of the natural substrates, but direct structural evidence defining their active site interactions has not been available, including the influence of the new chiral cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82c1dbb3d39d69dd4cb04bfba8f92ed
https://doi.org/10.1021/ja909370k
https://doi.org/10.1021/ja909370k