Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Vinod, Khetarpal"'
Autor:
Frank Herrmann, Manuela Hessmann, Sabine Schaertl, Karola Berg-Rosseburg, Christopher J Brown, Galina Bursow, Anass Chiki, Andreas Ebneth, Miriam Gehrmann, Nicole Hoeschen, Madlen Hotze, Stefanie Jahn, Peter D Johnson, Vinod Khetarpal, Alex Kiselyov, Karsten Kottig, Stefanie Ladewig, Hilal Lashuel, Sven Letschert, Matthew R Mills, Kathrin Petersen, Michael E Prime, Christoph Scheich, Gerhard Schmiedel, John Wityak, Longbin Liu, Celia Dominguez, Ignacio Muñoz-Sanjuán, Jonathan A Bard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mH
Externí odkaz:
https://doaj.org/article/9ab72a1e5e324d34b23c0110b93bbd78
Autor:
Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi-Impiombato, Kimberly Kerker, Kim Cirillo, Mukesh Bansal, Rich Mushlin, Daniela Brunner, Sylvie Ramboz, Mei Kwan, Kirsten Kuhlbrodt, Karsten Tillack, Finn Peters, Leena Rauhala, John Obenauer, Jonathan R. Greene, Christopher Hartl, Vinod Khetarpal, Brenda Lager, Jim Rosinski, Jeff Aaronson, Morshed Alam, Ethan Signer, Ignacio Muñoz-Sanjuán, David Howland, Scott O. Zeitlin
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
We have developed an inducible Huntington’s disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant huntingtin (mHtt) expression. We asked whether moderate global lowering of mHtt (~50%) was sufficient for long-te
Externí odkaz:
https://doaj.org/article/134f08ad54bc41838bc7ff1320c3e0ea
Autor:
Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Antonella Cellucci, Giulio Auciello, Maria Rosaria Battista, Isabelle Gloaguen, Silvia Fortuni, Cristina Cariulo, Vinod Khetarpal, Celia Dominguez, Ignacio Muñoz-Sanjuán, Annalise Di Marco
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7813 (2022)
While blood–brain barrier (BBB) dysfunction has been described in neurological disorders, including Huntington’s disease (HD), it is not known if endothelial cells themselves are functionally compromised when promoting BBB dysfunction. Furthermor
Externí odkaz:
https://doaj.org/article/270c5f78ddb04b92bb989dab36bd3230
Autor:
Longbin Liu, Peter D. Johnson, Michael E. Prime, Vinod Khetarpal, Christopher J. Brown, Luca Anzillotti, Daniele Bertoglio, Xuemei Chen, Samuel Coe, Randall Davis, Anthony P. Dickie, Simone Esposito, Elise Gadouleau, Paul R. Giles, Catherine Greenaway, James Haber, Christer Halldin, Scott Haller, Sarah Hayes, Todd Herbst, Frank Herrmann, Manuela Heßmann, Ming Min Hsai, Yaser Khani, Adrian Kotey, Angelo Lembo, John E. Mangette, Gwendolyn A. Marriner, Richard W. Marston, Matthew R. Mills, Edith Monteagudo, Anton Forsberg-Morén, Sangram Nag, Laura Orsatti, Christine Sandiego, Sabine Schaertl, Joanne Sproston, Steven Staelens, Jack Tookey, Penelope A. Turner, Andrea Vecchi, Maria Veneziano, Ignacio Muñoz-Sanjuan, Jonathan Bard, Celia Dominguez
Publikováno v:
Journal of Medicinal Chemistry. 66:641-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e78d658107fd1300b7add11eee0911
https://doi.org/10.1021/acs.jmedchem.2c01585
https://doi.org/10.1021/acs.jmedchem.2c01585
Autor:
Aline Delva, Michel Koole, Kim Serdons, Guy Bormans, Longbin Liu, Jonathan Bard, Vinod Khetarpal, Celia Dominguez, Ignacio Munoz-Sanjuan, Andrew Wood, Mette Skinbjerg, Yuchuan Wang, Wim Vandenberghe, Koen Van Laere
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:48-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5afa02a45f731ba77f5c67fe806fabf
https://doi.org/10.1007/s00259-022-05945-z
https://doi.org/10.1007/s00259-022-05945-z
Autor:
Vinod Khetarpal, Todd Herbst, Shahzad Akhtar, Amber LaFayette, Dennis Miller, James Farnham, Troy Steege, Zhixin Miao, Bryan Marks, Aaron Ledvina, Celia Dominguez
Publikováno v:
Bioanalysis.
Background: Dysregulation of the kynurenine metabolic pathway has been reported in several neurological conditions. Methods & results: Sensitive and selective LC–MS/MS methods have been validated for six kynurenine pathway metabolites in human cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b0eee84b5a4ab4645745364aa8b17a
https://doi.org/10.4155/bio-2023-0016
https://doi.org/10.4155/bio-2023-0016
Autor:
Annalise Di Marco, Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Maria Rosaria Battista, Antonella Cellucci, Elena Bracacel, Giulio Auciello, Maria Veneziano, Vinod Khetarpal, Mark Rose, Alessandro Rosa, Isabelle Gloaguen, Edith Monteagudo, Todd Herbst, Celia Dominguez, Ignacio Muñoz-Sanjuán
Publikováno v:
Cells, Vol 9, Iss 4, p 994 (2020)
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the o
Externí odkaz:
https://doaj.org/article/d4344a862cc142e2914339bfced09308
Autor:
Vinod Khetarpal, Celia Dominguez, Leonie Wyffels, Ignacio Munoz-Sanjuan, Jeroen Verhaeghe, Alan Miranda, Longbin Liu, Steven Staelens, Daniele Bertoglio, Ladislav Mrzljak, Jonathan Bard, Mette Skinbjerg, Sigrid Stroobants
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:1166-1175
Purpose As several therapies aimed at lowering mutant huntingtin (mHTT) brain levels in Huntington’s disease (HD) are currently being investigated, noninvasive positron emission tomography (PET) imaging of mHTT could be utilized to directly evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e834ba76cf2f9cb693061c41b4ec6151
https://doi.org/10.1007/s00259-021-05578-8
https://doi.org/10.1007/s00259-021-05578-8
Autor:
Vinod Khetarpal, Todd Herbst, Michael E. Fitzsimmons, Celia Dominguez, Diana Shefchek, Mark Gohdes, Steven Ash, Ignacio Munoz-Sanjuan
Publikováno v:
Xenobiotica. 51:1155-1180
The disposition of a novel kynurenine monooxygenase inhibitor, CHDI-340246, was investigated in vitro and in animals.In vitro, there was minimal metabolic turnover of CHDI-340246 in all species. The protein binding was higher in human plasma (99.7%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679ccf3378aebc32cb75ee60712d013b
https://doi.org/10.1080/00498254.2021.1977868
https://doi.org/10.1080/00498254.2021.1977868
Autor:
Madlen Hotze, Miriam Gehrmann, Manuela Hessmann, Longbin Liu, Christoph Scheich, Kathrin Petersen, Nicole Hoeschen, Peter Johnson, Sabine Schaertl, Stefanie Jahn, Matthew R. Mills, Ignacio Munoz-Sanjuan, Alex S. Kiselyov, John Wityak, Anass Chiki, Vinod Khetarpal, Karsten Kottig, Gerhard Schmiedel, Galina Bursow, Stefanie Ladewig, Christopher J. Brown, Karola Berg-Rosseburg, Michael Prime, Sven Letschert, Andreas Ebneth, Jonathan Bard, Celia Dominguez, Frank Herrmann, Hilal A. Lashuel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports
Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mHTT) under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a157f6eee06d07d3c18e1c6daf1e927b
https://doaj.org/article/9ab72a1e5e324d34b23c0110b93bbd78
https://doaj.org/article/9ab72a1e5e324d34b23c0110b93bbd78