Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vinochani Pillay"'
Autor:
Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a devastating si
Externí odkaz:
https://doaj.org/article/606001842ee84fea84121c90aaec3c6e
Autor:
Vinochani Pillay, Layal Allaf, Alexander L. Wilding, Jacqui F. Donoghue, Naomi W. Court, Steve A. Greenall, Andrew M. Scott, Terrance G. Johns
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 5, Pp 448-458 (2009)
A common mutation of the epidermal growth factor receptor (EGFR) in glioblastoma multiforme (GBM) is an extracellular truncation known as the de2-7 EGFR (or EGFRvIII). Hepatocyte growth factor (HGF) is the ligand for the receptor tyrosine kinase (RTK
Externí odkaz:
https://doaj.org/article/1086668e9fe3428ba71bc3f816ce02a5
Autor:
Georgia A. Corner, Vinochani Pillay, Richard J. Simpson, Hong Ji, Sze Ting Lee, Robert Speirs, Andrew M. Scott, Kai Stühler, Terrance Grant Johns, Angela A. Vitali, David W. Greening, Carmel Murone, Angela Rigopoulos, John M. Mariadason
An important mediator of tumorigenesis, the epidermal growth factor receptor (EGFR) is expressed in almost all non-transformed cell types, associated with tumor progression, angiogenesis and metastasis. The significance of the EGFR as a cancer therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e789ad4f4e4dd608a8a217a32644745b
Publikováno v:
New Biotechnology. 28:518-529
Monoclonal antibodies (mAbs) have become one of the largest classes of new therapeutic agents approved for use in oncology, and have revolutionised the treatment of many human malignancies. Clinically useful mAbs can function through several differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98768815ad11bbbf1727bcf03f9f3547
https://doi.org/10.1016/j.nbt.2011.03.021
https://doi.org/10.1016/j.nbt.2011.03.021
Autor:
Adel Garas, Vinochani Pillay, Donald G. MacPhee, Hilary Zeller, Richard G.H. Cotton, William A. Denny, Elizabeth Webb
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 678:20-29
We report the development of a simple, cost-effective assay for detecting compounds that have the ability to interact with and modify DNA. Potential uses for the assay lie in the areas of early genotoxicity testing of drug candidates, anticancer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772d70475e8af152441dd7e7aa1a7ec2
https://doi.org/10.1016/j.mrgentox.2009.06.005
https://doi.org/10.1016/j.mrgentox.2009.06.005
Autor:
Suzanne M. Cutts, Robert A. Forrest, Don R. Phillips, Abraham Nudelman, Ada Rephaeli, Lonnie P. Swift, Vinochani Pillay
Publikováno v:
Molecular Cancer Therapeutics. 6:1450-1459
The anthracycline group of compounds is extensively used in current cancer chemotherapy regimens and is classified as topoisomerase II inhibitor. However, previous work has shown that doxorubicin can be activated to form DNA adducts in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7299743ddef87ee9bdd0a06e236fddb
https://doi.org/10.1158/1535-7163.mct-06-0551
https://doi.org/10.1158/1535-7163.mct-06-0551
Publikováno v:
Trends in Biotechnology. 25:33-39
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. Impairment of uPA and/or uPAR function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7647fa5d229af2071bc67257dd4698
https://doi.org/10.1016/j.tibtech.2006.10.011
https://doi.org/10.1016/j.tibtech.2006.10.011
Publikováno v:
Journal of Cellular Biochemistry. 69:463-469
Rat hepatoma cells lacking mitochondrial DNA (rho(o) cells) were used as a model system to examine the possible roles of mitochondrial DNA as a target for the DNA-acting anticancer drug Adriamycin (doxorubicin). The rho(o) cells were 45-fold less sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d00df46883d9590b28d301eb7a0c732
https://doi.org/10.1002/(sici)1097-4644(19980615)69:4<463::aid-jcb7>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19980615)69:4<463::aid-jcb7>3.0.co
Autor:
Otavia L. Caballero, Vinochani Pillay, Richard Jove, Yuelong Ma, Piotr Swiderski, Andrew M. Scott, David Horne, Claudia M. Kowolik, Fook-Thean Lee, Andrew J. G. Simpson, Hua Yu, Marcin Kortylewski
Publikováno v:
ACS chemical biology. 6(9)
The clinical application of siRNA is limited largely by the lack of efficient, cell-specific delivery systems. Antibodies are attractive delivery vehicles for targeted therapy due to their high specificity. In this study we describe the use of a huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c92aeeaf28cefdb8c0fb3964966758
https://pubmed.ncbi.nlm.nih.gov/21766840
https://pubmed.ncbi.nlm.nih.gov/21766840
Publikováno v:
Journal of microbiological methods. 84(1)
Canola is second only to soybean as the most important oilseed crop in the world. The global production of canola is forecast to continue to increase and as a result the canola industry will continue to flourish. However, it is threatened by several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608a770f87e723223322e1247c3efa79
https://pubmed.ncbi.nlm.nih.gov/21093501
https://pubmed.ncbi.nlm.nih.gov/21093501