Genome-wide association study identifies 48 common genetic variants associated with handedness

Autor: Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, de Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, van Duijn, Cornelia M, van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, Medland, Sarah E

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, w

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https://www.repository.cam.ac.uk/handle/1810/309425

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Genome-wide association study identifies 48 common genetic variants associated with handedness.

Autor: Cuellar-Partida G; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.; 23andMe, Inc., Sunnyvale, CA, USA., Tung JY; 23andMe, Inc., Sunnyvale, CA, USA., Eriksson N; 23andMe, Inc., Sunnyvale, CA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Aliev F; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.; Karabuk University, Faculty of Business, Karabük, Turkey., Andreassen OA; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Barroso I; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Beckmann JS; Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Boks MP; Department of Psychiatry, UMC Utrecht Brain Center, University Utrecht, Utrecht, The Netherlands., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Breteler MMB; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Campbell H; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cherkas LF; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Davies G; Department of Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., de Geus EJC; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Deary IJ; Department of Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health, Queen Mary University of London, London, UK., Dick DM; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA., Duffy DL; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Neuherberg, Germany., Giegling I; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Gordon SD; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Han J; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA., Hansen TF; Institute of Biological Psychiatry, Mental Health Services of Copenhagen, Copenhagen, Denmark.; Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark., Hartmann AM; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Heikkilä K; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Hirschhorn JN; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hwang LD; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Kaprio J; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kemp JP; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Khaw KT; Public Health and Primary Care, University of Cambridge, Cambridge, UK., Klopp N; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany., Konte B; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Kutalik Z; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.; Turku Institute for Advanced Studies, University of Turku, Turku, Finland.; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Li X; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luciano M; Department of Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Magnusson SH; deCODE Genetics, Reykjavik, Iceland., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McArdle WL; Bristol Medical School, University of Bristol, Bristol, UK., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.; Human Genetics, Genentech, South San Francisco, CA, USA., Medina-Gomez C; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Melville SA; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mooser V; Service of Clinical Chemistry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Nelis M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Nyholt DR; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., O'Connell KS; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ophoff RA; Department of Human Genetics, University California Los Angeles, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University California Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands., Palmer C; Department of Computer Science, Columbia University, New York, NY, USA., Palotie A; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Palviainen T; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Pare G; Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Paternoster L; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Peltonen L; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Penninx BWJH; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Department of Psychiatry, Amsterdam UMC, VU University, Amsterdam, The Netherlands., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia.; Research Unit, Psychiatric Hospital Sveti Ivan, Zagreb, Croatia., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Prokopenko I; Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.; Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK., Raikkonen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Ripatti S; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Rivadeneira F; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Rudan I; Centre for Global Health Research, The Usher Institute, University of Edinburgh, Edinburgh, UK., Rujescu D; University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Smit JH; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Department of Psychiatry, Amsterdam UMC, VU University, Amsterdam, The Netherlands., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Smoller JW; Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA., Soranzo N; Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Max Planck Institute for Psycholinguistics, Wundtlaan, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Starr JM; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemilogy, University of Edinburgh, Edinburgh, UK., Stefánsson H; deCODE Genetics, Reykjavik, Iceland., Steinberg S; deCODE Genetics, Reykjavik, Iceland., Teder-Laving M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Stefánsson K; deCODE Genetics, Reykjavik, Iceland., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Uitterlinden AG; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van Rooij FJA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Vink JM; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Vuoksimaa E; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Waeber G; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Warrington N; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Waterworth D; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA., Werge T; Institute of Biological Psychiatry, Mental Health Services of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation's IPSYCH Initiative, Copenhagen, Denmark., Wichmann HE; Institute of Epidemiology, Helmholtz Center, Munich, Germany., Widen E; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Wright MJ; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia., Xu M; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Kraft P; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA., Hinds DA; 23andMe, Inc., Sunnyvale, CA, USA., Lindgren CM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Evans DM; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia. d.evans1@uq.edu.au.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. d.evans1@uq.edu.au., Medland SE; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia. Sarah.Medland@qimrberghofer.edu.au.; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Sarah.Medland@qimrberghofer.edu.au.

Publikováno v: Nature human behaviour [Nat Hum Behav] 2021 Jan; Vol. 5 (1), pp. 59-70. Date of Electronic Publication: 2020 Sep 28.