Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty

Autor: Jørgen Krohn, Vinita Rangroo Thrane, Cecilie Bergo, Hildegunn Halvorsen, Alexander S. Thrane

Publikováno v: Journal of Glaucoma. 29:280-286

PReCIS:: Adjuvant diclofenac and apraclonidine eye drop given in conjunction with selective laser trabeculoplasty (SLT) do not significantly impact medium-term intraocular pressure (IOP) reduction compared with placebo, but apraclonidine can be used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dce1826ad2f0129afab2d8b71e919d6
https://doi.org/10.1097/ijg.0000000000001457

Filtering the muddied waters of brain edema

Autor: Vinita Rangroo Thrane, Benjamin A. Plog, Alexander S. Thrane

Publikováno v: Trends in Neurosciences. 38:333-335

A central puzzle in our understanding of aquaporin 4 (AQP4) is the observation that paravascular astrocytic end-feet express abundant AQP4, whereas the cerebral microvessels they abut express tight junctions and no known aquaporins [1]. Much of previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971e19f0c874c9cc017f43a0d1c0c4c3
https://doi.org/10.1016/j.tins.2015.04.009

Critical role of aquaporin-4 (AQP4) in astrocytic Ca 2+ signaling events elicited by cerebral edema

Autor: Arne Klungland, Vinita Rangroo Thrane, Takumi Fujita, Rune Enger, Phillip M. Rappold, Ole Petter Ottersen, Alexander S. Thrane, Takahiro Takano, Fushun Wang, Arnulfo Torres, Nadia Nabil Haj-Yasein, Torgeir Holen, Weiguo Peng, Øivind Skare, Lane K. Bekar, Erlend A. Nagelhus

Publikováno v: Proceedings of the National Academy of Sciences. 108:846-851

Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here, we provide evidence that brain swelling triggers Ca 2+ signaling in astrocytes and that deletion of the Aqp4 gene markedly interferes with these events. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703149383966abfcfe7b58a1f1b05cc8
https://doi.org/10.1073/pnas.1015217108

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

Autor: Nanhong Lou, Douglas Zeppenfeld, Vinita Rangroo Thrane, Erlend A. Nagelhus, Alexander S. Thrane, Qiwu Xu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 109(46)

Calcium signaling represents the principle pathway by which astrocytes respond to neuronal activity. General anesthetics are routinely used in clinical practice to induce a sleep-like state, allowing otherwise painful procedures to be performed. Anes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4548e360f24fb8276145456999fa806
https://pubmed.ncbi.nlm.nih.gov/23112168

Ammonia toxicity: from head to toe?

Autor: Rajeshwar P. Mookerjee, Veronika Rackayova, Srinivasan Dasarathy, Balasubramaniyan Vairappan, Peter Ott, Christopher F. Rose, Vinita Rangroo Thrane

Publikováno v: Metab Brain Dis
Dasarathy, S, Mookerjee, R P, Rackayova, V, Rangroo Thrane, V, Vairappan, B, Ott, P & Rose, C F 2017, ' Ammonia toxicity : from head to toe? ', Metabolic Brain Disease, vol. 32, no. 2, pp. 529-538 . https://doi.org/10.1007/s11011-016-9938-3

Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cc15d242f366aa022256c59bab3b31
https://infoscience.epfl.ch/record/227676