Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Vinita R Joshi"'
Autor:
Vinita R Joshi, Ruchi M Newman, Melissa L Pack, Karen A Power, James B Munro, Ken Okawa, Navid Madani, Joseph G Sodroski, Aaron G Schmidt, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008577 (2020)
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the g
Externí odkaz:
https://doaj.org/article/e3859f10b003443bab3cc267b1c5c2ec
Autor:
Brian D. Quinlan, Michael Farzan, Vinita R. Joshi, Matthew R. Gardner, Christoph H. Fellinger, Neha R. Prasad, Amber S. Zhou, Hema R. Kondur
Publikováno v:
Journal of Virology. 90:7822-7832
The HIV-1 envelope glycoprotein (Env) is a trimer of gp120/gp41 heterodimers that mediates viral entry. Env binds cellular CD4, an association which stabilizes a conformation favorable to its subsequent association with a coreceptor, typically CCR5 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff953623c641d15c509b4b729146465
https://doi.org/10.1128/jvi.00803-16
https://doi.org/10.1128/jvi.00803-16
Autor:
Ernest S. Neale, Julie M. Decker, Jessica J. Chiang, Hugo Mouquet, Sebastian P. Fuchs, Christoph H. Fellinger, Vinita R. Joshi, José M. Martinez-Navio, Matthew R. Gardner, Michael Piatak, Dennis R. Burton, Jason Gorman, Michael D. Alpert, Peter D. Kwong, Charles C. Bailey, Paula M. Cannon, Hema R. Kondur, Michael Farzan, Beatrice H. Hahn, Ronald C. Desrosiers, Michel C. Nussenzweig, Annie Y. Yao, Pascal Poignard, Michael S. Seaman, Brian D. Quinlan, Lisa M. Kattenhorn, Kevin G. Haworth, Tatyana Dorfman, Guangping Gao, Markus von Schaewen, David T. Evans, Baoshan Zhang, Jeffrey D. Lifson, Alexander Ploss
Publikováno v:
Nature
The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8bde82f2803106cecbcfb52d44bb2a
http://europepmc.org/articles/PMC4352131
http://europepmc.org/articles/PMC4352131
Publikováno v:
Journal of Biological Chemistry
Phage display is a key technology for the identification and maturation of high affinity peptides, antibodies, and other proteins. However, limitations of bacterial expression restrict the range and sensitivity of assays that can be used to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bbd3f51f5177ce68407ce217c475cf
https://doi.org/10.1074/jbc.m113.452839
https://doi.org/10.1074/jbc.m113.452839