Výsledky vyhledávání

Dramatic response to cyclin D–dependent kinase 4/6 inhibitor in refractory poorly differentiated neuroendocrine carcinoma of the breast

Autor: Allison Shanks, Vinit Karur, Julia Choi

Publikováno v: Baylor University Medical Center Proceedings. 31:352-354

Neuroendocrine tumors are a rare subset of breast carcinomas. Commonly, platinum-based doublet is used as a systemic treatment option for high-grade neuroendocrine carcinomas from lung, gastrointestinal, and genitourinary origins. In comparison to ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b686c073dadf8aacf7f70e17476188f
https://doi.org/10.1080/08998280.2018.1463041

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DYRK3 Dual-specificity Kinase Attenuates Erythropoiesis during Anemia

Autor: Arvind Dev, Kim Rance, Estelle Houde, Haydn M. Prosser, Evelyn Grau, Vinit Karur, Olga Bogacheva, Madhu P. Menon, Elizabeth I. Valoret, Susan J. Pickering, George P. Livi, Oleg Bogachev, Connie L. Erickson-Miller, Don M. Wojchowski, Caretha L. Creasy

Publikováno v: Journal of Biological Chemistry. 283:36665-36675

During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. Less is understood concerning factors that limit this process. Experiments performed using dual-specificity tyrosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec10cb5e04239befc6bc27788f69a09
https://doi.org/10.1074/jbc.m807844200

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Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis

Autor: Don M. Wojchowski, Oleg Bogachev, Vinit Karur, Bethany Cuetara, Madhu P. Menon, Olga Bogacheva

Publikováno v: Journal of Clinical Investigation. 116:683-694

Anemia due to chronic disease or chemotherapy often is ameliorated by erythropoietin (Epo). Present studies reveal that, unlike steady-state erythropoiesis, erythropoiesis during anemia depends sharply on an Epo receptor-phosphotyrosine-343-Stat5 sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d72a51fe1366f0d3462b99fcc8dca5d0
https://doi.org/10.1172/jci25227

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Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells

Autor: Ke Li, Shailaja Hegde, Don M. Wojchowski, Vinit Karur, Madhu P. Menon

Publikováno v: Blood. 102:3147-3153

Signals provided by the erythropoieitin receptor (EpoR) are required for erythroid development beyond the erythroid colony-forming unit (CFU-e) stage and are propagated via the EpoR-tethered Janus kinase, JAK2. JAK2 functions, in part, to phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4572742571e28bad756873080367e07a
https://doi.org/10.1182/blood-2003-01-0078

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DYRK3 Activation, Engagement of Protein Kinase A/cAMP Response Element-binding Protein, and Modulation of Progenitor Cell Survival

Autor: Ke Li, Don M. Wojchowski, Vinit Karur, Shuqing Zhao

Publikováno v: Journal of Biological Chemistry. 277:47052-47060

DYRKs are a new family of dual-specificity tyrosine-regulated kinases with emerging roles in cell growth and development. Recently, we discovered that DYRK3 is expressed primarily in erythroid progenitor cells and modulates late erythropoiesis. We no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b5e1a2aae66389435495fc5400c045
https://doi.org/10.1074/jbc.m205374200

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A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis

Autor: Valter Agosti, Pradeep Sathyanarayana, Vinit Karur, Don M. Wojchowski, Peter Besmer

Objective KITL/KIT can elicit diverse sets of signals within lymphoid, myeloid, mast, and erythroid lineages, and exert distinct effects on growth, survival, migration, adhesion, and secretory responses. Presently, we have applied a PY-mutant allele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc209fddb612b841afd2ceaa3a038b7
https://europepmc.org/articles/PMC2701661/

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Lyn kinase promotes erythroblast expansion and late-stage development

Autor: Clifford A. Lowell, Peter Besmer, Vinit Karur, Valter Agosti, Don M. Wojchowski

Lyn kinase is known to modulate the formation and function of B cells, monocytes, and mast cells. However, Lyn-/- mice also develop erythrosplenomegaly, and cases for both negative and positive erythropoietic actions of Lyn recently have been outline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621f88148c74a69f008b1e9b221aebd0
https://europepmc.org/articles/PMC1895506/

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Erythropoietin-dependent erythropoiesis: New insights and questions

Autor: Estelle Houde, William Kapelle, Madhu P. Menon, Jing Fang, Pradeep Sathyanarayana, Oleg Bogachev, Vinit Karur, Don M. Wojchowski

Publikováno v: Blood cells, moleculesdiseases. 36(2)

Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their survival and for their quantitatively regulated transition to red blood cells. With regard to Epo signal transduction mechanisms, much has been learned from analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550d6e8d6b081cf3670480a006d40115
https://pubmed.ncbi.nlm.nih.gov/16524748

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