Physicochemical and Biological Evaluation of gem-Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery.

Autor: Melnykov KP; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01601, Kyїv, Ukraine., Liashuk OS; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01601, Kyїv, Ukraine., Holovach S; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyїv, 02660, Ukraine., Shatnia V; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; National Technical University of Ukraine 'Igor Sikorsky Kyiv Polytechnic Institute', Beresteiskyi Avenue 37, Kyїv, 03056, Ukraine., Horbenko A; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; V. I. Vernadsky Institute of General and Inorganic Chemistry, National Academy of Sciences of Ukraine, Akademik Palladin Street 32/34, Kyїv, 03142, Ukraine., Lesyk D; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01601, Kyїv, Ukraine.; Bienta/Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine., Melnyk V; Bienta/Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine., Skrypnik D; Bienta/Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine., Beshtynarska A; Bienta/Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine., Borysko P; Bienta/Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine., Viniichuk O; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01601, Kyїv, Ukraine., Grygorenko OO; Enamine Ltd., Winston Churchill Street 78, 02094, Kyїv, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01601, Kyїv, Ukraine.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Dec 11, pp. e202404390. Date of Electronic Publication: 2024 Dec 11.