Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vinesh J. Maharaj"'
Autor:
Phanankosi Moyo, Michael Ofori, Olusola S. Bodede, Madelien Wooding, Ndivhuwo Kevin Khorommbi, Lyndy J. McGaw, Cynthia A. Danquah, Vinesh J. Maharaj
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The emergence of drug-resistant Mycobacterium tuberculosis strains is a threat to global health necessitating the discovery of novel chemotherapeutic agents. Natural products drug discovery, which previously led to the discovery of rifamycin
Externí odkaz:
https://doaj.org/article/bde2bd6ea9874e079e0bcf94e60c848a
Autor:
Mach P. Achuoth, Cynthia M. Mudalungu, Brian O. Ochieng, Hosea O. Mokaya, Shadrack Kibet, Vinesh J. Maharaj, Sevgan Subramanian, Segenet Kelemu, Chrysantus M. Tanga
Publikováno v:
ACS Omega, Vol 9, Iss 7, Pp 8478-8489 (2024)
Externí odkaz:
https://doaj.org/article/900fa6b8bc0a49e8b2212b5044dc2f06
Autor:
Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Andrew W. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj
Publikováno v:
Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria. Urgent measures need to be taken to curb this impending challenge. The higher plant-derived sesqui
Externí odkaz:
https://doaj.org/article/aafcecec9a4c47c191e16778e16e60f1
Autor:
Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Warren A. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj
Publikováno v:
Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial
Externí odkaz:
https://doaj.org/article/019763d009274c179f8fac4d4c09cdfb
Autor:
Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 51-58 (2020)
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validatio
Externí odkaz:
https://doaj.org/article/642b4370fc534b02bced97c3b270352b
Autor:
Phanankosi Moyo, Phaladi Kunyane, Mamoalosi A. Selepe, Jacobus N. Eloff, Jandeli Niemand, Abraham I. Louw, Vinesh J. Maharaj, Lyn-Marie Birkholtz
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmission-blocking agents. W
Externí odkaz:
https://doaj.org/article/304eb84e92a24cfeb82cacf5cb45ff0e
Autor:
Cynthia Amaning Danquah, Prince Amankwah Baffour Minkah, Theresa A. Agana, Phanankosi Moyo, Michael Ofori, Peace Doe, Sibusiso Rali, Isaiah Osei Duah Junior, Kofi Bonsu Amankwah, Samuel Owusu Somuah, Isaac Newton Nugbemado, Vinesh J. Maharaj, Sanjib Bhakta, Simon Gibbons
Publikováno v:
Molecules, Vol 27, Iss 14, p 4475 (2022)
Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmaco
Externí odkaz:
https://doaj.org/article/58a9ea7254d54267a80782231a1a0b15
Autor:
Tinotenda Shoko, Vinesh J. Maharaj, Dashnie Naidoo, Malefa Tselanyane, Rudzani Nthambeleni, Eric Khorombi, Zeno Apostolides
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed as anti-aging ingred
Externí odkaz:
https://doaj.org/article/c2135caa2b56468287ff2b7665e6c9c9
Autor:
Phanankosi Moyo, Grace Mugumbate, Jacobus N. Eloff, Abraham I. Louw, Vinesh J. Maharaj, Lyn-Marié Birkholtz
Publikováno v:
Pharmaceuticals, Vol 13, Iss 9, p 251 (2020)
The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but
Externí odkaz:
https://doaj.org/article/486cca23267d4006a045d1da4b069d80
Autor:
Sephora Mutombo Mianda, Luke Invernizzi, Mariëtte E. van der Watt, Janette Reader, Phanankosi Moyo, Lyn-Marié Birkholtz, Vinesh J. Maharaj
Publikováno v:
Journal of ethnopharmacology. 297
Aloe marlothii A.Berger (Xanthorrhoeaceae) is indigenous to southern African countries where its aqueous preparations are used in traditional medicine to treat several ailments including hypertension, respiratory infections, venereal diseases, chest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167c4fc28212f6c6c5165d0ff4c32d26
https://pubmed.ncbi.nlm.nih.gov/35850311
https://pubmed.ncbi.nlm.nih.gov/35850311