Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vineet Vinay Kulkarni"'
Autor:
Vineet Vinay Kulkarni, Sandra Maday
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Macroautophagy (hereafter autophagy) and endocytic trafficking are key pathways in neuronal axons that regulate the composition and integrity of the axonal proteome. These pathways have similar trafficking itineraries; however, the extent of their cr
Externí odkaz:
https://doaj.org/article/d9ccaa5c36b2420f8936df9684a42599
Publikováno v:
J Neurosci
Autophagy and endocytic trafficking are two key pathways that regulate the composition and integrity of the neuronal proteome. Alterations in these pathways are sufficient to cause neurodevelopmental and neurodegenerative disorders. Thus, defining ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0221025435b879800887b1d757ed69c
https://doi.org/10.1523/jneurosci.1292-22.2022
https://doi.org/10.1523/jneurosci.1292-22.2022
Autophagy is a lysosomal degradative pathway important for neuronal development, function, and survival. But how autophagy in axons is regulated by neurotrophins to impact neuronal viability and function is poorly understood. Here, we investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9253e0737f68b71be81b34d4e6879628
https://doi.org/10.1101/2022.08.08.503181
https://doi.org/10.1101/2022.08.08.503181
Autophagy and endocytic trafficking are two key pathways that regulate the composition and integrity of the neuronal proteome. Alterations in these pathways are sufficient to cause neurodevelopmental and neurodegenerative disorders. Thus, defining ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::708f400d5c2db4bc0fdf6a5fd823a000
https://doi.org/10.1101/2022.07.01.498478
https://doi.org/10.1101/2022.07.01.498478
Autor:
David Kader Sidibe, Vineet Vinay Kulkarni, Audrey Dong, Jessica Brandt Herr, Maria Chalokh Vogel, Max Henry Stempel, Sandra Maday
Publikováno v:
Journal of Biological Chemistry. 298:102673
Autophagy is a lysosomal degradation pathway important for neuronal development, function, and survival. How autophagy in axons is regulated by neurotrophins to impact neuronal viability and function is poorly understood. Here, we use live-cell imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45e6b9088dbc20324c88b329e597b3
https://doi.org/10.1016/j.jbc.2022.102673
https://doi.org/10.1016/j.jbc.2022.102673
Autor:
Anip Anand, Audrey Dong, Jessica A. Chen, Aditi Kulkarni, Olivia Laxton, Sandra Maday, Vineet Vinay Kulkarni
Publikováno v:
Autophagy
Macroautophagy/autophagy is a key homeostatic process that targets cytoplasmic components to the lysosome for breakdown and recycling. Autophagy plays critical roles in glia and neurons that affect development, functionality, and viability of the ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a4845737cb434af2bf9d4c5f439224
https://doi.org/10.1080/15548627.2019.1703354
https://doi.org/10.1080/15548627.2019.1703354
Autor:
Sandra Maday, Maria C. Vogel, Jessica Brandt Herr, Anip Anand, Christina Miranda, Vineet Vinay Kulkarni
Publikováno v:
The Journal of Cell Biology
Guimas Almeida previews new work from the Maday laboratory demonstrating the regulation of autophagosome dynamics and function within dendrites by synaptic activity.
Regulation of autophagy in neurons remains unclear. In this issue, Kulkarni et
Regulation of autophagy in neurons remains unclear. In this issue, Kulkarni et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2131ffaab5f792b8200e20f228b0aa34
https://doi.org/10.1083/jcb.202002084
https://doi.org/10.1083/jcb.202002084
Autor:
Vineet Vinay Kulkarni, Sandra Maday
Publikováno v:
Developmental Neurobiology. 78:298-310
Autophagy is a lysosomal degradation pathway that is critical to maintaining neuronal homeostasis and viability. Autophagy sequesters damaged and aged cellular components from the intracellular environment, and shuttles these diverse macromolecules t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc014a0d38b094ebb14b42786da0fbec
https://doi.org/10.1002/dneu.22562
https://doi.org/10.1002/dneu.22562
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988723
Methods Mol Biol
Methods Mol Biol
Autophagy is an essential degradative pathway that maintains neuronal homeostasis and prevents axon degeneration. However, the mechanisms of autophagy in neurons are only beginning to be understood. To address this fundamental gap in knowledge, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add490aa28a6f80162cb8559fdf93d1c
https://doi.org/10.1007/978-1-4939-8873-0_16
https://doi.org/10.1007/978-1-4939-8873-0_16
Autor:
Vineet Vinay Kulkarni, Sandra Maday
Publikováno v:
The Journal of Cell Biology
Yap et al. show that in neurons, degradative lysosomes are clustered in proximal dendrites and in the soma, leading to a steep spatial gradient of degradative capacity along dendrites. Terminal degradation of dendritic cargos requires Rab7-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1347b312ebcaeb2e5836c00a8bec3484
https://pubmed.ncbi.nlm.nih.gov/29907658
https://pubmed.ncbi.nlm.nih.gov/29907658