Výsledky vyhledávání - "Vineela Chukkapalli"

Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells

Autor: Leo I. Gordon, Vineela Chukkapalli, Parameswaran Venugopal, Jeffrey A. Borgia, Reem Karmali

Publikováno v: Oncotarget

Metformin exerts direct anti-tumor effects by activating AMP-activated protein kinase (AMPK), a major sensor of cellular metabolism in cancer cells. This, in turn, inhibits pro-survival mTOR signaling. Metformin has also been shown to disrupt complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d36e0a37cc8c9c662eb49ef2e909bd
https://doi.org/10.18632/oncotarget.24989

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GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents

Autor: Leo I. Gordon, Jeffrey A. Borgia, Francis J. Giles, Andrew P. Mazar, Andrey Ugolkov, Reem Karmali, Vineela Chukkapalli

Publikováno v: Oncotarget

The complexities of GSK-3β function and interactions with PI3K/AKT/mTOR signaling, cell cycling, and apoptotic pathways are poorly understood in the context of lymphomagenesis and cancer therapeutics. In this study, we explored the anti-tumor effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e6d41685024dba8ccc31a92d6891ae
https://doi.org/10.18632/oncotarget.22414

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Impact of cachexia on outcomes in aggressive lymphomas

Autor: Ibtihaj Fughhi, Palmi Shah, Sunita Nathan, Sanjib Basu, Frank J. Penedo, Jeffrey A. Borgia, Taha Alrifai, Kelly Szymanski-Grant, Reem Karmali, Ronald Ng, Vineela Chukkapalli, Leo I. Gordon, Parameswaran Venugopal

Publikováno v: Annals of Hematology. 96:951-956

Cancer cachexia is defined as a state of involuntary weight loss, attributed to altered body composition with muscle mass loss and/or loss of adiposity. Identifying the association between cancer cachexia and outcomes may pave the way for novel agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d16896f95a64b2d3da3ba62d4f4f38
https://doi.org/10.1007/s00277-017-2958-1

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Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides

Autor: Vineela Chukkapalli, Meryl Thomas, Sean M. Kelly, Kristi L. Berger, Alexander Deiters, Glenn Randall

Publikováno v: Virology. 476:168-179

Combinations of direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) have the potential to revolutionize the HCV therapeutic regime. An integral component of DAA combination therapies is HCV NS5A inhibitors. It has previously been prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c1c0b9a56d82c311263c6a924681aa
https://doi.org/10.1016/j.virol.2014.12.018

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Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages

Autor: Vineela Chukkapalli, Akira Ono, Jingga Inlora, Sukhmani Bedi

The subcellular sites of HIV-1 assembly, determined by the localization of the structural protein Gag, vary in a cell-type-dependent manner. In T cells and transformed cell lines used as model systems, HIV-1 assembles at the plasma membrane (PM). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6345b2c35fe4a40986da23d3aa8679b4
https://europepmc.org/articles/PMC5021390/

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Impact of treatment variability on survival in immuno-competent and immuno-compromised patients with primary central nervous lymphoma

Autor: Reem Karmali, Leo I. Gordon, Chadi Nabhan, Sanjib Basu, Vineela Chukkapalli, Adam M. Petrich, Rimas V. Lukas, Parameswaran Venugopal, Jeffrey Raizer, David Peace

Publikováno v: British journal of haematology. 177(1)

Patients with primary central nervous system lymphoma (PCNSL) treated in the 'real-world' setting do not represent those treated on clinical trials and might not be treated similarly. We studied characteristics and variability in care for 113 newly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbab3f9afa74b8296eac6fe2a6b02dd
https://pubmed.ncbi.nlm.nih.gov/28211579

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Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites

Autor: Zhenlu Zhang, Vineela Chukkapalli, Jules Nchoutmboube, George A. Belov, Glenn Randall, Jiantao Zhang, Jianhui Li, Xiaofeng Wang

Publikováno v: Proceedings of the National Academy of Sciences. 113

All positive-strand RNA viruses reorganize host intracellular membranes to assemble their viral replication complexes (VRCs); however, how these viruses modulate host lipid metabolism to accommodate such membrane proliferation and rearrangements is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f278c73c1d5fed7974e13bb20b643f
https://doi.org/10.1073/pnas.1519730113

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Lipids at the interface of virus–host interactions

Autor: Nicholas S. Heaton, Vineela Chukkapalli, Glenn Randall

Publikováno v: Current Opinion in Microbiology. 15:512-518

Viruses physically and metabolically remodel the host cell to establish an optimal environment for their replication. Many of these processes involve the manipulation of lipid signaling, synthesis and metabolism. An emerging theme is that these lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9209dac6d7084a678df3edceeb9cde
https://doi.org/10.1016/j.mib.2012.05.013

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