Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vineel P. Reddy"'
Autor:
Belén Fernández Requena, Sajid Nadeem, Vineel P. Reddy, Vanessa Naidoo, Joel N. Glasgow, Adrie J. C. Steyn, Coral Barbas, Carolina Gonzalez-Riano
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Accurate lipid annotation is crucial for understanding the role of lipids in health and disease and identifying therapeutic targets. However, annotating the wide variety of lipid species in biological samples remains challenging in untargete
Externí odkaz:
https://doaj.org/article/d27ebf910c40418eb18bdda32715c24a
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by
Externí odkaz:
https://doaj.org/article/4e4ad46f3eb246c2ab7a16acbf265d77
Autor:
Ritesh R. Sevalkar, Joel N. Glasgow, Martín Pettinati, Marcelo A. Marti, Vineel P. Reddy, Swati Basu, Elmira Alipour, Daniel B. Kim-Shapiro, Dario A. Estrin, Jack R. Lancaster, Jr., Adrie J.C. Steyn
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102316- (2022)
Mycobacterium tuberculosis (Mtb) senses and responds to host-derived gasotransmitters NO and CO via heme-containing sensor kinases DosS and DosT and the response regulator DosR. Hydrogen sulfide (H2S) is an important signaling molecule in mammals, bu
Externí odkaz:
https://doaj.org/article/ad6d86dccdd64770afaed84592f13cac
Autor:
Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB diseas
Externí odkaz:
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
Autor:
Md. Aejazur Rahman, Joel N. Glasgow, Sajid Nadeem, Vineel P. Reddy, Ritesh R. Sevalkar, Jack R. Lancaster, Adrie J. C. Steyn
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an import
Externí odkaz:
https://doaj.org/article/5d986e84353d4a6bbff52ed2979f1dc6
Autor:
Vikram Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht, John H. Adamson, Vineel P. Reddy, Krishna C. Chinta, James H. Mazorodze, Joel N. Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 572-585 (2016)
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox bu
Externí odkaz:
https://doaj.org/article/e86030a4d9474eae8ff100fea63540c3
Autor:
Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1938-1952.e5 (2018)
Summary: Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the
Externí odkaz:
https://doaj.org/article/4c7da74431894b99aa2b05cd2ea1ba01
Autor:
Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis (Mtb). However, little is known about the mechanisms by which the host controls iron availability during infection. Since ferritin heavy chain (FtH) is a major int
Externí odkaz:
https://doaj.org/article/d79a2cc979e84fa6981d72ac6c9ff227
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kierveshan Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cdf01b8274064bd279cb8daf99a352
https://doi.org/10.1101/2022.09.11.507472
https://doi.org/10.1101/2022.09.11.507472
Autor:
Miguel Fernández-García, Vineel P. Reddy, Serge Rudaz, Coral Barbas, Adrie J. C. Steyn, Fernanda Rey-Stolle, Antonia García, Julien Boccard, Bridgette M. Cumming
Publikováno v:
Journal of Proteome Research, Vol. 19, No 5 (2020) pp. 2053-2070
Journal of Proteome Research
Journal of Proteome Research
The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry platforms to track altered lung metabolic changes associated with Mtb infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f691ea7415f0703a03a7370edabf473a
https://doi.org/10.1021/acs.jproteome.9b00868
https://doi.org/10.1021/acs.jproteome.9b00868