Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Vinee Purohit"'
Autor:
Ruihan Tang, Nandini Acharya, Ayshwarya Subramanian, Vinee Purohit, Marcin Tabaka, Yu Hou, Danyang He, Karen O. Dixon, Connor Lambden, Junrong Xia, Orit Rozenblatt-Rosen, Raymond A. Sobel, Chao Wang, Aviv Regev, Ana C. Anderson, Vijay K. Kuchroo
Publikováno v:
Sci Immunol
Dendritic cells (DCs) sense environmental cues and adopt either an immune-stimulatory or regulatory phenotype, thereby fine-tuning immune responses. Identifying endogenous regulators that determine DC function can thus inform the development of thera
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176820 (2017)
BACKGROUND:Mucin1 (MUC1), a glycoprotein associated with chemoresistance and an aggressive cancer phenotype, is aberrantly overexpressed in triple-negative breast cancer (TNBC). Recent studies suggest that MUC1 plays a role in modulating cancer cell
Externí odkaz:
https://doaj.org/article/8e6bfd10895c4376a889c7177b58ea9e
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179098 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0176820.].
Externí odkaz:
https://doaj.org/article/b7bc56ba9a444cf68c11b7b37e3229c3
Publikováno v:
Cancers, Vol 11, Iss 7, p 955 (2019)
Reactive oxygen species (ROS) are chemically active free radicals produced by partial reduction of oxygen that can activate discrete signaling pathways or disrupt redox homeostasis depending on their concentration. ROS interacts with biomolecules, in
Externí odkaz:
https://doaj.org/article/62748429084a4c2e9bc793aa9376198b
Publikováno v:
Cellularmolecular immunology. 19(3)
Technical advances at the interface of biology and computation, such as single-cell RNA-sequencing (scRNA-seq), reveal new layers of complexity in cellular systems. An emerging area of investigation using the systems biology approach is the study of
Autor:
Vinee Purohit, Sofia D. Merajver, David B. Lombard, Laura E. Goo, Ilya Kovalenko, Joel A. Yates, Samuel A. Kerk, Andrew C. Little, Hanna Sungok Hong, Costas A. Lyssiotis
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Metabolic flux technology with the Seahorse bioanalyzer has emerged as a standard technique in cellular metabolism studies, allowing for simultaneous kinetic measurements of respiration and glycolysis. Methods to extend the utility and versatility of
Autor:
Nina V Chaika, Fang Yu, Vinee Purohit, Kamiya Mehla, Audrey J Lazenby, Dominick DiMaio, Judy M Anderson, Jen Jen Yeh, Keith R Johnson, Michael A Hollingsworth, Pankaj K Singh
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32996 (2012)
Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a five-year survival rate of 6%. It is characterized by extremely aggressive tumor growth rate and high incidence of metastasis. One of the most common a
Externí odkaz:
https://doaj.org/article/3d07d5aecc804eda98e4f8aa643653bf
Autor:
Michael A. Badgley, Kenneth P. Olive, Zachary P. Tolstyka, Steve A. Sastra, Brent R. Stockwell, Jonathan Kapillian, Geoffrey M. Wahl, Ho-Joon Lee, Uri Manor, E. Scott Seeley, Irina Sagalovskiy, Daniel M. Kremer, Leonardo R. Andrade, Everett Stone, Amanda R. Decker, Kathleen E. DelGiorno, George Georgiou, H. Carlo Maurer, Li Zhang, Alice Ma, Tong Liu, Candice Lamb, Christina E. M. Firl, Carmine F. Palermo, Costas A. Lyssiotis, Wei Gu, Alina Iuga, Tal Hirschhorn, Vinee Purohit, Peter Sajjakulnukit
Pancreatic ductal adenocarcinoma (PDA) is the third-leading cause of cancer mortality in the US and is highly resistant to classical, targeted, and immune therapies. We show that human PDA cells are dependent on the provision of exogenous cystine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3979aae84b9a417410ca41872a3a235
Autor:
Vinee Purohit, Sofia D. Merajver, Hanna S. Hong, Joel A. Yates, Samuel A. Kerk, Andrew C. Little, Ilya Kovalenko, David B. Lombard, Costas A. Lyssiotis, Laura E. Goo
SUMMARYMetabolic flux technology with the Seahorse bioanalyzer has emerged as a standard technique in cellular metabolism studies, allowing for simultaneous kinetic measurements of respiration and glycolysis. Methods to extend the utility and versati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b344fbac2372d6095616eeb39292dc
https://doi.org/10.1101/758110
https://doi.org/10.1101/758110
Autor:
H. Carlo Maurer, Irina Sagalovskiy, Daniel M. Kremer, Peter Sajjakulnukit, Geoffrey M. Wahl, Everett Stone, Steve A. Sastra, Uri Manor, Alina Iuga, Ho-Joon Lee, Christina E. M. Firl, Brent R. Stockwell, George Georgiou, Costas A. Lyssiotis, Kenneth P. Olive, Wei Gu, Li Zhang, Tal Hirschhorn, E. Scott Seeley, Alice Ma, Amanda R. Decker, Kathleen E. DelGiorno, Jonathan Kapilian, Vinee Purohit, Carmine F. Palermo, Tong Liu, Zachary P. Tolstyka, Leonardo R. Andrade, Candice Lamb, Michael A. Badgley
Publikováno v:
Science
Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is tri