Výsledky vyhledávání

Akademický článek

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo .

Autor: Ye T; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA., Alamgir A; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA., Robertus CM; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853 USA., Colina D; Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853 USA., Monticello C; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853 USA., Donahue TC; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA., Hong L; Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA., Vincoff S; Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA., Goel S; Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA., Fekkes P; UbiquiTx, 750 Main Street, Cambridge, MA 02139 USA., Camargo LM; UbiquiTx, 750 Main Street, Cambridge, MA 02139 USA., Lam K; Genevant Sciences Corporation, 887 Great Northern Way, Vancouver, BC, V5T 4T5 Canada., Heyes J; Genevant Sciences Corporation, 887 Great Northern Way, Vancouver, BC, V5T 4T5 Canada., Putnam D; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA.; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853 USA., Alabi CA; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA.; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853 USA., Chatterjee P; Department of Biomedical Engineering, Duke University, Durham, NC 27708 USA.; Department of Computer Science, Duke University, Durham, NC 27708 USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708 USA., DeLisa MP; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA.; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853 USA.; Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853 USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY 14853 USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 11. Date of Electronic Publication: 2024 Nov 11.

Zobrazit plný text záznamu

Akademický článek

PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling.

Autor: Chen T; Department of Biomedical Engineering, Duke University., Dumas M; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University.; Department of Microbiology, College of Agriculture and Life Sciences, Cornell University., Watson R; Department of Biomedical Engineering, Duke University., Vincoff S; Department of Biomedical Engineering, Duke University., Peng C; Department of Biochemistry and Biomedical Sciences, McMaster University., Zhao L; Department of Biomedical Engineering, Duke University., Hong L; Department of Biomedical Engineering, Duke University., Pertsemlidis S; Department of Biomedical Engineering, Duke University., Shaepers-Cheu M; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University., Wang TZ; Department of Biomedical Engineering, Duke University., Srijay D; Department of Biomedical Engineering, Duke University., Monticello C; Department of Biochemistry and Biomedical Sciences, McMaster University., Vure P; Department of Biomedical Engineering, Duke University., Pulugurta R; Department of Biomedical Engineering, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Goel S; Department of Biomedical Engineering, Duke University., DeLisa MP; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University., Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.

Publikováno v: ArXiv [ArXiv] 2024 Aug 11. Date of Electronic Publication: 2024 Aug 11.

Zobrazit plný text záznamu

Akademický článek

Programmable Protein Stabilization with Language Model-Derived Peptide Guides.

Autor: Hong L; Department of Biomedical Engineering, Duke University., Ye T; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Wang TZ; Department of Biomedical Engineering, Duke University., Srijay D; Department of Biomedical Engineering, Duke University., Zhao L; Department of Biomedical Engineering, Duke University., Watson R; Department of Biomedical Engineering, Duke University., Vincoff S; Department of Biomedical Engineering, Duke University., Chen T; Department of Biomedical Engineering, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Goel S; Department of Biomedical Engineering, Duke University., DeLisa MP; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.

Publikováno v: Research square [Res Sq] 2024 Jul 26. Date of Electronic Publication: 2024 Jul 26.

Zobrazit plný text záznamu

Akademický článek

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling.

Autor: Bhat S; Department of Biomedical Engineering, Duke University., Palepu K; Department of Biomedical Engineering, Duke University., Hong L; Department of Biomedical Engineering, Duke University., Mao J; Department of Cell Biology, Duke University., Ye T; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Iyer R; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Zhao L; Department of Biomedical Engineering, Duke University., Chen T; Department of Biomedical Engineering, Duke University., Vincoff S; Department of Biomedical Engineering, Duke University., Watson R; Department of Biomedical Engineering, Duke University., Wang T; Department of Biomedical Engineering, Duke University., Srijay D; Department of Biomedical Engineering, Duke University., Kavirayuni VS; Department of Biomedical Engineering, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Goel S; Department of Biomedical Engineering, Duke University., Vure P; Department of Biomedical Engineering, Duke University., Desphande AJ; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Soderling SH; Department of Cell Biology, Duke University., DeLisa MP; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.

Zobrazit plný text záznamu

Akademický článek

FusOn-pLM: A Fusion Oncoprotein-Specific Language Model via Focused Probabilistic Masking.

Autor: Vincoff S; Department of Biomedical Engineering, Duke University., Goel S; Department of Computer Science, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Pulugurta R; Department of Biomedical Engineering, Duke University., Vure P; Department of Biomedical Engineering, Duke University., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 04. Date of Electronic Publication: 2024 Jun 04.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání