Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vincenzo Prato"'
Autor:
Timo A. Nees, Na Wang, Pavel Adamek, Nadja Zeitzschel, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity
Externí odkaz:
https://doaj.org/article/ad36199c53bf4668bb1d766ff2c256d7
Autor:
Robin Jonas, Vincenzo Prato, Stefan G. Lechner, Gerbrand Groen, Otilia Obreja, Fiona Werland, Roman Rukwied, Andreas Klusch, Marlen Petersen, Richard W. Carr, Martin Schmelz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX
Externí odkaz:
https://doaj.org/article/940d087a68b74902b0e07b9c69eb24d5
Autor:
Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3102-3115 (2017)
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described
Externí odkaz:
https://doaj.org/article/de82496017424d9f95bdaa393f2d5efc
Autor:
Timo A. Nees, Na Wang, Pavel Adamek, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Nadja Zeitzschel, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
SummarySilent nociceptors are sensory afferents that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli during inflammation. Using RNA-sequencing and quantitative RT-PCR we demonstrate that inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89460af4310a8b91006c729c3bee9b82
https://doi.org/10.1101/2022.04.07.486730
https://doi.org/10.1101/2022.04.07.486730
Autor:
Paul A. Heppenstall, Irina Schaefer, Vincenzo Prato, Stefan G. Lechner, Francisco J. Taberner, Katrin Schrenk-Siemens
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Aristotle’s five senses—sight, smell, taste, hearing, and touch—are crucial for the perception of and interaction with the environment. While the molecular machineries that detect visual, olfactory, gustatory, and auditory stimuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7732308fa8ea787069af277dad44a2ae
https://doi.org/10.1073/pnas.1905985116
https://doi.org/10.1073/pnas.1905985116
Autor:
Stefan G. Lechner, Hagen Wende, Vijayan Gangadharan, Vincenzo Prato, Carmen Birchmeier, Paul A. Heppenstall, Francisco J. Taberner, Louise Gorham, Rahul Dhandapani, Alice Arcourt
Publikováno v:
Neuron. 93:179-193
Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4b572cd3570520a489abd6684c09fd
https://doi.org/10.1016/j.neuron.2016.11.027
https://doi.org/10.1016/j.neuron.2016.11.027
Publikováno v:
Molecular Pain
Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors. It was shown that nerve growth factor increases th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ea4cf37394737223fc684e2bc937a9
http://europepmc.org/articles/PMC6856966
http://europepmc.org/articles/PMC6856966
Autor:
Bassim Tazir, Francisco J. Taberner, Leoni Hammer, Paul A. Heppenstall, Paulina Schad, Ewan St. John Smith, Stefan G. Lechner, Alice Arcourt, Gerard Callejo, Vincenzo Prato, James R.F. Hockley
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3102-3115 (2017)
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bba8bc9d50ec863c60822aa89e9af4
Autor:
Stefan G. Lechner, Jochen Utikal, Kun Song, Vincenzo Prato, Charlotte Rostock, Gary R. Lewin, Hagen Wende, Alexander Loewer, Jan Siemens, Katrin Schrenk-Siemens
Publikováno v:
Nature Neuroscience. 18:10-16
Human sensory neurons are inaccessible for functional examination, and thus little is known about the mechanisms mediating touch sensation in humans. Here we demonstrate that the mechanosensitivity of human embryonic stem (hES) cell-derived touch rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b48a53da401ac10169b7fc7e6b930c
https://doi.org/10.1038/nn.3894
https://doi.org/10.1038/nn.3894