Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Vincenzo Panagia"'
Publikováno v:
Molecular and Cellular Biochemistry. 283:93-100
In this study, we examined changes in the biochemical and inotropic events of the alpha(1)-adrenoceptor signaling pathway in hypothyroid rat hearts. Hypothyroidism was induced by treating experimental animals with 0.05% 6-n-propyl-2-thiouracil (PTU)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c254ce9d06c649ff9a54f04c8d3275d
https://doi.org/10.1007/s11010-006-2348-9
https://doi.org/10.1007/s11010-006-2348-9
Autor:
J. Alejandro Austria, Nidhi Sahi, Grant N. Pierce, Thane G. Maddaford, Vincenzo Panagia, Paramjit S. Tappia, Cecilia Hurtado, Elena Dibrov
Publikováno v:
Biochemical and Biophysical Research Communications. 316:280-289
The effects of exogenous phosphatidic acid (PA) on Ca2+ transients and contractile activity were studied in cardiomyocytes isolated from chronic streptozotocin-induced diabetic rats. In control cells, 25 μM PA induced a significant increase in activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8324d43830fd5607ffe8dbbbdecb4672
https://doi.org/10.1016/j.bbrc.2004.02.045
https://doi.org/10.1016/j.bbrc.2004.02.045
Autor:
Chang-Hua Yu, Vincenzo Panagia, Naranjan S. Dhalla, Paramjit S. Tappia, Song-Yan Liu, Nobuakira Takeda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1584:65-72
Phospholipase D 2 (PLD2) is the major PLD isozyme associated with the cardiac sarcolemmal (SL) membrane. Hydrolysis of SL phosphatidylcholine (PC) by PLD2 produces phosphatidic acid (PA), which is then converted to 1,2 diacylglycerol (DAG) by the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5159441b3cd090f75755ee19494f9e
https://doi.org/10.1016/s1388-1981(02)00270-6
https://doi.org/10.1016/s1388-1981(02)00270-6
Autor:
Paramjit S. Tappia, Naranjan S. Dhalla, Paolo Di Nardo, Chang-Hua Yu, Vincenzo Panagia, Ajai K. Pasricha
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:431-440
The cardiac sarcolemmal membrane cis -unsaturated fatty acid-sensitive phospholipase D hydrolyzes phosphatidylcholine to form phosphatidic acid. The functional significance of phosphatidic acid is indicated by its ability to increase [Ca 2+ ] i and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06af5aec85ebf46b7ec11bcf8bc4c79b
https://doi.org/10.1006/jmcc.2000.1315
https://doi.org/10.1006/jmcc.2000.1315
Autor:
Attila Ziegelhoffer, Vincenzo Panagia, Nidhi Sahi, Nasrin Mesaeli, Naranjan S. Dhalla, Paramjit S. Tappia
Publikováno v:
Cardiovascular Research. 49:118-126
Objective: Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is not only a precursor to inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and sn -1,2 diacylglycerol, but also essential for the function of several membrane proteins. The aim of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519821ade6312dee2c0f7e122dcbd384
https://doi.org/10.1016/s0008-6363(00)00209-1
https://doi.org/10.1016/s0008-6363(00)00209-1
Autor:
Paramjit S. Tappia, Mohinder S. Nijjar, Kenichi Kawabata, Naranjan S. Dhalla, Kanhaiya R. Shah, Vincenzo Panagia, Kenji Okumura
Publikováno v:
Molecular and Cellular Biochemistry. 221:89-98
Evidence indicates that, in addition to the L-type Ca2+ channel blockade, Ca2+-antagonists target other functions including the Ca2+-pumps. This study was conducted to test the possibility that the reported inhibition of heart sarcolemmal (SL) and sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748b1d1346e81ff46ff97c022eb5986d
https://doi.org/10.1023/a:1010905221770
https://doi.org/10.1023/a:1010905221770
Publikováno v:
Europe PubMed Central
Cardiac sarcolemmal Na+/H+exchange is critical for the regulation of intracellular pH, and its activity contributes to ischemia-reperfusion injury. It has been suggested that the membrane phospholipid environment does not modulate Na+/H+exchange. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4a2643722f0dc7cb33d8a120da409d
https://doi.org/10.1152/ajpheart.2000.279.3.h1179
https://doi.org/10.1152/ajpheart.2000.279.3.h1179
Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 3:239-245
Background: Some β-adrenoceptor antagonists exert a negative inotropic action by affect ing Ca2+ fluxes in the myocardial cell as a consequence of their interaction with sarcolem mal and sarcoplasmic reticular membranes. This action may be caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6911c1c78b5e7161a58db88464fc72d
https://doi.org/10.1177/107424849800300307
https://doi.org/10.1177/107424849800300307