The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Autor: David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose

Publikováno v: Cell Reports, Vol 20, Iss 10, Pp 2313-2327 (2017)

Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters in vertebrates and how th

Externí odkaz: https://doaj.org/article/9b58edca6b994f178ed582935538118f

Vector Copy Distribution at a Single-Cell Level Enhances Analytical Characterization of Gene-Modified Cell Therapies

Autor: Vincenzo Di Cerbo, Enas Hassan, Damian Marshall, Beata Surmacz-Cordle, Marta Bagnati, Emily Jane Harvey, Ilaria Santeramo

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 944-956 (2020)
Molecular Therapy. Methods & Clinical Development

The ability to deliver transgenes into the human genome using viral vectors is a major enabler of the gene-modified cell therapy field. However, the control of viral transduction is difficult and can lead to product heterogeneity, impacting efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeb7f6aa7c3f03851e8b3b32ead8b85
http://www.sciencedirect.com/science/article/pii/S2329050120300760

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Autor: Jo Vandesompele, Peter Nürnberg, Shantanu Banerji, Lukas C. Heukamp, Stefanie Heynck, Matthias Fischer, Daniel Rauh, Sylvie Lantuejoul, Ingelore Baessmann, Holger Moch, Matthew Meyerson, Reinhard Büttner, Kwon-Sik Park, Ines Wilkening, Steinar Solberg, Stefan A. Haas, Egber Smit, Dennis Plenker, Zoe Wainer, Prudence A. Russell, Ilona Dahmen, William Pao, Erik Thunnissen, C. Ligorio, Bram De Wilde, Paul K. Brindle, Diana Böhm, Vito Michele Fazio, Vincenzo Di Cerbo, Benjamin Solomon, Stefania Damiani, Walburga Engel-Riedel, Erich Stoelben, Corinna Ludwig, Hannie Sietsma, Daniëlle A M Heideman, Jürgen Wolf, Thomas Muley, Elisabeth Brambilla, Ruping Sun, Wim Timens, Jay Shendure, Laura Pasqualucci, Kristian Cibulskis, Julien Sage, Gavin M. Wright, Mirjam Koker, Pierre Validire, Danila Seidel, Johannes M. Heuckmann, Harry J.M. Groen, Christian Becker, Philippe Lorimier, Peter J.F. Snijders, Sven Perner, Michael Brockmann, Xin Lu, Franziska Gabler, Scott L. Carter, Marius Lund-Iversen, Lucia Anna Muscarella, Jörg Sänger, Benjamin Besse, Hans Ulrich Schildhaus, Frauke Leenders, John K. Field, Odd Terje Brustugun, Christian Brambilla, Philipp A. Schnabel, Sascha Ansén, Christian Grütter, Michael Hallek, Gad Getz, Yuan Chen, Roopika Menon, Roman K. Thomas, Joachim H. Clement, Janine Altmüller, Martin L. Sos, Hans Hoffmann, Peter M. Schneider, Julie George, Christian Müller, Iver Petersen, Federico Cappuzzo, Lawryn H. Kasper, Robert Schneider, Martin Peifer, Lynnette Fernandez-Cuesta, Jean-Charles Soria, Alex Soltermann, Thomas Zander, Walter Weder

Publikováno v: Nature Genetics
Nature Genetics, 44(10), 1104-1110. Nature Publishing Group
Peifer, M, Fernandez-Cuesta, L, Sos, M L, George, J, Seidel, D, Kasper, L H, Plenker, D, Leenders, F, Sun, R, Zander, T, Menon, R, Koker, M, Dahmen, I, Muller, C, Di Cerbo, V, Schildhaus, H U, Altmuller, J, Baessmann, I, Becker, C, de Wilde, B, Vandesompele, J, Bohm, D, Ansen, S, Gabler, F, Wilkening, I, Heynck, S, Heuckmann, J M, Lu, X, Carter, S L, Cibulskis, K, Banerji, S, Getz, G, Park, K S, Rauh, D, Grutter, C, Fischer, M, Pasqualucci, L, Wright, G, Wainer, Z, Russell, P, Petersen, I, Chen, Y, Stoelben, E, Ludwig, C, Schnabel, P, Hoffmann, H, Muley, T, Brockmann, M, Engel-Riedel, W, Muscarella, L A, Fazio, V M, Groen, H, Timens, W, Sietsma, H, Thunnissen, F B J M, Smit, E F, Heideman, D A M, Snijders, P J F, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J, Solberg, S, Brustugun, O T, Lund-Iversen, M, Sanger, J, Clement, J H, Soltermann, A, Moch, H, Weder, W, Solomon, B, Soria, J C, Validire, P, Besse, B, Brambilla, E, Brambilla, C, Lantuejoul, S, Lorimier, P, Schneider, P M, Hallek, M, Pao, W, Meyerson, M, Sage, J, Shendure, J, Schneider, R, Buttner, R, Wolf, J, Nurnberg, P, Perner, S, Heukamp, L C, Brindle, P K, de Haas, S & Thomas, R K 2012, ' Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer ', Nature Genetics, vol. 44, no. 10, pp. 1104-1110 . https://doi.org/10.1038/ng.2396
Nature Genetics, 44(10), 1104-+. Nature Publishing Group
Nature Genetics; Vol 44

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis(1-3). We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 +/- 1 protein-changing mutations per million bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0d1e6a51b124adf71538e70086efc8
https://doi.org/10.1038/ng.2396

Author response: Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

Autor: Leslie Hoerner, Philipp Tropberger, Emilie Montellier, Salim Kacem, Eleni Kallis, Fabio Mohn, Tom Owen-Hughes, Monika Holzner, Saadi Khochbin, Robert Feil, Sylvain Daujat, Angelika Feldmann, Daniel P. Ryan, Andrew J. Bannister, Jens Michaelis, Gerhard Mittler, Robert Schneider, Florian Richter, Vincenzo Di Cerbo, Dirk Schuebeler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::219fe7f015664b5b588f2b8a1383b836
https://doi.org/10.7554/elife.01632.028