Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Vincenzo Alterio"'
Autor:
Annachiara Sarnella, Ylenia Ferrara, Luigi Auletta, Sandra Albanese, Laura Cerchia, Vincenzo Alterio, Giuseppina De Simone, Claudiu T. Supuran, Antonella Zannetti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Hypoxic tumor microenvironment (TME) contributes to the onset of many aspects of the cancer biology associated to the resistance to conventional therapies. Hypoxia is a common characteristic and negative prognostic factor in the h
Externí odkaz:
https://doaj.org/article/c3af596b9c224abf8f2aa0ccc88b73f4
Autor:
Vincenzo Alterio, Emma Langella, Martina Buonanno, Davide Esposito, Alessio Nocentini, Emanuela Berrino, Silvia Bua, Maurizio Polentarutti, Claudiu T. Supuran, Simona Maria Monti, Giuseppina De Simone
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3427-3436 (2021)
CDCA1 is a very peculiar member of the Carbonic Anhydrase (CA) family. It has been the first enzyme to show an efficient utilization of Cd(II) ions in Nature and a unique adaptation capability to live on the surface ocean. Indeed, in this environment
Externí odkaz:
https://doaj.org/article/c1292d4aad664a14a0666800843060b6
Autor:
Emma Langella, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone, Vincenzo Alterio
Publikováno v:
Biology, Vol 12, Iss 2, p 281 (2023)
Aliphatic sulfonamides are an interesting class of carbonic anhydrase inhibitors (CAIs) proven to be effective for several carbonic anhydrase (CA) isoforms involved in pathologic states. Here we report the crystallographic structures of hCA II in com
Externí odkaz:
https://doaj.org/article/2b643e7e8bfd430c9ff810c7bbb70555
Autor:
Emma Langella, Anna Di Fiore, Vincenzo Alterio, Simona Maria Monti, Giuseppina De Simone, Katia D’Ambrosio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 12045 (2022)
Carbonic anhydrases (CAs) are ubiquitous enzymes that catalyze the reversible carbon dioxide hydration reaction. Among the eight different CA classes existing in nature, the α-class is the largest one being present in animals, bacteria, protozoa, fu
Externí odkaz:
https://doaj.org/article/58af4ea79dbb4331be0929e3bc2f02ca
Autor:
Emma Langella, Vincenzo Alterio, Katia D’Ambrosio, Roberta Cadoni, Jean-Yves Winum, Claudiu T. Supuran, Simona Maria Monti, Giuseppina De Simone, Anna Di Fiore
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1498-1505 (2019)
Recent studies identified the benzoxaborole moiety as a new zinc-binding group able to interact with carbonic anhydrase (CA) active site. Here, we report a structural analysis of benzoxaboroles containing urea/thiourea groups, showing that these mole
Externí odkaz:
https://doaj.org/article/83251cf196c344de85ae41f9443a013d
Autor:
Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 151-157 (2018)
Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form w
Externí odkaz:
https://doaj.org/article/7148bc14a2c6448aa04ccd67d65d3325
Autor:
Giuseppina De Simone, Emma Langella, Davide Esposito, Claudiu T. Supuran, Simona Maria Monti, Jean-Yves Winum, Vincenzo Alterio
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1002-1011 (2017)
Sulphamate and sulphamide derivatives have been largely investigated as carbonic anhydrase inhibitors (CAIs) by means of different experimental techniques. However, the structural determinants responsible for their different binding mode to the enzym
Externí odkaz:
https://doaj.org/article/1138df708b884b22bb3b52f875580d45
Autor:
Annachiara Sarnella, Giuliana D’Avino, Billy Samuel Hill, Vincenzo Alterio, Jean-Yves Winum, Claudiu T. Supuran, Giuseppina De Simone, Antonella Zannetti
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8405 (2020)
Cell plasticity is the ability that cells have to modify their phenotype, adapting to the environment. Cancer progression is under the strict control of the the tumor microenvironment that strongly determines its success by regulating the behavioral
Externí odkaz:
https://doaj.org/article/ab0a9ea38fad4d1fbc57a844ccd609b5
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15456-15480 (2015)
Carbonic anhydrases are ubiquitous metallo-enzymes which catalyze the reversible hydration of carbon dioxide in bicarbonate ions and protons. Recent years have seen an increasing interest in the utilization of these enzymes in CO2 capture and storage
Externí odkaz:
https://doaj.org/article/2a20c56560de4c9d94a7fcea359b0853
Publikováno v:
Marine Drugs, Vol 13, Iss 4, Pp 1688-1697 (2015)
The Carbon Concentration Mechanism (CCM) allows phytoplakton species to accumulate the dissolved inorganic carbon (DIC) necessary for an efficient photosynthesis even under carbon dioxide limitation. In this mechanism of primary importance for diatom
Externí odkaz:
https://doaj.org/article/79580a75d48c4b94b2b5ffd3416e8436