Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Vincenzo Cirulli"'
Autor:
Jason Fan, Wen Du, Ja Young Kim-Muller, Jinsook Son, Taiyi Kuo, Delfina Larrea, Christian Garcia, Takumi Kitamoto, Michael J. Kraakman, Edward Owusu-Ansah, Vincenzo Cirulli, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 97-111 (2020)
Objective: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking
Externí odkaz:
https://doaj.org/article/375623377933483ab07e7a75a8f0e1a3
Autor:
Wendy Yang, Paul D. Lampe, Patricia Kensel-Hammes, Jennifer Hesson, Carol B. Ware, Laura Crisa, Vincenzo Cirulli
Publikováno v:
iScience, Vol 19, Iss , Pp 450-460 (2019)
Summary: Efficient stem cell differentiation into pancreatic islet cells is of critical importance for the development of cell replacement therapies for diabetes. Here, we identify the expression pattern of connexin 43 (Cx43), a gap junction (GJ) cha
Externí odkaz:
https://doaj.org/article/e031a3a500ff4f00a1541a18ae2cedc1
Autor:
Antonio J. Jimenez-Caliani, Rudolf Pillich, Wendy Yang, Giuseppe R. Diaferia, Paolo Meda, Laura Crisa, Vincenzo Cirulli
Publikováno v:
Cell Reports, Vol 20, Iss 6, Pp 1295-1306 (2017)
The development and function of epithelia depend on the establishment and maintenance of cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the transduction of biochemical signals regulating cell proliferation, di
Externí odkaz:
https://doaj.org/article/eab1946e9b9044a7b3ed2efe4569912f
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 169-179 (2016)
During pancreas development, epithelial buds undergo branching morphogenesis to form an exocrine and endocrine gland. Proper morphogenesis is necessary for correct lineage allocation of pancreatic progenitors; however, the cellular events underlying
Externí odkaz:
https://doaj.org/article/ddc2d14230e14354ae3b330329225551
Autor:
Laura Crisa, Vincenzo Cirulli
Publikováno v:
Cell reports. 41(7)
In their recent Cell Reports paper, Chang and colleagues report on a successful strategy to achieve durable mixed hematopoietic chimerism that promotes the engraftment and long-term function of pancreatic islet allotransplants in fully immunocompeten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cff7e8261a413ffbb39a65af324e798
https://pubmed.ncbi.nlm.nih.gov/36384104
https://pubmed.ncbi.nlm.nih.gov/36384104
Autor:
Hung Pham, Chiara Birtolo, Chintan Chheda, Wendy Yang, Maria Rodriguez, Sandy Liu, Gabriele Gugliotta, Michael Lewis, Vincenzo Cirulli, Stephen Pandol, Andrzej Ptasznik
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ. The treatment options are inadequate and reflect the fact that signalin
Externí odkaz:
https://doaj.org/article/8a7230bd9955468b915e3a83c65745c7
Autor:
Kristin Mussar, Andrew Tucker, Linsey McLennan, Addie Gearhart, Antonio J Jimenez-Caliani, Vincenzo Cirulli, Laura Crisa
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89492 (2014)
Macrophages populate the mesenchymal compartment of all organs during embryogenesis and have been shown to support tissue organogenesis and regeneration by regulating remodeling of the extracellular microenvironment. Whether this mesenchymal componen
Externí odkaz:
https://doaj.org/article/a8d06ce5f7c04b53a326167cc4c51f16
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79458 (2013)
SEL1L, a component of the endoplasmic reticulum associated degradation (ERAD) pathway, has been reported to regulate the (i) differentiation of the pancreatic endocrine and exocrine tissue during the second transition of mouse embryonic development,
Externí odkaz:
https://doaj.org/article/93326e4812c142f3befeb8a58717c4fd
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/92ae88179e024421940d26b7486793ef
Autor:
Gabriele Alfarano, Paola Nicoli, Elena Prosperini, Vincenzo Cirulli, Sara Polletti, Marta Milan, Chiara Balestrieri, Giuseppe R. Diaferia, Paola Spaggiari, Alessandro Zerbi, Gioacchino Natoli
Publikováno v:
Developmental cell. 55(4)
Summary Many tumors of endodermal origin are composed of highly secretory cancer cells that must adapt endoplasmic reticulum (ER) activity to enable proper folding of secreted proteins and prevent ER stress. We found that pancreatic ductal adenocarci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f473cff9ee8af39065eb97ef101f4680
https://pubmed.ncbi.nlm.nih.gov/32997974
https://pubmed.ncbi.nlm.nih.gov/32997974