Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Vincenzo, Carnevale"'
Autor:
Alexander G. Lucaci, William E. Brew, Jason Lamanna, Avery Selberg, Vincenzo Carnevale, Anna R. Moore, Sergei L. Kosakovsky Pond
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Rad And Gem-Like GTP-Binding Protein 2 (Rem2), a member of the RGK family of Ras-like GTPases, is implicated in Huntington’s disease and Long QT Syndrome and is highly expressed in the brain and endocrine cells. We examine the evolutionary history
Externí odkaz:
https://doaj.org/article/1ddb041bf17341888a1691d77053b84d
Autor:
Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A. Matreyek, Douglas M. Fowler, Vincenzo Carnevale, Chad L. Myers, Daniel Schmidt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here, the authors perform a large-scale, high-throughput biochemical assay to determine the compatibility of over 300,000 domain recombination variants of the inward rectifier K+ channel Kir2.1. They derive rules for designing domain insertion varian
Externí odkaz:
https://doaj.org/article/446c0c0118e64afe931272b243499af9
Autor:
Francisco McGee, Sandro Hauri, Quentin Novinger, Slobodan Vucetic, Ronald M. Levy, Vincenzo Carnevale, Allan Haldane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Generative models have become increasingly popular in protein design, yet rigorous metrics that allow the comparison of these models are lacking. Here, the authors propose a set of such metrics and use them to compare three popular models.
Externí odkaz:
https://doaj.org/article/83efc157c65a47839c682e567e6f8c92
Publikováno v:
Cells, Vol 12, Iss 13, p 1680 (2023)
Until recently, Deltex (DTX) proteins have been considered putative E3 ligases, based on the presence of an E3 RING domain in their protein coding sequence. The human DTX family includes DTX1, DTX2, DTX3, DTX3L and DTX4. Despite the fact that our kno
Externí odkaz:
https://doaj.org/article/29860b8057544dc58d3d36c337a7dbb4
Autor:
Deny Cabezas-Bratesco, Francisco A Mcgee, Charlotte K Colenso, Kattina Zavala, Daniele Granata, Vincenzo Carnevale, Juan C Opazo, Sebastian E Brauchi
Publikováno v:
eLife, Vol 11 (2022)
Transient receptor potential (TRP) proteins are a large family of cation-selective channels, surpassed in variety only by voltage-gated potassium channels. Detailed molecular mechanisms governing how membrane voltage, ligand binding, or temperature c
Externí odkaz:
https://doaj.org/article/b300337cbf56419f86ffbabb4e515e03
Autor:
Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs
Externí odkaz:
https://doaj.org/article/093c0d5069da4980a49ad192ca552eb0
Publikováno v:
The Journal of Physical Chemistry B. 127:3682-3689
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3801b4724638453c01b228c6a994cb2b
https://doi.org/10.1021/acs.jpcb.3c00805
https://doi.org/10.1021/acs.jpcb.3c00805
Publikováno v:
Journal of Chemical Information and Modeling. 63:2419-2426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e14fc7a0bed65a947e074f61371c43
https://doi.org/10.1021/acs.jcim.3c00049
https://doi.org/10.1021/acs.jcim.3c00049
Autor:
Elisa Cairoli, Giorgia Grassi, Agostino Gaudio, Andrea Palermo, Fabio Vescini, Alberto Falchetti, Daniela Merlotti, Cristina Eller-Vainicher, Vincenzo Carnevale, Alfredo Scillitani, Domenico Rendina, Antonio S. Salcuni, Simone Cenci, Iacopo Chiodini, Luigi Gennari
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases. 33:158-167
Bone fragility is recognized as a complication of type 2 diabetes (T2D). However, the fracture risk in T2D is underestimated using the classical assessment tools. An expert panel suggested the diagnostic approaches for the detection of T2D patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7097aaabe492abb0c474aec63b7df564
https://doi.org/10.1016/j.numecd.2022.10.004
https://doi.org/10.1016/j.numecd.2022.10.004
Autor:
Taylor E. T. Hughes, Ruth A. Pumroy, Aysenur Torun Yazici, Marina A. Kasimova, Edwin C. Fluck, Kevin W. Huynh, Amrita Samanta, Sudheer K. Molugu, Z. Hong Zhou, Vincenzo Carnevale, Tibor Rohacs, Vera Y. Moiseenkova-Bell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and cal
Externí odkaz:
https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe21