Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Autor: Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood

Publikováno v: Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

Abstract In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle. The aim of the study w

Externí odkaz: https://doaj.org/article/957e9568d5be40668d33d9da2ecdf533

A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β-Hydroxybutyrate

Autor: Francesco Miceli, Lidia Carotenuto, Vincenzo Barrese, Maria Virginia Soldovieri, Erin L. Heinzen, Arthur M. Mandel, Natalie Lippa, Louise Bier, David B. Goldstein, Edward C. Cooper, Maria Roberta Cilio, Maurizio Taglialatela, Tristan T. Sands

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Pathogenic variants in KCNQ2 and KCNQ3, paralogous genes encoding Kv7.2 and Kv7.3 voltage-gated K+ channel subunits, are responsible for early−onset developmental/epileptic disorders characterized by heterogeneous clinical phenotypes ranging from b

Externí odkaz: https://doaj.org/article/05430e2eb7dd4b1fbcd4f49e2c141c8d

Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1

Autor: Samuel N. Baldwin, Elizabeth A. Forrester, Natalie Z. M. Homer, Ruth Andrew, Vincenzo Barrese, Jennifer B. Stott, Brant E. Isakson, Anthony P. Albert, Iain A. Greenwood

Publikováno v: Baldwin, S N, Forrester, E A, Homer, N Z M, Andrew, R, Barrese, V, Stott, J B, Isakson, B E, Albert, A P & Greenwood, I A 2022, ' Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1 ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15947

Background and purposeKcnq-encoded KV7 channels (termed KV7.1-5) regulate vascular smooth muscle cell (VSMC) contractility at rest and as downstream targets of receptor mediated responses. However, the current literature focuses predominantly on male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e0759f0cd9255b04c25a24fb956c0a
https://www.pure.ed.ac.uk/ws/files/313271074/British_J_Pharmacology_2022_Baldwin_Marked_oestrous_cycle_dependent_regulation_of_rat_arterial_KV7_4_channels_driven.pdf

Marked oestrous cycle-dependent regulation of rat arterial K

Autor: Samuel N, Baldwin, Elizabeth A, Forrester, Natalie Z M, Homer, Ruth, Andrew, Vincenzo, Barrese, Jennifer B, Stott, Brant E, Isakson, Anthony P, Albert, Iain A, Greenwood

Publikováno v: British journal of pharmacologyREFERENCES.

Kcnq-encoded KRT-qPCR, immunocytochemistry, proximity ligation assay and wire myography were performed in renal and mesenteric arteries. Circulating sex hormone concentrations were determined by liquid chromatography-tandem mass spectrometry. Whole-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78a9a1461ae21d9714d146660e14053f
https://pubmed.ncbi.nlm.nih.gov/36085551

Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction

Autor: Francesco Miceli, Maurizio Taglialatela, Piera Nappi, Vincenzo Barrese, Maria Virginia Soldovieri, Paolo Ambrosino

Publikováno v: Pflügers Archiv - European Journal of Physiology. 472:881-898

Seizures are the most common neurological manifestation in the newborn period, with an estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a detrimental effect on cognition and brain function in experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f8392984757182af8b3033a239961
https://doi.org/10.1007/s00424-020-02404-2