Výsledky vyhledávání - "Vincenza Vigorito"

The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

Autor: Matteo Burigotto, Vincenza Vigorito, Alessia Mattivi, Colin Gliech, Sabrina Ghetti, Alessandra Bisio, Graziano Lolli, Andrew J. Holland, Luca L. Fava

53BP1 acts at the crossroads between DNA repair and p53-mediated stress response. With its interactor USP28, it is part of the mitotic surveillance pathway (MSP), a sensor that monitors the duration of cell division, promoting p53-dependent cell cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acfd254c0ff9384c30a02d9e6455f34e
https://doi.org/10.1101/2023.03.27.534346

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Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splicing of FKBP51 immunophilin in melanoma patients

Autor: Fortunato Ciardiello, Paolo D’ Arrigo, Emilio Francesco Giunta, Giuseppe Argenziano, Vincenza Vigorito, Martina Tufano, Teresa Troiani, Simona Romano, Maria Romano

Publikováno v: British Journal of Cancer

Background FKBP51 immunophilin is abundantly expressed by immune cells. Co-inhibitory immune receptor signalling generates the splicing isoform FKBP51s. Tregs stained by FKBP51s are increased in melanoma patients and their counts are associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ae742bb21cf58f5c7b1918c9a43b2b
http://europepmc.org/articles/PMC7283486

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Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis

Autor: Paolo D'Arrigo, Vincenza Vigorito, Maria Fiammetta Romano, Simona Romano, Salvatore Russo, Martina Tufano

Publikováno v: Seminars in Cancer Biology. 60:181-190

Recent advances in tumor immunology, fostered by dramatic outcomes with cancer immunotherapy, have opened new scenarios in cancer metastasis. The cancer stemness/mesenchymal phenotype and an excess of immune suppressive signals are emerging as Intert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961a240939f45f36d2e1ba6429dfd48e
https://doi.org/10.1016/j.semcancer.2019.08.015

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The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation

Autor: Felix Hausch, Vincenza Vigorito, Salvatore Russo, Anna Rea, Michael Bauder, Marina Digregorio, Matthias Dedobbeleer, Paolo D'Arrigo, Martina Tufano, Maria Fiammetta Romano, Simona Romano, Bernard Rogister

Publikováno v: Cell Death Discovery
Cell Death Discovery, Vol 5, Iss 1, Pp 1-12 (2019)

Gliomas aberrantly express programmed cell death ligand-1 (PD-L1), which has a pivotal role in immunoevasion. The splicing isoform of FKBP5, termed FKBP51s, is a PD-L1 foldase, assisting the immune checkpoint molecule in maturation and expression on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facd291e8c6ca0be6f02680e1aebd8d5
https://pubmed.ncbi.nlm.nih.gov/31583120

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Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules

Autor: Maria Fiammetta Romano, Nunzia Novizio, Simona Romano, Vincenza Vigorito, Anna Rea, Martina Tufano, Salvatore Russo, Paolo D'Arrigo

Publikováno v: Current medicinal chemistry. 27(15)

The immune system actively counteracts the tumorigenesis process; a breakout of the immune system function, or its ability to recognize transformed cells, can favor cancer development. Cancer becomes able to escape from immune system control by using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48008a57b35d97e800d73e8c18798a9d
https://pubmed.ncbi.nlm.nih.gov/30398102

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Identification of a highly suppressive Treg subset associated to immunotherapy response

Autor: Martina Tufano, Simona Romano, Emilio Francesco Giunta, Maria Romano, D. Faicchia, Giuseppe Argenziano, Fortunato Ciardiello, N. Novizio, P. D'Arrigo, G. Matarese, Teresa Troiani, A. Rea, Vincenza Vigorito, C. Procaccini, V. De Falco

Publikováno v: Annals of Oncology. 29:viii31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1981ee502150916c6c45f7a8d13b0be
https://doi.org/10.1093/annonc/mdy269.096

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Abstract 5712: Identification of a highly suppressive Treg subset associated with immunotherapy response

Autor: Nunzia Novizio, Anna Rea, Maria Romano, Vincenza Vigorito, Paolo D'Arrigo, Deriggio Faicchia, Fortunato Ciardiello, Simona Romano, Martina Tufano, Teresa Troiani, Emilio Francesco Giunta, Giuseppe Argenziano, Claudio Procaccini, Giuseppe Matarrese

Publikováno v: Cancer Research. 78:5712-5712

Melanoma often exploits Treg to avoid immune attack. Treg is a heterogeneous population with respect to immunosuppressive capability. Lymphocytes are particularly rich in FKBP51 (encoded by FKBP5 gene), known as the receptor for FK506. Melanoma aberr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41870afb86b11bfb6ad8f958a3e65d0b
https://doi.org/10.1158/1538-7445.am2018-5712

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