Výsledky vyhledávání - "Vincenza Vigorito"

The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

Autor: Matteo Burigotto, Vincenza Vigorito, Alessia Mattivi, Colin Gliech, Sabrina Ghetti, Alessandra Bisio, Graziano Lolli, Andrew J. Holland, Luca L. Fava

53BP1 acts at the crossroads between DNA repair and p53-mediated stress response. With its interactor USP28, it is part of the mitotic surveillance pathway (MSP), a sensor that monitors the duration of cell division, promoting p53-dependent cell cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acfd254c0ff9384c30a02d9e6455f34e
https://doi.org/10.1101/2023.03.27.534346

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Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splicing of FKBP51 immunophilin in melanoma patients

Autor: Fortunato Ciardiello, Paolo D’ Arrigo, Emilio Francesco Giunta, Giuseppe Argenziano, Vincenza Vigorito, Martina Tufano, Teresa Troiani, Simona Romano, Maria Romano

Publikováno v: British Journal of Cancer

Background FKBP51 immunophilin is abundantly expressed by immune cells. Co-inhibitory immune receptor signalling generates the splicing isoform FKBP51s. Tregs stained by FKBP51s are increased in melanoma patients and their counts are associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ae742bb21cf58f5c7b1918c9a43b2b
http://europepmc.org/articles/PMC7283486

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Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis

Autor: Paolo D'Arrigo, Vincenza Vigorito, Maria Fiammetta Romano, Simona Romano, Salvatore Russo, Martina Tufano

Publikováno v: Seminars in Cancer Biology. 60:181-190

Recent advances in tumor immunology, fostered by dramatic outcomes with cancer immunotherapy, have opened new scenarios in cancer metastasis. The cancer stemness/mesenchymal phenotype and an excess of immune suppressive signals are emerging as Intert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961a240939f45f36d2e1ba6429dfd48e
https://doi.org/10.1016/j.semcancer.2019.08.015

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The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation

Autor: Felix Hausch, Vincenza Vigorito, Salvatore Russo, Anna Rea, Michael Bauder, Marina Digregorio, Matthias Dedobbeleer, Paolo D'Arrigo, Martina Tufano, Maria Fiammetta Romano, Simona Romano, Bernard Rogister

Publikováno v: Cell Death Discovery
Cell Death Discovery, Vol 5, Iss 1, Pp 1-12 (2019)

Gliomas aberrantly express programmed cell death ligand-1 (PD-L1), which has a pivotal role in immunoevasion. The splicing isoform of FKBP5, termed FKBP51s, is a PD-L1 foldase, assisting the immune checkpoint molecule in maturation and expression on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facd291e8c6ca0be6f02680e1aebd8d5
https://pubmed.ncbi.nlm.nih.gov/31583120

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Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules

Autor: Maria Fiammetta Romano, Nunzia Novizio, Simona Romano, Vincenza Vigorito, Anna Rea, Martina Tufano, Salvatore Russo, Paolo D'Arrigo

Publikováno v: Current medicinal chemistry. 27(15)

The immune system actively counteracts the tumorigenesis process; a breakout of the immune system function, or its ability to recognize transformed cells, can favor cancer development. Cancer becomes able to escape from immune system control by using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48008a57b35d97e800d73e8c18798a9d
https://pubmed.ncbi.nlm.nih.gov/30398102

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Abstract 5712: Identification of a highly suppressive Treg subset associated with immunotherapy response

Autor: Nunzia Novizio, Anna Rea, Maria Romano, Vincenza Vigorito, Paolo D'Arrigo, Deriggio Faicchia, Fortunato Ciardiello, Simona Romano, Martina Tufano, Teresa Troiani, Emilio Francesco Giunta, Giuseppe Argenziano, Claudio Procaccini, Giuseppe Matarrese

Publikováno v: Cancer Research. 78:5712-5712

Melanoma often exploits Treg to avoid immune attack. Treg is a heterogeneous population with respect to immunosuppressive capability. Lymphocytes are particularly rich in FKBP51 (encoded by FKBP5 gene), known as the receptor for FK506. Melanoma aberr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41870afb86b11bfb6ad8f958a3e65d0b
https://doi.org/10.1158/1538-7445.am2018-5712

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