Výsledky vyhledávání - "Vincenza Bagetta"

Akademický článek

l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation

Autor: Barbara Picconi, Vincent Paillé, Veronica Ghiglieri, Vincenza Bagetta, Ilaria Barone, Hanna S. Lindgren, Giorgio Bernardi, M. Angela Cenci, Paolo Calabresi

Publikováno v: Neurobiology of Disease, Vol 29, Iss 2, Pp 327-335 (2008)

The emergence of levodopa (l-DOPA)-induced dyskinesia and motor fluctuations represents a major clinical problem in Parkinson's disease (PD). While it has been suggested that the daily dose of l-DOPA can play a critical role, the mechanisms linking l

Externí odkaz: https://doaj.org/article/44836a8b76c643ed98d93b86ebf06c0d

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Akademický článek

Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia

Autor: Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Barbara Picconi, Paolo Calabresi

Publikováno v: Parkinson's Disease, Vol 2012 (2012)

In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the post

Externí odkaz: https://doaj.org/article/7973786e64b248b096cc08c3bca2f664

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Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

Autor: Valentina Pendolino, Vincenza Bagetta, Barbara Picconi, Cinzia Costa, Paolo Calabresi, Veronica Ghiglieri, Annabella Pignataro, Martine Ammassari-Teule, Anna Fejtova, Emanuela Morelli, Eckart D. Gundelfinger

Publikováno v: Experimental Neurology. 261:320-327

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17b6ba76f8a1b32d0fffec4e7312f7a
https://doi.org/10.1016/j.expneurol.2014.05.010

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Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism

Autor: Vincenza Bagetta, Valentina Pendolino, Monica Di Luca, Daniella Rylander, M. Angela Cenci, Elisa Zianni, Paolo Calabresi, Shane Grealish, Barbara Picconi, Fabrizio Gardoni

Publikováno v: Proceedings of the National Academy of Sciences; Vol 110

Intrastriatal transplantation of dopaminergic neurons can restore striatal dopamine levels and improve parkinsonian deficits, but the mechanisms underlying these effects are poorly understood. Here, we show that transplants of dopamine neurons partia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8267c8a9800663965c45528835d8466

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Memantine alters striatal plasticity inducing a shift of synaptic responses toward long-term depression

Autor: Valentina Pendolino, Maria Luisa Mancini, Desiree Mineo, Fabrizio Cacace, Paolo Calabresi, Barbara Picconi, Vincenza Bagetta, Veronica Ghiglieri, Anna Vannelli

Memantine is an open channel blocker that antagonizes NMDA receptors reducing the inappropriate calcium (Ca(2+)) influx occurring in presence of moderately increased glutamate levels. At the same time, memantine has the ability to preserve the transi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734780ab334267e3ed1c895d57336ba4
http://hdl.handle.net/10807/172031

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Functional interactions within striatal microcircuit in animal models of Huntington's disease

Autor: Paolo Calabresi, Veronica Ghiglieri, Vincenza Bagetta, Barbara Picconi

Publikováno v: Neuroscience. 211:165-184

Mutant huntingtin (mhtt) causes loss of synaptic plasticity and selective degeneration of striatal medium spiny neurons (MSNs), a core pathological feature of Huntington's disease (HD). However, projecting neurons become dysfunctional in the very ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9a8e8a8325254a8637349dac0ec56b
https://doi.org/10.1016/j.neuroscience.2011.06.075

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Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia

Autor: Vincenza Bagetta, Barbara Picconi, Valentina Pendolino, Veronica Ghiglieri, Paolo Calabresi

Publikováno v: Parkinson's Disease, Vol 2012 (2012)
Parkinson's Disease
Parkinson's Disease; Vol 2012

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75478544f35cea70e676f27948643ba0
https://doi.org/10.1155/2012/358176

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Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition

Autor: Paolo Calabresi, Carmelo Sgobio, Monica Di Luca, Carmela Giampà, Barbara Picconi, Vincenza Bagetta, Giorgio Bernardi, Veronica Ghiglieri, Maria Teresa Viscomi, Paul Greengard, Massimiliano Di Filippo, Francesca Fusco, Fabrizio Gardoni, Vincent Paillé

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2010, 30 (42), pp.14182-14193. ⟨10.1523/JNEUROSCI.2149-10.2010⟩
Journal of Neuroscience; Vol 30

A correct interplay between dopamine (DA) and glutamate is essential for corticostriatal synaptic plasticity and motor activity. In an experimental model of Parkinson's disease (PD) obtained in rats, the complete depletion of striatal DA, mimicking a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282b00f8d115cfa3e7eb1d2e67a601c7
https://doi.org/10.1523/jneurosci.2149-10.2010

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Synaptic dysfunction in Parkinson's disease

Autor: Vincenza Bagetta, Barbara Picconi, Paolo Calabresi, Carmelo Sgobio, Veronica Ghiglieri

Publikováno v: Biochemical Society Transactions. 38:493-497

In neuronal circuits, memory storage depends on activity-dependent modifications in synaptic efficacy, such as LTD (long-term depression) and LTP (long-term potentiation), the two main forms of synaptic plasticity in the brain. In the nucleus striatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b7aa94120fcbcbdff47f4af5d480b5
https://doi.org/10.1042/bst0380493

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Short-term and long-term plasticity at corticostriatal synapses: Implications for learning and memory

Autor: Barbara Picconi, Carmelo Sgobio, Michela Tantucci, Vincenza Bagetta, Veronica Ghiglieri, Massimiliano Di Filippo, Paolo Calabresi, Lucilla Parnetti, Alessandro Tozzi

Publikováno v: Behavioural Brain Research
Behavioural Brain Research; Vol 199

The striatum is the major division of the basal ganglia, representing the input station of the circuit and arguably the principal site within the basal ganglia where information processing occurs. Striatal activity is critically involved in motor con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f306f7f06e3d0d07b33b4f25c096d7c0

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