Výsledky vyhledávání - "Vincenza, Cantone"

A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors

Autor: Simona Pace, Vincenza Cantone, Dafne Ruggiero, Katrin Fischer, Stefania Terracciano, Oliver Werz, Giuseppe Bifulco, Ines Bruno, Gianluigi Lauro

Publikováno v: ChemMedChem. 15:481-489

Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO), two key enzymes involved in pro-inflammatory eicosanoid biosynthesis, represents a new strategy for treating inflammatory disorders. Herein we report the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220c5ef883ec1e0bf0dbefab5c052ff
https://doi.org/10.1002/cmdc.201900694

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Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol

Autor: Giuseppe Bifulco, Oliver Werz, Katrin Fischer, Andreas Koeberle, Vincenza Cantone, Marianna Potenza, Gianluigi Lauro, Raffaele Riccio

Publikováno v: MedChemComm. 9:2028-2036

Targeting microsomal prostaglandin E(2) synthase-1 (mPGES-1) represents an efficient strategy for the development of novel drugs against inflammation and cancer with potentially reduced side effects. With this aim, a virtual screening was performed o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4e97d7717d7f90ae43d39cbaf00f72
https://doi.org/10.1039/c8md00497h

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Anti-inflammatory and analgesic activity of carnosol and carnosic acidin vivoandin vitroandin silicoanalysis of their target interactions

Autor: Andreas Koeberle, Vincenza Cantone, Angela Bisio, Maria Giovanna Chini, Giovanni Romussi, Francesco Maione, Nicola Mascolo, Stefano Pieretti, Giuseppe Bifulco, Oliver Werz, Simona Pace

Publikováno v: British Journal of Pharmacology. 174:1497-1508

Background and Purpose The diterpenoids carnosol (CS) and carnosic acid (CA) from Salvia spp. exert prominent anti-inflammatory activities but their molecular mechanisms remained unclear. Here we investigated the effectiveness of CS and CA in inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cff21439e71bbb3ba65301a5aa27d9c
https://doi.org/10.1111/bph.13545

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Discovery of new potent molecular entities able to inhibit mPGES-1

Autor: Giuseppe Bifulco, Raffaele Riccio, Vincenza Cantone, Ines Bruno, Oliver Werz, Simone Di Micco, Stefania Terracciano, Katrin Fischer, Andreas Koeberle, Antonio Foglia

Publikováno v: European journal of medicinal chemistry. 143

mPGES-1, a glutathione-dependent membrane protein is involved in the last step of PGE2 production and has been well recognized as a strategic target for the development of anti-inflammatory and anti-cancer agents. It has been proven to selectively co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0520e39480b63853779300190c6abf5c
https://pubmed.ncbi.nlm.nih.gov/29133047

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Cyclic Diarylheptanoids from Corylus avellana Green Leafy Covers: Determination of Their Absolute Configurations and Evaluation of Their Antioxidant and Antimicrobial Activities

Autor: Beata Olas, Antonietta Cerulli, Gianluigi Lauro, Vincenza Cantone, Sonia Piacente, Bogdan Kontek, Giuseppe Bifulco, Milena Masullo, Filomena Nazzaro

Publikováno v: Journal of natural products. 80(6)

The methanol extract of the leafy covers of Corylus avellana, source of the Italian PGI (protected geographical indication) product “Nocciola di Giffoni”, afforded two new cyclic diarylheptanoids, giffonins T and U (2 and 3), along with two known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fbc2f965844a25441d8ea8a745dd56
https://pubmed.ncbi.nlm.nih.gov/28520428

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