Modeling cancer-associated hypercoagulability using glioblastoma spheroids in microfluidic chips

Autor: Maaike Y. Kapteijn, Monika Yanovska, El Houari Laghmani, Rudmer J. Postma, Vincent van Duinen, Betül Ünlü, Karla Queiroz, Anton Jan van Zonneveld, Henri H. Versteeg, Araci M.R. Rondon

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102475- (2024)

Background: Cancer increases the risk of venous thromboembolism, and glioblastoma is one of the cancer types with the highest risk of venous thromboembolism (10%-30%). Tumor-intrinsic features are believed to affect vascular permeability and hypercoa

Externí odkaz: https://doaj.org/article/97a8c772b0a14681b54af697776277b4

Ebola Hemorrhagic Shock Syndrome-on-a-Chip

Autor: Abidemi Junaid, Huaqi Tang, Anne van Reeuwijk, Yasmine Abouleila, Petra Wuelfroth, Vincent van Duinen, Wendy Stam, Anton Jan van Zonneveld, Thomas Hankemeier, Alireza Mashaghi

Publikováno v: iScience, Vol 23, Iss 1, Pp - (2020)

Summary: Ebola virus, for which we lack effective countermeasures, causes hemorrhagic fever in humans, with significant case fatality rates. Lack of experimental human models for Ebola hemorrhagic fever is a major obstacle that hinders the developmen

Externí odkaz: https://doaj.org/article/c1c4a78e64754fbba25ceb053ca1418c

A microfluidics-based screening tool to assess the impact of blood plasma factors on microvascular integrity

Autor: Sophie Dólleman, Abidemi Junaid, Hendrik Endeman, Cees van Kooten, Thomas Hankemeier, Wendy Stam, Alireza Mashaghi, Wei Yang, Vincent van Duinen, Hetty C. de Boer, Yolanda B. de Rijke, Anton Jan van Zonneveld, Janine M. van Gils

Publikováno v: Advanced Biology, 5(11). WILEY-V C H VERLAG GMBH
Advanced Biology, 5(11):2100954. Wiley-VCH

This study provides a method to assess the impact of circulating plasma factors on microvascular integrity by using a recently developed microvessel-on-a-chip platform featuring the human endothelium that is partly surrounded by the extracellular mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d23080402f3649f686860ec736021b
http://hdl.handle.net/1887/3248555

Ebola hemorrhagic shock syndrome-on-a-chip

Autor: Alireza Mashaghi, Vincent van Duinen, Petra Wuelfroth, Wendy Stam, Huaqi Tang, Anne van Reeuwijk, Thomas Hankemeier, Yasmine Abouleila, Abidemi Junaid, Anton Jan van Zonneveld

Publikováno v: iScience, 23(1). CELL PRESS
iScience, Vol 23, Iss 1, Pp-(2020)
iScience
iScience, 23(1), 100765

Summary Ebola virus, for which we lack effective countermeasures, causes hemorrhagic fever in humans, with significant case fatality rates. Lack of experimental human models for Ebola hemorrhagic fever is a major obstacle that hinders the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508463617d88ec29b1e8afa32dd3d33
http://hdl.handle.net/1887/3181558

Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells

Autor: Bahar Yetkin-Arik, Vincent van Duinen, C. J. F. Van Noorden, Ilse M. C. Vogels, N. Neyazi, Ingeborg Klaassen, Riekelt H. Houtkooper, R. O. Schlingemann

Publikováno v: Scientific Reports
Scientific reports, 9(1):10414. Nature Publishing Group
Scientific Reports, 9(1):10414. Nature Publishing Group
Scientific reports, vol. 9, no. 1, pp. 10414
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports, 9. NATURE PUBLISHING GROUP

Formation of new blood vessels by differentiated endothelial tip cells, stalk cells, and phalanx cells during angiogenesis is an energy-demanding process. How these specialized endothelial cell phenotypes generate their energy, and whether there are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1683361fdc71ed818f6a2c29f563dc1
https://doi.org/10.1038/s41598-019-46503-2