Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Xiaozhe Zhang, Gao Shan, Na Li, Jingyi Chen, Changyang Ji, Xiaoxiao Li, Liwen Jiang, Terence Kin Wah Lee, Vincent W. Keng, Yanxiang Zhao
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Autophagy is a lysosome-dependent bulk degradation process essential for cell viability but excessive autophagy leads to a unique form of cell death termed autosis. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breas
Externí odkaz:
https://doaj.org/article/208f1364bbdd4bc1ae0a42feda441890
Autor:
Vincent W. Keng, Amy P. Chiu, Jeffrey C. To, Xiao-Xiao Li, Michael A. Linden, Khalid Amin, Branden S. Moriarity, Kosuke Yusa
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18774- (2023)
Various molecular subclasses of hepatocellular carcinoma (HCC) exists, with many novel cooperating oncogenes and tumor suppressor genes involved in its tumorigenesis. The emerging importance of WNT signaling in HCC has been established. However, the
Externí odkaz:
https://doaj.org/article/3ec97fec72204a5396822e207512d266
Publikováno v:
Cancers, Vol 15, Iss 21, p 5280 (2023)
Drug resistance poses a great challenge in systemic therapy for hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms associated with resistance to anti-cancer drugs, such as Sorafenib, remain unclear. In this study, we use tra
Externí odkaz:
https://doaj.org/article/3f3ccd63c12b4525acf9f5b8487919d9
Autor:
Caitlin B. Conboy, Germán L. Vélez‐Reyes, Barbara R. Tschida, Hsiangyu Hu, Gabriel Kaufmann, Nicholas Koes, Bryant Keller, Clara Alsinet, Helena Cornellà, Roser Pinyol, Juan E. Abrahante, Nuri A. Temiz, Michael A. Linden, Khalid Amin, Timothy P. Kuka, Vincent W. Keng, Josep M. Llovet, Timothy K. Starr, David A. Largaespada
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Externí odkaz:
https://doaj.org/article/0eab1ccaa58a47a08d90c0ba26613dba
Autor:
Jeffrey C. To, Amy P. Chiu, Barbara R. Tschida, Lilian H. Lo, Cynthia H. Chiu, Xiao-Xiao Li, Timothy P. Kuka, Michael A. Linden, Khalid Amin, Wing-Cheung Chan, Jason B. Bell, Branden S. Moriarity, David A. Largaespada, Vincent W. Keng
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100223- (2021)
Background & Aims: Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be a transcriptional repressor of the alpha-foetoprotein (Afp) gene in adult
Externí odkaz:
https://doaj.org/article/58dd8d290ff94e908089e3e2954c131c
Autor:
Xiao-Xiao Li, Xin-Yi Lu, Shi-Jie Zhang, Amy P. Chiu, Lilian H. Lo, David A. Largaespada, Qu-Bo Chen, Vincent W. Keng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 68-75 (2019)
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodi
Externí odkaz:
https://doaj.org/article/d5d1f980eefd4833b64310bb64a98aeb
Autor:
Xiao-Xiao Li, Shi-Jie Zhang, Amy P. Chiu, Lilian H. Lo, Jeffery C. To, He-Ning Cui, Dewi K. Rowlands, Vincent W. Keng
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 297-303 (2019)
The neuromuscular junction (NMJ) consists of three components, namely presynaptic motor neurons, postsynaptic muscle fibers and perisynaptic Schwann cells (PSCs). The role of Schwann cells (SCs) in regulating NMJ structural and functional development
Externí odkaz:
https://doaj.org/article/cb044028831c4089ab53c30c7f013f28
Autor:
Xiao‐Xiao Li, Shi‐Jie Zhang, Amy P. Chiu, Lilian H. Lo, Jian Huang, Dewi K. Rowlands, Jinhui Wang, Vincent W. Keng
Publikováno v:
Cancer Medicine, Vol 7, Iss 9, Pp 4791-4800 (2018)
Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with
Externí odkaz:
https://doaj.org/article/0db10cd2d8874526bbe8274b43af2f43
Autor:
Jianqiang Wu, Vincent W. Keng, Deanna M. Patmore, Jed J. Kendall, Ami V. Patel, Edwin Jousma, Walter J. Jessen, Kwangmin Choi, Barbara R. Tschida, Kevin A.T. Silverstein, Danhua Fan, Eric B. Schwartz, James R. Fuchs, Yuanshu Zou, Mi-Ok Kim, Eva Dombi, David E. Levy, Gang Huang, Jose A. Cancelas, Anat O. Stemmer-Rachamimov, Robert J. Spinner, David A. Largaespada, Nancy Ratner
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway that becom
Externí odkaz:
https://doaj.org/article/b85859bc4dea43bd98344313076ad5bb
Autor:
Vincent W. Keng, Adrienne L. Watson, Eric P. Rahrmann, Hua Li, Barbara R. Tschida, Branden S. Moriarity, Kwangmin Choi, Tilat A. Rizvi, Margaret H. Collins, Margaret R. Wallace, Nancy Ratner, David A. Largaespada
Publikováno v:
Sarcoma, Vol 2012 (2012)
The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hy
Externí odkaz:
https://doaj.org/article/47da9adc73ef4a64bea05365ec9576c1