Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vincent Van Hoef"'
Autor:
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting i
Externí odkaz:
https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
Autor:
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH
Externí odkaz:
https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
Autor:
Annelies Verbiest, Vincent Van Hoef, Cristina Rodriguez-Antona, Jesús García-Donas, Osvaldo Graña-Castro, Maarten Albersen, Marcella Baldewijns, Annouschka Laenen, Eduard Roussel, Patrick Schöffski, Agnieszka Wozniak, Stefano Caruso, Gabrielle Couchy, Jessica Zucman-Rossi, Benoit Beuselinck
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238809 (2020)
Clear-cell renal cell carcinomas (ccRCC) can be divided into four transcriptomic subtypes, two of which have a favorable and two an unfavorable prognosis. To assess mechanisms driving these subtypes, we investigated their miRNA expression patterns. m
Externí odkaz:
https://doaj.org/article/30baa197e6f241efb27d73daebcccfed
Autor:
Maria Hatzoglou, Cedric Darini, Nour Ghaddar, John Le Quesne, Myriam Johnson, Ola Larsson, Leah Officer, Antonis E. Koromilas, Jothilatha Krishnamoorthy, Bethany Woodvine, Shuo Wang, Koren K. Mann, Vincent van Hoef, H. Popper, Massimo Broggini, Ivan Topisirovic, Ana Teodósio, Urszula Kazimierczak, Nicolas Ah-son
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a5c15cd00a31ef21743e79af306587
https://www.repository.cam.ac.uk/handle/1810/327411
https://www.repository.cam.ac.uk/handle/1810/327411
Autor:
Stefano Caruso, Jesús García-Donas, Vincent van Hoef, Maarten Albersen, Marcella Baldewijns, Annouschka Laenen, Cristina Rodríguez-Antona, Jessica Zucman-Rossi, Agnieszka Wozniak, Benoit Beuselinck, Annelies Verbiest, Osvaldo Graña-Castro, Patrick Schöffski, Eduard Roussel, Gabrielle Couchy
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238809 (2020)
Instituto de Salud Carlos III (ISCIII)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238809 (2020)
Clear-cell renal cell carcinomas (ccRCC) can be divided into four transcriptomic subtypes, two of which have a favorable and two an unfavorable prognosis. To assess mechanisms driving these subtypes, we investigated their miRNA expression patterns. m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbba4258bec0878a89ea6007db77070e
https://hdl.handle.net/20.500.12105/12982
https://hdl.handle.net/20.500.12105/12982
Autor:
Anne Laure Joly, Christina Seitz, Samuel E.J. Preston, Majken Wallerius, Talin Ebrahimian, Stephanie Lehoux, Sonia V. del Rincón, Jonas Bergh, Ola Larsson, Johannes Ristau, Kristian Pietras, Laia Masvidal, Yangxun Pan, John Andersson, Mario Leonardo Squadrito, Christophe Goncalves, Luigi Naldini, Tatjana Wallmann, Hui Liu, Thomas Kerzel, Margarita Bartish, Sabrina de Souza Ferreira, Dongmei Tong, Charlotte Rolny, Vincent van Hoef
Publikováno v:
Proc Natl Acad Sci U S A
Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1704cb457e1d097f850f59c19770dc73
Autor:
Johannes Ristau, Shuo Liang, Galina Selivanova, Ivan Topisirovic, Sylvain Peuget, Vincent van Hoef, Jiawei Zhu, Ola Larsson, Maria Hatzoglou, Bo-Jhih Guan
Publikováno v:
Cell Death and Disease, Vol 10, Iss 11, Pp 1-12 (2019)
Cell Death & Disease
Cell Death & Disease
Tumor protein 53 (p53, encoded by the TP53 gene) is a key tumor suppressor regulating cell fates in response to internal and external stresses. As TP53 is mutated or silenced in a majority of tumors, reactivation of p53 by small molecules represents
Autor:
Eric P Kusnadi, Sebastian A. Leidel, Vincent van Hoef, Krzysztof J. Szkop, Matthew Leibovitch, Julie Lorent, Gail P. Risbridger, Preetika Balanathan, Ola Larsson, Baila Samreen, Johannes Ristau, Qishan Lin, Pierre Close, Shan Chen, Karin Scharmann, Francesca Rapino, Ivan Topisirovic, Richard J. Rebello, Luke A. Selth, Itsuhiro Takizawa, Patricia Bukczynska, Mitchell G. Lawrence, Luc Furic
Publikováno v:
The EMBO Journal. 38
Estrogen receptor alpha (ERα) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ERα on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demo
Autor:
Salendra Singh, Vasilios Papavasiliou, Catherine R. Dufour, Jane Beith, Ipshita Nandi, Eran R. Andrechek, Virginie Sanguin-Gendreau, Ewan K.A. Millar, Lyndsay Harris, Asier Unciti-Broceta, Mark Basik, Harvey W. Smith, Sandra A O'Toole, Carolin Temps, Vincent van Hoef, Vinay Varadan, Vincent Giguère, Cynthia Lavoie, Matthew R. Swiatnicki, Ola Larsson, Paul Savage, Alison Hirukawa, Kristofferson Tandoc, Jonathan P. Rennhack, Christina I. Selinger, Matthew Leibovitch, Neil O. Carragher, Ana Cristina Vargas Calderon, Ivan Topisirovic, Dongmei Zuo, Morag Park, Caroline Cooper, William J. Muller
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH
Autor:
Eric P Kusnadi, Itsuhiro Takizawa, Vincent van Hoef, Gail P. Risbridger, Julie Lorent, Richard J. Rebello, Ola Larsson, Sebastian A. Leidel, Mitchell G. Lawrence, Luc Furic, Preetika Balanathan, Baila Samreen, Karin Scharmann, Krzysztof J. Szkop, Ivan Topisirovic
Estrogen receptor alpha (ERα) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ERα on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0c295f5671992df365c20a01c1de05
https://doi.org/10.1101/507574
https://doi.org/10.1101/507574