Data from Motexafin Gadolinium Disrupts Zinc Metabolism in Human Cancer Cell Lines

Autor: Joseph G. Hacia, Mazen W. Karaman, Shailender Nagpal, Danny Chawannakul, Vincent V. Ho, John E. Biaglow, Mimi Mesfin, Dale Miles, Cheryl Lepp, Richard A. Miller, Philip Lecane, Darren Magda

To gain a better understanding of the mechanism of action of the metal cation–containing chemotherapeutic drug motexafin gadolinium (MGd), gene expression profiling analyses were conducted on plateau phase human lung cancer (A549) cell cultures tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fb0062de37344a6661265c9df619aa
https://doi.org/10.1158/0008-5472.c.6494472.v1

Mutation and genomic deletion status of ataxia telangiectasia mutated ( ATM ) and p53 confer specific gene expression profiles in mantle cell lymphoma

Autor: Hans K. Müller-Hermelink, Elaine S. Jaffe, James O. Armitage, Michael Y. Im, Jan Delabie, Julie M. Vose, Wing C. Chan, Dennis D. Weisenburger, Randy D. Gascoyne, Rita M. Braziel, Lynette M. Smith, Chiranjib Dasgupta, Timothy C. Greiner, Brian L. Pike, Joseph G. Hacia, Elias Campo, German Ott, Mazen W. Karaman, Andreas Rosenwald, Kai Fu, Vincent V. Ho, Louis M. Staudt, James C. Lynch

Publikováno v: Proceedings of the National Academy of Sciences. 103:2352-2357

Although mantle cell lymphoma (MCL) frequently harbors inactivated ataxia telangiectasia mutated ( ATM ) and p53 alleles, little is known about the molecular phenotypes caused by these genetic changes. We identified point mutations and genomic deleti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e81d12b91e3264d9ace6c3507eac44
https://doi.org/10.1073/pnas.0510441103

Gene expression profiling of glucocorticoid-inhibited osteoblasts

Autor: Baruch Frenkel, Shailender Nagpal, Cynthia A. Luppen, Joseph G. Hacia, Nathalie Leclerc, Vincent V. Ho, Elisheva Smith

Publikováno v: Journal of molecular endocrinology. 33(1)

Glucocorticoid (GC) treatment for the management of autoimmune and inflammatory diseases is associated with decreased bone formation and increased risk for fracture. In MC3T3-E1 cell cultures, 0.1-1 microM dexamethasone (DEX) arrests development of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5257cd8341b9227e87a6528cb7c58e3c
https://pubmed.ncbi.nlm.nih.gov/15291752

Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts

Autor: Shailender Nagpal, Marlys L. Houck, Brian L. Pike, Dominick Sudano, Daniel Chawannakul, Mazen W. Karaman, Leona G. Chemnick, Vincent V. Ho, Joseph G. Hacia, Oliver A. Ryder

Publikováno v: Genome research. 13(7)

Although much is known about genetic variation in human and African great ape (chimpanzee, bonobo, and gorilla) genomes, substantially less is known about variation in gene-expression profiles within and among these species. This information is neces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8123cbaa735700bb0016fb48778072dd
https://pubmed.ncbi.nlm.nih.gov/12840040

Saturation mutagenesis-reinforced functional assays for disease-related genes.

Autor: Ma K; Department of Genetics, Yale School of Medicine, New Haven, CT, USA; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. Electronic address: kaiyue.ma@yale.edu., Huang S; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Ng KK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Lake NJ; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Joseph S; Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA., Xu J; Yale University, New Haven, CT, USA., Lek A; Department of Genetics, Yale School of Medicine, New Haven, CT, USA; Muscular Dystrophy Association, Chicago, IL, USA., Ge L; Department of Genetics, Yale School of Medicine, New Haven, CT, USA; Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China., Woodman KG; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Koczwara KE; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Cohen J; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Ho V; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., O'Connor CL; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Brindley MA; Department of Infectious Diseases, Department of Population Health, University of Georgia, Athens, GA, USA., Campbell KP; Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA., Lek M; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Electronic address: monkol.lek@yale.edu.

Publikováno v: Cell [Cell] 2024 Nov 14; Vol. 187 (23), pp. 6707-6724.e22. Date of Electronic Publication: 2024 Sep 25.