Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vincent U. Gant"'
Autor:
Amanuel Tafessu, Ryan O’Hara, Sara Martire, Altair L. Dube, Purbita Saha, Vincent U. Gant, Laura A. Banaszynski
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible, creating an environment that is permissive to transcription factor bindi
Externí odkaz:
https://doaj.org/article/70c0edbf42d747d79aaca773ca4fb92b
Autor:
Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by
Externí odkaz:
https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
Autor:
Aishwarya Sundaresan, Laura A. Banaszynski, Vincent U. Gant, Jane N. Warshaw, Yu-Ching Teng, Sara Martire, Amrita Basu, Ryan O’Hara, Minhua Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes
Autor:
Vincent U. Gant, D. Williams Parsons, Christine M. Yost, Amos Gaikwad, Kevin E. Fisher, Karen R. Rabin, Andrea N. Marcogliese, Eric S. Schafer
Publikováno v:
Leukemia & Lymphoma. 61:3515-3518
Lineage switch in acute leukemia is rare – with the reported incidence across studies ranging from 0.6% of all leukemias to 6% of relapsed leukemias [1,2] – and strongly associated with presence of...
Autor:
Jacob J. Junco, Barry Zorman, Vincent U. Gant, Jaime Muñoz, H. Daniel Lacorazza, Pavel Sumazin, Karen R. Rabin
Publikováno v:
Exp Hematol
Children with Down syndrome (DS) are 10-fold more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), with a higher frequency of rearrangements resulting in overexpression of cytokine receptor-like factor 2 (CRLF2). Here, we investigated t
Autor:
Noah A. Kallsen, Charles G. Mullighan, Jun J. Yang, Karen R. Rabin, Jasmine Healy, Catherine Metayer, Michael E. Scheurer, Andrew J. Carroll, Jonathan M. Chernus, Nyla A. Heerema, Logan G. Spector, Andrew T. DeWan, Gareth E. Davies, Mignon L. Loh, Shanna A. Peyton, Eleanor Feingold, Philip J. Lupo, Naomi J. Winick, Daniel Sinnett, William L. Carroll, Lisa F. Barcellos, Stephen P. Hunger, Austin L. Brown, Stephanie L. Sherman, Libby M. Morimoto, Mary V. Relling, Maria S. Pombo-de-Oliveira, Erik A. Ehli, Beth A. Mueller, Xiaomei Ma, Ivan Smirnov, Ching-Hon Pui, Vincent U. Gant, Brent L. Wood, Helen M. Hansen, Elizabeth A. Raetz, Pamela D. Thompson, Jillian M. Birch, Alice Y. Kang, Kyle M. Walsh, Adam J. de Smith, Wenjian Yang, Meenakshi Devidas, Joseph L. Wiemels, Jeffrey W. Taub, Caroline Laverdière, Michael J. Borowitz, Michael E. Zwick
Publikováno v:
Blood. 134:1227-1237
Children with Down syndrome (DS) have a 20-fold increased risk of acute lymphoblastic leukemia (ALL) and distinct somatic features, including CRLF2 rearrangement in ∼50% of cases; however, the role of inherited genetic variation in DS-ALL susceptib
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0244863 (2021)
PLoS ONE, Vol 16, Iss 1, p e0244863 (2021)
Children with Down syndrome have an approximately 10-fold increased risk of developing acute lymphoblastic leukemia and this risk is influenced by inherited genetic variation. Genome-wide association studies have identified IKZF1 as a strong acute ly
Autor:
Christine M, Yost, Amos S, Gaikwad, D Williams, Parsons, Karen R, Rabin, Vincent U, Gant, Kevin E, Fisher, Andrea N, Marcogliese, Eric S, Schafer
Publikováno v:
Leukemialymphoma. 61(14)
Autor:
Taylor Chen, Karen R. Rabin, Rachel E. Rau, Maci Terrell, H. Daniel Lacorazza, Jacob J. Junco, Matthew Miller, Vincent U. Gant, Raushan Rashid
Publikováno v:
Leukemia
Oshima K, Khiabanian H, da Silva-Almeida AC, Tzoneva G, Abate F, Ambesi-Impiombato A, et al. Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 2016;113:11306
Autor:
Maci S. Terrell, Rachel E. Rau, Taylor J Chen, Margaret A. Goodell, Karen R. Rabin, Chun Shik Park, H. Daniel Lacorazza, Matthew Miller, Vincent U. Gant, Jacob J. Junco
Publikováno v:
Blood. 134:3792-3792
Introduction: RAS-activating mutations are common in both childhood B- and T-acute lymphoblastic leukemia (ALL). Prior studies of B- and T-ALL have shown that RAS mutations become enriched during treatment in minimum residual disease-positive cases,