Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Vincent U Gant"'
1
Akademický článek
Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds.
Autor: Vincent U Gant, Jacob J Junco, Maci Terrell, Raushan Rashid, Karen R Rabin
Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0244863 (2021)
Children with Down syndrome have an approximately 10-fold increased risk of developing acute lymphoblastic leukemia and this risk is influenced by inherited genetic variation. Genome-wide association studies have identified IKZF1 as a strong acute ly
Externí odkaz: https://doaj.org/article/cb79d0cea4ee4644865f6af9b56eaae2
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2
Akademický článek
H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
Autor: Amanuel Tafessu, Ryan O’Hara, Sara Martire, Altair L. Dube, Purbita Saha, Vincent U. Gant, Laura A. Banaszynski
Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible, creating an environment that is permissive to transcription factor bindi
Externí odkaz: https://doaj.org/article/70c0edbf42d747d79aaca773ca4fb92b
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3
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
Autor: Aishwarya Sundaresan, Laura A. Banaszynski, Vincent U. Gant, Jane N. Warshaw, Yu-Ching Teng, Sara Martire, Amrita Basu, Ryan O’Hara, Minhua Li
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX sensitizes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a6e3860623ad29f4b0fe8ea47fdd07
https://doaj.org/article/c9b46c0c43fd49e8b61774788526fb9b
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4
Aberrant leukemia-associated immunophenotype as potential harbinger of lineage switch in KMT2A-rearranged leukemia: a case series
Autor: Vincent U. Gant, D. Williams Parsons, Christine M. Yost, Amos Gaikwad, Kevin E. Fisher, Karen R. Rabin, Andrea N. Marcogliese, Eric S. Schafer
Publikováno v: Leukemia & Lymphoma. 61:3515-3518
Lineage switch in acute leukemia is rare – with the reported incidence across studies ranging from 0.6% of all leukemias to 6% of relapsed leukemias [1,2] – and strongly associated with presence of...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d302f88fbe66e3ba619eb921b8ae6f58
https://doi.org/10.1080/10428194.2020.1815018
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5
CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome
Autor: Jacob J. Junco, Barry Zorman, Vincent U. Gant, Jaime Muñoz, H. Daniel Lacorazza, Pavel Sumazin, Karen R. Rabin
Publikováno v: Exp Hematol
Children with Down syndrome (DS) are 10-fold more likely to develop B-cell acute lymphoblastic leukemia (B-ALL), with a higher frequency of rearrangements resulting in overexpression of cytokine receptor-like factor 2 (CRLF2). Here, we investigated t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a98245766c54651fc9c9d125f82c5c
https://pubmed.ncbi.nlm.nih.gov/35306048
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7
Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds
Autor: Jacob J. Junco, Karen R. Rabin, Vincent U. Gant, Raushan Rashid, Maci Terrell
Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0244863 (2021)
Children with Down syndrome have an approximately 10-fold increased risk of developing acute lymphoblastic leukemia and this risk is influenced by inherited genetic variation. Genome-wide association studies have identified IKZF1 as a strong acute ly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df808e005892e48a5881dc1bf5c045b6
http://europepmc.org/articles/PMC7790404
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9
An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance
Autor: Taylor Chen, Karen R. Rabin, Rachel E. Rau, Maci Terrell, H. Daniel Lacorazza, Jacob J. Junco, Matthew Miller, Vincent U. Gant, Raushan Rashid
Publikováno v: Leukemia
Oshima K, Khiabanian H, da Silva-Almeida AC, Tzoneva G, Abate F, Ambesi-Impiombato A, et al. Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 2016;113:11306
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e123c199d1d41cae46203965562aec37
https://pubmed.ncbi.nlm.nih.gov/32918044
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10
Random amplified polymorphic DNA reveals that TiO2 nanoparticles are genotoxic to Cucurbita pepo
Autor: Vincent U. Gant, Jose R. Peralta-Videa, Jorge L. Gardea-Torresdey, Fabiola Moreno-Olivas, Kyle L. Johnson
Publikováno v: Journal of Zhejiang University SCIENCE A. 15:618-623
Titanium dioxide nanoparticles (TiO2 NPs) are used in cosmetics, sunscreens, paints, and toothpaste, among other applications. These NPs are very stable and can be transported and dispersed in wastewater and biosolids. Animal species have shown negat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02a53ddba682fe57ec0edfd4b7ca30f1
https://doi.org/10.1631/jzus.a1400159
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