Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Vincent Tong"'
Autor:
Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 2010-2023 (2022)
Abstract RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to
Externí odkaz:
https://doaj.org/article/b9ff23b0f0ad4f13a0f534eb7f32e626
Autor:
Robert A. Craig, Brian M. Fox, Cheng Hu, Katrina W. Lexa, Maksim Osipov, Arun P. Thottumkara, Martin Larhammar, Takashi Miyamoto, Anil Rana, Lesley A. Kane, Ernie Yulyaningsih, Hilda Solanoy, Hoang Nguyen, Roni Chau, Timothy Earr, Yuji Kajiwara, Daniel Fleck, Anthony Lucas, Patrick C. G. Haddick, Ryan H. Takahashi, Vincent Tong, Jing Wang, Mark J. Canet, Suresh B. Poda, Kimberly Scearce-Levie, Ankita Srivastava, Zachary K. Sweeney, Musheng Xu, Rui Zhang, Jianrong He, Yanan Lei, Zheng Zhuo, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 65:16290-16312
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative diseases. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba59c66263d4a021ad8e4342b49383cd
https://doi.org/10.1021/acs.jmedchem.2c01056
https://doi.org/10.1021/acs.jmedchem.2c01056
Autor:
Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho
Publikováno v:
Clinical and Translational Science. 15:2010-2023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95cdda02d84a3c460709facb87673a93
https://doi.org/10.1111/cts.13317
https://doi.org/10.1111/cts.13317
Autor:
Benjamin Wesley Trotter, Xavier Fradera, Stephen E. Alves, Meredeth A. McGowan, Peter Goldenblatt, Jason D. Katz, Yudith Garcia, Lynsey Shaffer, Michael D. Altman, Matthew Christopher, Kathryn Lipford, Charles A. Lesburg, Hyun-Hee Lee, Chaomin Li, Craig P. Chappell, Vincent Tong, Elaine M. Pinheiro, Armetta D. Hill, Ruban Mangado, Renu Jain, Robbie L. McLeod, Sanjiv J. Shah, Hongshi Yu, Abdelghani Achab, Dapeng Chen, Joey L. Methot, Sybill M G Williams, Hua Zhou, Neville J. Anthony
Publikováno v:
Journal of medicinal chemistry. 64(8)
The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our program led to the identification of structurally distinct heterocycloalkyl purine inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a62dfaa61d20ec22ebc7d156d70d73
https://pubmed.ncbi.nlm.nih.gov/33797901
https://pubmed.ncbi.nlm.nih.gov/33797901
Autor:
Michael D. Altman, Jason D. Katz, Hua Zhou, Joey L. Methot, Vincent Tong, Kevin J. Wilson, Yudith Garcia, Peter Goldenblatt, Abdelganhi Achab, Martin Augustin, Charles A. Lesburg, Qiaolin Deng, Solomon Kattar, Lynsey Shaffer, Xavier Fradera, Meredeth A. McGowan, Sanjiv J. Shah
Publikováno v:
Bioorganicmedicinal chemistry letters. 42
PI3K-δ mediates key immune cell signaling pathways and is a target of interest for treatment of oncological and immunological disorders. Here we describe the discovery and optimization of a novel series of PI3K-δ selective inhibitors. We first iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9bff15a42c345e0eae2a3ff5da3cf0
https://pubmed.ncbi.nlm.nih.gov/33865969
https://pubmed.ncbi.nlm.nih.gov/33865969
Autor:
Qiaoling Deng, Feroze Ujjainwalla, F. Anthony Romero, Jenna L. Terebetski, Jerry Di Salvo, Ying Li, Dorina Trusca, Ming Wang, Nicholas B. Hastings, Remond Moningka, Vincent Tong, Zhiqiang Guo, Richard G. Ball
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(23)
Here, we report the discovery of a new class of NPBWR1 antagonists identified from a fragment-based screen. Compound 1 (cAMP IC50 = 250 µM; LE = 0.29) emerged as an initial hit. Further optimization of 1 by SAR-by-catalogue and chemical modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e4a6a9cbe7d66ea64b2f90c58c7963
https://pubmed.ncbi.nlm.nih.gov/32898693
https://pubmed.ncbi.nlm.nih.gov/32898693
Autor:
Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2559-2566
SAR in the previously described spirocyclic ROMK inhibitor series was further evolved from lead 4 by modification of the spirocyclic core and identification of novel right-side pharmacophores. In this process, it was discovered that the spiropyrrolid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086
https://doi.org/10.1016/j.bmcl.2017.03.086
Autor:
Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1109-1114
A spirocyclic class of ROMK inhibitors was developed containing a structurally diverse heterocyclic sulfone moiety and spirocyclic core starting from lead 1. These compounds not only displayed exquisite ROMK potency but significantly improved selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5ab8a2efa0d6babaaad56a9277a67
https://doi.org/10.1016/j.bmcl.2016.10.032
https://doi.org/10.1016/j.bmcl.2016.10.032
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122
