Výsledky vyhledávání - "Vincent T. Grattan"

A randomized, double-blind, placebo controlled, phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of LB-102, a selective dopamine D2/3/5-HT7 inhibitor

Autor: Lukasz Biernat, Vincent T. Grattan, Mark S. Hixon, Zachary Prensky, Andrew R. Vaino

Publikováno v: Psychopharmacology. 239:3009-3018

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15a77d04d2dc7950c4e6d73a1270c03f
https://doi.org/10.1007/s00213-022-06185-7

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A randomized, double-blind, placebo controlled, phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of LB-102, a selective dopamine D

Autor: Lukasz, Biernat, Vincent T, Grattan, Mark S, Hixon, Zachary, Prensky, Andrew R, Vaino

Publikováno v: Psychopharmacology. 239(9)

LB-102 is an N-methylated analogue of amisulpride under development to treat schizophrenia. LB-102 was evaluated in a Phase 1, double-blind, placebo-controlled, clinical study to evaluate safety and pharmacokinetics. This was a first-in-human study e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ce1bbeb9fa60f7e4371147de1793b79
https://pubmed.ncbi.nlm.nih.gov/35841422

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Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5‑HT7

Autor: Zachary Prensky, Andrew R. Vaino, Vincent T. Grattan, Mark S. Hixon

Publikováno v: ACS Omega, Vol 4, Iss 9, Pp 14151-14154 (2019)
ACS Omega

Benzamide antipsychotics such as amisulpride are dosed as racemates though efficacy is assumed to be mediated through S enantiomer binding to D2 receptors. At prescribed doses, the benzamides likely display polypharmacy since brain exposure should be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18ee55cecf568325adfa01d19153672
https://doaj.org/article/60aaa2900e364064a33e7ab458891010

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