Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes.

Autor: Dani A C Heesterbeek, Remy M Muts, Vincent P van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W Bardoel, Nina M van Sorge, Suzan H M Rooijakkers

Publikováno v: PLoS Pathogens, Vol 17, Iss 1, p e1009227 (2021)

Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope. However, many of these proteins do n

Externí odkaz: https://doaj.org/article/3864237fc065485abe33d9b2af2ec38f

Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant Staphylococcus aureus to Human Group IIA-Secreted Phospholipase A2 and Daptomycin

Autor: Marieke M, Kuijk, Yongzheng, Wu, Vincent P, van Hensbergen, Gizem, Shanlitourk, Christine, Payré, Gérard, Lambeau, Sandra, Man-Bovenkerk, Jennifer, Herrmann, Rolf, Müller, Jos A G, van Strijp, Yvonne, Pannekoek, Lhousseine, Touqui, Nina M, van Sorge

Publikováno v: Journal of Innate Immunity
Journal of Innate Immunity, 2023, 15, pp.333-350. ⟨10.1159/000527549⟩
Journal of innate immunity, 1-18. S. Karger AG
STARTPAGE=1;ENDPAGE=18;ISSN=1662-811X;TITLE=Journal of innate immunity

International audience; Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high demand for new therapeutics to treat infections. Human group IIA-secreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::25d6486a6addadcbccb6c136f4857a2b
https://hal.science/hal-03888202/file/527549.pdf

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Autor: Kevin S. McIver, Nina M. van Sorge, Andrew G. Turner, Jeffrey S. Rush, Alistair G. McEwan, Alessandro Ruda, Rebecca J. Edgar, Andrew J. Morris, Natalia Korotkova, Yoann Le Breton, Ashton T. Belew, Najib M. El-Sayed, Pan Deng, Gérard Lambeau, Konstantin V. Korotkov, Mark J. Walker, Vincent P. van Hensbergen, Göran Widmalm

Publikováno v: Nature chemical biology
Nature Chemical Biology, 15(5), 463. Nature Publishing Group
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (5), pp.463-471. ⟨10.1038/s41589-019-0251-4⟩

Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. These structures have also gained interest as vaccine antigens, in particular for the human pathogens Group AStreptococcus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc7e36f7c2a17f8f4d550242378b91f
http://europepmc.org/articles/PMC6470023

Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model

Autor: Michael J. Redd, Herman P. Spaink, Esther Schutz, Emi Murayama, Philip M. Elks, Annemarie H. Meijer, Michiel van der Vaart, Vincent P. van Hensbergen

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100928 (2014)
PLoS ONE
PLoS ONE, 9(6), e100928

Pulmonary tuberculosis (TB), caused by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb), is a major world health problem. The production of reactive nitrogen species (RNS) is a potent cytostatic and cytotoxic defense mechanism ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ee7fdf13517359ff34a9cea9e2e172
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24967596/?tool=EBI

Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

Autor: Xue-Kun Guo, Jiali Wang, Vincent P. van Hensbergen, Jintao Liu, Huji Xu, Xiaoyu Hu

Publikováno v: Cell Reports, Vol 42, Iss 7, Pp 112754- (2023)

Summary: As highly organized consortia of bacteria, biofilms have long been implicated in aggravating inflammation. However, our understanding regarding in vivo host-biofilm interactions in the complex tissue environments remains limited. Here, we sh

Externí odkaz: https://doaj.org/article/e131c9fad5244b2fab25899892ebdf55